Can ACIPAYAM, Sadık KAYA, Özlem SANGÜN, Gül İLHAN, Canan ALTUNAY, Gönül OKTAY

Hepatit A Enfeksiyonunda İmmün Trombositopenik Purpura

Gelişmemiş ülkelerde, yetersiz aşılama, kötü hijyen ve yaşam koşulları nedeniyle hepatit A yaygındır. Sekonder immun trombositopeni, Hepatit B ve C enfeksiyonlarında sık görülürken, akut hepatit A enfeksiyonu bulgusu olarak nadiren bildirilmiştir. Sekonder immun trombositopenik purpurası olan akut hepatit A enfeksiyonlu 2 olgu burada sunulmuştur.

Anahtar Kelimeler:

Hepatit A, immun trombositopenik purpura, intravenöz immunglobulin

Autoimmune Thrombocytopenic Purpura in Hepatitis A Infection

In undeveloped countries, Hepatitis A is common and endemic because of unimmunization, unhygienic nutrition and poor living conditions. Secondary immune thrombocytopenia is frequently seen in hepatitis B and C infections. It is rarely reported with acute hepatitis A. Two cases of autoimmune thrombocytopenic purpura with acute hepatitis A is presented here.

Keywords:

Hepatitis A, autoimmune thrombocytopenic purpura, intravenous immunoglobulin,

PDF

___

Nainan OV, Xia G, Vaughan G, Margolis HS. Diagnosis of hepatitis a virus infection: a molecular approach. Clin Microbiol Rev. 2006;19:63-79.
Jeong SH, Lee HS. Hepatitis A: clinical manifestations and management. Intervirology. 2010;53:15-9.
Schiff ER. Atypical clinical manifestations of hepatitis A. Vaccine. 1992;10:18-20.
Cohen O, Mevorach D, Ackerman Z, Oren R. Thrombocytopenic purpura as a manifestation of acute hepatitis A. J Clin Gastroenterol. 1993;17:166
Ertem D, Acar Y, Pehlivanoglu E. Autoimmune complications associated with hepatitis A virus infection in children. Pediatr Infect Dis J. 2001;20:809-11.
Koff RS. Clinical manifestations and diagnosis of hepatitis A virus infection. Vaccine. 1992;10:15-7.
Lemon SM. Type A viral hepatitis: epidemiology, diagnosis, and prevention. Clin Chem. 1997;43:1494
Willner IR, Uhl MD, Howard SC, Williams EQ, Riely CA, Waters B. Serious hepatitis A: an analysis of patients hospitalized during an urban epidemic in the United States. Ann Intern Med. 1998;128:111-4.
Maiga MY, Oberti F, Rifflet H, Ifrah N, Calès P. Hematologic manifestations related to hepatitis A virus. 3 cases. Gastroenterol Clin Biol. 1997;21:327
Shenoy R, Nair S, Kamath N. Thrombocytopenia in hepatitis A--an atypical presentation. Journal of tropical pediatrics. 2004;50:241-2.
Tanir G, Aydemir C, Tuygun N, Kaya O, Yarali N. Immune thrombocytopenic purpura as sole manifestation in a case of acute hepatitis A. Turk J Gastroenterol. 2005;16:217-9.
Samanta T, Das AK, Ganguly S. Profile of hepatitis A infection with atypical manifestations in children. Indian J Gastroenterol. 2010;29:31-3.
Yazışma Adresi / Address for Correspondence: Dr. Can Acıpayam Hatay Antakya State Hospital, Department of Pediatric Hematology and Oncology 31040 Hatay, Turkey. Tel: 90 326 219 40 00 Fax: +90 326 227 24 40
Email : cacipayam@hotmail.com G eliş tarihi/Received on: 26.12.2013
Kabul tarihi/Accepted on:29.01.2014