Nigar Dirican, Ceyda Anar, Şule Atalay, Önder Öztürk, H.Ahmet Bircan, Münire Çakır, Ahmet Akkaya

Hematolojik parametrelerin küçük hücreli akciğer kanserli hastalarda prognoz üzerine etkileri

Amaç: Nötrofil / lenfosit oranı (NLO) ve trombosit / lenfosit oranı (PLO) kanserin birçok türü için prognostik faktördür. Bu çalışmada, standart tedavi verilen küçük hücreli akciğer kanserli (KHAK) hastalarda prognoz ile NLR ve PLR arasındaki ilişki değerlendirilmiştir.Gereç ve Yöntem: Süleyman Demirel Üniversitesi Göğüs Hastalıkları ve Dr. Suat Seren Göğüs Hastalıkları ve Göğüs Cerrahisin’ de KHAK tanısı alan ve standart kemoterapi verilen hastalar retrospektif olarak değerlendirildi.Bulgular: Toplam 136 hasta değerlendirildi. Hastaların tanı anındaki klinik özellikleri ve hematolojik verileri toplandı. KHAK’li hastalarda tek değişkenli analiz ile cinsiyet, hastalık evresi, metastaz alan sayısı, Karnofsky performans skalası (KPS), evresine göre tedavi alması iyi prognostik faktör olarak gösterildi. Dahası, KHAK’ de tek değişkenli analiz, düşük lenfosit sayısı (<1590) ve yüksek nötrofil lenfosit oranının (≥3.7) kötü prognozu predikte ettiğini gösterdi. Yüksek NLO grubunda ortanca genel sağkalım (OS) daha kötüydü. Çok değişkenli analizde, NLR, metastaz alan sayısı, KPS, tedavi alması genel sağkalım için bağımsız prognostik faktörler olarak bulundu. Buna karşılık tanı sırasında PLO ile genel sağkalım arasında ilişki saptanmadı.Sonuç: Bu çalışma NLO’ nın, tedavi öncesi KHAK hastalarında kötü prognozun tahmin edilmesine yardımcı olabileceğini göstermiştir. Bu bulguları doğrulamak için büyük prospektif çalışmalar gerekmektedir.

Anahtar Kelimeler:

küçük hücreli akciğer kanseri, nötrofil/lenfosit oranı, prognoz

Effects on prognosis of hematologic parameters in patients with small cell lung cancer

Purpose: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are prognostic factors for various types of cancer. In this study, we assessed the association of NLR and PLR with the prognosis of small-cell lung cancer (SCLC) in patients who received the standard treatment.Material and Methods: We retrospectively reviewed patients who were diagnosed with SCLC and treated with the standard chemotherapy at Suleyman Demirel University Chest Diseases and Dr. Suat Seren Chest Diseases and Thoracic Surgery. Results: In total, 136 patients were evaluated. Patients’ clinic characteristics and hematologic tests data at initial diagnosis were collected. The univariate analysis of all SCLC patients indicated that favorable prognostic factors were gender, disease stage, the number of metastatic sites, good performance status and received treatment according to the stage. Moreover, univariate analysis showed that low lymphocyte count (<1590) and high neutrophil-lymphocyte ratio (≥3.7) predicted poor prognosis in SCLC. Median overall survival (OS) was worse in the high-NLR group. In the multivariate analysis, NLR, stage, the number of metastatic sites, karnofsky performance status (KPS), received treatment were independent prognostic factors for OS. Conclusion: This study demonstrated that the NLR could help to predict poor prognosis in SCLC patients before treatment. Larger prospective studies are required to confirm these findings.

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