Genç yetişkinlerde elektrofizyolojik ve hemodinamik parametreler üzerine kafeinli içeceklerin akut etkileri

Amaç: Kafeinli içeceklerin tüketimi son yıllarda gençler arasında önemli ölçüde artmıştır. Çalışmanın amacı, kafeinli içeceklerin genç erişkinlerin elektrokardiyografik ve hemodinamik parametreleri üzerindeki akut etkilerini araştırmaktır. Gereç ve Yöntem: Çalışma, randomize olmayan, plasebo kontrollü olmayan, üç kollu paralel bir atama olarak tasarlanmıştır. Aydın Adnan Menderes Üniversitesi'ne kayıtlı öğrenci havuzundan seçilen 56 kişi üzerinde gerçekleştirilmiştir. Başvuru kabul anketi sonuçlarına göre enerji içeceği, kahve, kola ve kontrol grupları belirlendi. Kan basıncı ve elektrokardiyogram, içecekleri tüketmeden önce ve 30 dakika ve 60 dakika sonra ölçüldü. Kalp hızı değişkenliği elektrokardiyogram sinyalinden tespit edildi ve lineer analiz ile araştırıldı. Bulgular: Tüm kafeinli içecekler kan basıncını yükseltti. Sadece enerji içeceği ve kola kalp atış hızını artırdı. Kahve grubunun ardışık R-R aralıkları arasındaki farkların karekökü ve 50 milisaniyeyi aşan NN intervallerinin sayısı (NN50) değerlerinde küçük bir artış oldu. Kahve ve kola grupları için yüksek frekans (HF) değerleri biraz arttı. Ancak düşük frekans (LF) ve LF/HF değerleri de azalmıştır. Bu değişiklikler kahve grubu için istatistiksel olarak anlamlıydı. PR intervali ve QRS kompleksi değişmedi, ancak enerji içeceği ve kola gruplarında QTc intervali QTc intervali daha düşüktü. Sonuç: Kafeinli içecek tüketimi, genç yetişkinlerin kardiyovasküler sistemi üzerinde olumsuz etkilere neden olma potansiyeline sahiptir. Kahve, enerji içeceği ve koladan daha etkin görünmektedir.

Acute effects of caffeinated beverages on electrocardiographic and hemodynamic parameters in young adults

Purpose: The consumption of caffeinated beverages has significantly increased among young people in recent years. The objective of the study is to investigate the acute effects of caffeinated beverages on electrocardiographic and hemodynamic parameters of young adults. Materials and Methods: Study was designed as a non-randomized, non-placebo controlled, three-arm parallel assignment. It was conducted on 56 individuals selected from a pool of students enrolled at Aydın Adnan Menderes University. Energy drink, coffee, cola and control groups were determined according to the results of the applicant acceptance questionnaire. Blood pressure and electrocardiogram were measured before and after consuming the drinks at 30 minutes and 60 minutes. Heart rate variability was detected from electrocardiogram signal and investigated by linear analysis. Results: All caffeinated drinks increased the blood pressure. Only, heart rate was increased by energy drink and cola. There was a small increment in root-mean square differences of successive R-R intervals and the number of times successive heartbeat intervals exceed 50ms (NN50) values in coffee group. High frequency (HF) values were increased some for coffee and cola groups. But, low frequency (LF) and LF/HF values were decreased. These alterations were statistically significant for coffee group. PR interval and QRS complex did not alter, however, QTc interval was lower in energy drink and cola groups. Conclusion: Caffeinated beverage consumption has the potential to induce adverse effects on cardiovascular system of young adults. Coffee appears to be more prominent than energy drink and cola.

___

  • 1. Olas B, Bryś M. Effects of coffee, energy drinks and their components on hemostasis: The hypothetical mechanisms of their action. Food Chem Toxicol. 2019;127:31-41.
  • 2. Temple JL, Bernard C, Lipshultz SE, Czachor JD, Westphal JA, Mestre MA. The safety of ingested caffeine: A comprehensive review. Front Psychiatry. 2017;8:80.
  • 3. James JE, Baldursdottir B, Johannsdottir KR, Valdimarsdottir HB, Sigfusdottir ID. Adolescent habitual caffeine consumption and hemodynamic reactivity during rest, psychosocial stress, and recovery. J Psychosom Res. 2018;110:16-23.
  • 4. Institute of Medicine (US) Committee on Military Nutrition Research. Caffeine for the sustainment of mental task performance: formulations for military operations. Washington (DC): National Academies Press (US); 2001. PMID: 25057583.
  • 5. Prickaerts J. Phosphodiesterase inhibitors. In: Stolerman I.P. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. 2010.
  • 6. Umemura T, Ueda K, Nishioka K, Hidaka T, Takemoto H, Nakamura S et al. Effects of acute administration of caffeine on vascular function. Am J Cardiol. 2006;98:1538-41.
  • 7. Fletcher EA, Lacey CS, Aaron M, Kolasa M, Occiano A, Shah SA. Randomized controlled trial of high- volume energy drink versus caffeine consumption on ECG and hemodynamic parameters. J Am Heart Assoc. 2017;6:e004448.
  • 8. Elitok A, Öz F, Panc C, Sarıkaya R, Sezikli S, Pala Y et al. Acute effects of Red Bull energy drink on ventricular repolarization in healthy young volunteers: a prospective study. Anatol J Cardio. 2015;15:919-22.
  • 9. Hara A, Ohide H, Miyagawa K, Takeuchi T, Nakatani Y, Yokoyama H et al. Acute effects of caffeine on blood pressure and heart rate in habitual and non- habitual coffee consumers: A randomized, double blind, placebo-controlled study. Jpn J Pharm Health Care Sci. 2014;40:383-88.
  • 10. Voskoboinik A, Koh Y, Kistler PM. Cardiovascular effects of caffeinated beverages. Trends Cardiovasc Med. 2019;29:345-350.
  • 11. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Eur Heart J. 1996;17:354–81.
  • 12. Rezuş C, Dan Moga V, Ouatu A, Floria M. QT interval variations and mortality risk: Is there any relationship? Anatol J Cardiol. 2015;15:255-8.
  • 13. Pan J, Thompkins WJ. A real-time QRS detection algorithm. IEEE Trans Biomed Eng. 1985;32:230-36.
  • 14. Acharya UR, Faust O, Sree V, Swapna G, Martis RJ, Kadri NA et al. Linear and nonlinear analysis of normal and cad-affected heart rate signals. Comput Methods Programs Biomed. 2014;113:55-68.
  • 15. Guessous I, Eap CB, Bochud M. Blood pressure in relation to coffee and caffeine consumption. Curr Hypertens Rep. 2014;16:468.
  • 16. Doerner JM, Kuetting DL, Luetkens JA, Naehle CP, Dabir D, Homsi R et al. Caffeine and taurine containing energy drink increases left ventricular contractility in healthy volunteers. Int J Cardiovasc Imaging. 2015;31:595-601.
  • 17. Mattioli AV, Pennella S, Farinetti A, Manenti A. Energy drinks and atrial fibrillation in young adults. Clin Nutr. 2018;37:1073-4.
  • 18. Zuchinali P, Ribeiro PA, Pimentel M, da Rosa PR, Zimerman LI, Rohde LE. Effect of caffeine on ventricular arrhythmia: a systematic review and meta- analysis of experimental and clinical studies. Europace. 2016;18:257-66.
  • 19. Shah SA, Szeto AH, Farewell R, Shek A, Fan D, Quach KN et al. Impact of High volume energy drink consumption on electrocardiographic and blood pressure parameters: A randomized trial. J Am Heart Assoc. 2019;8:e011318.
  • 20. Romualdo GR, Rocha AB, Vinken M, Cogliati B, Moreno FS, Chaves MAG et al. Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis. Food Res Int. 2019;123:567-89.
  • 21. Monda M, Viggiano A, Vicidomini C, Viggiano A, Iannaccone T, Tafuri D et al. Espresso coffee increases parasympathetic activity in young, healthy people. Nutr Neurosci. 2009;12:43-8.
  • 22. Teng CL, Lim WY, Chua CZ, Teo RS, Lin KT, Yeo JC. Does a single cup of caffeinated drink significantly increase blood pressure in young adults? A randomized controlled trial. Aust Fam Physician. 2016;45:65-8.
  • 23. Hajsadeghi S, Mohammadpour F, Manteghi MJ, Kordshakeri K, Tokazebani M, Rahmani E et al. Effects of energy drinks on blood pressure, heart rate, and electrocardiographic parameters: An experimental study on healthy young adults. Anatol J Cardiol. 2016;16:94-9.
  • 24. Papakonstantinou E, Kechribari I, Sotirakoglou Κ, Tarantilis P, Gourdomichali T, Michas G et al. Acute effects of coffee consumption on self-reported gastrointestinal symptoms, blood pressure and stress indices in healthy individuals. Nutr J. 2016;15:26.
  • 25. Passmore AP, Kondowe GB, Johnston GD. Renal and cardiovascular effects of caffeine: a dose-response study. Clin Sci (Lond). 1987;72:749-56.
  • 26. Ammar R, Song JC, Kluger J, White CM. Evaluation of electrocardiographic and hemodynamic effects of caffeine with acute dosing in healthy volunteers. Pharmacotherapy. 2001;21:437-42.
  • 27. Caliskan SG, Bilgin MD. Non-linear analysis of heart rate variability for evaluating the acute effects of caffeinated beverages in young adults. Cardiol Young. 2020;30:1018-23.
  • 28. Schaffer SW, Jong CJ, Ramila KC, Azuma J. Physiological roles of taurine in heart and muscle. J Biomed Sci. 2010;17:2.
  • 29. Charrière N, Loonam C, Montani JP, Dulloo AG, Grasser EK. Cardiovascular responses to sugary drinks in humans: galactose presents milder cardiac effects than glucose or fructose. Eur J Nutr. 2017;56:2105-13.
  • 30. Ali F, Rehman H, Babayan Z, Stapleton D, Joshi DD. Energy drinks and their adverse health effects: A systematic review of the current evidence. Postgrad Med. 2015;127:308-22.
  • 31. Haller CA, Jacob P, Benowitz NL. Short-term metabolic and hemodynamic effects of ephedra and guarana combinations. Clin Pharmacol Ther. 2005;77:560-71.
  • 32. Song J, Sharman T. Yohimbine induced type II myocardial injury: An underrecognized and dangerous adverse effect. Am J Med Case Rep. 2019;7:271-273.
  • 33. Ballard SL, Wellborn-Kim JJ, Clauson KA. Effects of commercial energy drink consumption on athletic performance and body composition. Phys Sportsmed. 2010;38:107-17.
  • 34. Clauson KA, Shields KM, McQueen CE, Persad N. Safety issues associated with commercially available energy drinks. J Am Pharm Assoc. 2008;48:e55-63.
  • 35. An SM, Park JS, Kim SH. Effect of energy drink dose on exercise capacity, heart rate recovery and heart rate variability after high-intensity exercise. J Exerc Nutrition Biochem. 2014;18:31-9.
  • 36. Polanczyk CA, Rohde LE, Moraes RS, Ferlin EL, Leite C, Ribeiro JP. Sympathetic nervous system representation in time and frequency domain indices of heart rate variability. Eur J Appl Physiol Occup Physiol. 1998;79:69-73.
  • 37. Shaffer F, Ginsberg JP. An overview of heart rate variability metrics and norms. Front Public Health. 2017;5:258.
  • 38. Yeragani VK, Krishnan S, Engels HJ, Gretebeck R. Effects of caffeine on linear and nonlinear measures of heart rate variability before and after exercise. Depress Anxiety. 2005;21:130-4.
  • 39. Wiklund U, Karlsson M, Oström M, Messner T. Influence of energy drinks and alcohol on post- exercise heart rate recovery and heart rate variability. Clin Physiol Funct Imaging. 2009;29:74-80.
  • 40. Nelson MT, Biltz GR, Dengel DR. Cardiovascular and ride time-to-exhaustion effects of an energy drink. J Int Soc Sports Nutr. 2014;11:2.
  • 41. El Agaty SM, Seif AA. Cardiovascular effects of long- term caffeine administration in aged rats. Ir J Med Sci. 2015;184:265-72.
  • 42. García A, Romero C, Arroyave C, Giraldo F, Sánchez L, Sánchez J. Acute effects of energy drinks in medical students. Eur J Nutr. 2017;56:2081-91.
  • 43. Ellermann C, Hakenes T, Wolfes J, Wegner FK, Willy K, Leitz P et al. Cardiovascular risk of energy drinks: Caffeine and taurine facilitate ventricular arrhythmias in a sensitive whole-heart model. J Cardiovasc Electrophysiol. 2022 Mar 18.
  • 44. Shah SA, Occiano A, Nguyen TA, Chan A, Sky JC, Bhattacharyya M et al. Electrocardiographic and blood pressure effects of energy drinks and panax ginseng in healthy volunteers: A randomized clinical trial. Int J Cardiol. 2016;218:318-23.
  • 45. Zhang Y, Post WS, Dalal D, Blasco-Colmenares E, Tomaselli GF, Guallar E. Coffee, alcohol, smoking, physical activity and QT interval duration: results from the third national health and nutrition examination survey. PLoS One. 2011;6:e17584.
Cukurova Medical Journal-Cover
  • ISSN: 2602-3032
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1976
  • Yayıncı: Çukurova Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

Böbrek nakli yapılan hastalarda nakil öncesi ve nakil sonrası enfeksiyon etkenlerinin sıklığı

Suzan DİNKÇİ, Filiz KİBAR, Erkan DEMİR, Saime PAYDAŞ, Şeyda ERDOĞAN, Akgün YAMAN

CYP2C9 gen polimorfizmlerinin losartan kullanan hipertansif hastalarda tedavi yanıtı üzerine etkisi

Funda PEPEDİL TANRIKULU, Melih O. BABAOĞLU, Banu ÇAKIR, Atilla BOZKURT, Gülay Sain GÜVEN

Epilepsili bireylerde duygu düzenleme güçlükleri ve sosyal destek: depresyon düzeyi ile ilişkisi

Bengü ALTUNAN, Aysun ÜNAL

İnfraklaviküler ve interskalen bloğun önkol oksijenasyonuna etkisi: randomize kontrollü bir çalışma

Bengü Gülhan AYDIN, Dilek OKYAY, Gamze KÜÇÜKOSMAN, Hilal AYOĞLU, Eren AÇIKGÖZ, Özcan PİŞKİN

Aşil tendonu gerinim oranı ile mitral anulus kalsifikasyonu varlığı arasındaki ilişki

Burçak ÇAKIR PEKÖZ, Arafat YILDIRIM

İletişim bozukluğu tanılı çocuklarda duygusal davranışsal sorunlar, ebeveyn tutum özellikleri, ebeveyn stres düzeyi ve ilişkili faktörlerin sağlıklı kontrollerle karşılaştırılması

Barış GÜLLER, Ferhat YAYLACI

Depo antipsikotik kullanan hastalarda prolaktin düzeyi, cinsel fonksiyon, vücut kitle indeksi ve karaciğer fonksiyon testlerinin karşılaştırılması

Gülay TAŞÇI, Filiz ÖZSOY

COVID-19 pnömonisi öntanısı alan ağır solunum yetmezliği ile sonuçlanan sağ atriyal psödoanevrizma olgusu

Veysel TOSUN

Kuduz aşısı uygulamasına bağlı omuz yaralanması: bir olgu sunumu

Hatice KAPLANOĞLU, Veysel KAPLANOĞLU, Aynur TURAN, Ece ÜNLÜ AKYÜZ

Gossypin’in prostat kanser hücrelerinde MMP-2 ve MMP-9 genleri üzerindeki etkisinin araştırılması

Ebubekir DİRİCAN, İrfan ÇINAR