Arafat YILDIRIM, Ozge OZCAN ABACIOGLU, Mehmet Cenk BELİBAĞLI

Covid-19 enfeksiyonunda objektif nutrisyonel indekslerin hastane içi mortaliteye etkisi

Amaç: Koronavirüs hastalığı 2019 (COVID-19) tanısı nedeniyle yoğun bakım ünitelerinde yatan hastaların beslenme durumunun hastane içi mortaliteye etkisi belirsizdir. Çalışma, COVID-19 enfeksiyonu hastalarında iki objektif nutrisyonel indeksler olan controlling nutritional status score (CONUT) ve prognostic nutritional indeksi (PNI) nin hastane içi mortalite ilişkisini analiz etmeyi amaçladı. Gereç ve Yöntem: Çalışmaya 11 Mart-10 Mayıs 2020 tarihleri arasında yoğun bakım ünitelerinde yatan 187 COVID-19 hastası dahil edildi. Demografik ve klinik verileri kaydedildi. CONUT ve PNI skorları laboratuvar sonuçlarından hesaplandı. Hastalar mortalite grup ve ve non-mortalite grup olmak üzere iki gruba ayrıldı. Bulgular: Hastaların ortalama yaşı 66.2±15.8 yıl (% 55,3 erkek), ölüm oranı % 20,8 (n = 39) idi. Mortalite grubunda Medyan PNI skorları anlamlı olarak daha düşük ve medyan CONUT skorları anlamlı olarak daha yüksek belirlendi. Çok değişkenli regresyon analizinde, PNI ve CONUT un mortalite ile bağımsız olarak ilişkili olduğunu belirlendi. Ayrıca ROC eğrisi analizlerinde, CONUT un hastane içi mortaliteyi tahmin etmede, PNI'den daha iyi bir performansa sahip olduğunu belirlendi. Sonuç: COVID-19 hastalarında, CONUT ve PNI skorlarının hastane içi mortalitede bağımsız prediktörler olduğunu ve CONUT'un PNI'dan daha iyi bir performansa sahip olduğu belirlenmiştir.

The impact of objective nutritional indexes on in-hospital mortality in Covid-19 infection

Purpose: The effect of nutritional status on in-hospital mortality in patients with coronavirus disease 2019 (COVID-19) is unclear. We aimed to analyze the relationship between nutritional status score (CONUT) and prognostic nutritional index (PNI) and in-hospital mortality in COVID-19 infection. Materials and Methods: We included 187 patients with COVID-19 between 11 March-10 May 2020. The CONUT and PNI scores were calculated using the laboratory results. The groups were divided into survival and in-hospital mortality Results: The mean age of the patients was 66.2±15.8 years (55.3% male). The mortality rate was 20.8% (n=39). The median PNI scores was significantly lower and the median CONUT score was significantly higher in the mortality group. Multivariate regression analysis showed that PNI and CONUT were independent predictors of mortality. ROC curve analyses showed that CONUT had a better performance than PNI to predict in-hospital mortality. Conclusion: In COVID-19 patients, CONUT and PNI scores were independently associated with in-hospital mortality, with CONUT presenting a better performance than PNI.

Keywords:

coronavirus disease 2019, CONUT, PNI,

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