Sema BAYKARA, Şahin KARAKAŞ, Şuheda KAYA, Gülay TAŞCI, Selda TELO

Borderline kişilik bozukluğunda dürtüsellik ve saldırganlık ile kan ghrelin, D vitamini, lipit düzeyleri arasındaki ilişki

Amaç: Bu çalışmada Borderline Kişilik Bozukluğu (BKB)’da impulsivite ve agresyonun serum ghrelin, lipit ve D vitamini düzeyleriyle ilişkisinin araştırırılması planlandı. Gereç ve Yöntem: Çalışmaya BKB tanılı 30 kadın hasta ve 30 sağlıklı kontrol dâhil edildi. Katılımcılara Sosyodemografik ve Klinik Bilgi Formu, Beck Anksiyete Envanteri, Beck Depresyon Envanteri, Barratt Dürtüsellik Ölçeği-Kısa Form (BIS-11-KF), Buss-Perry Saldırganlık Ölçeği (BPSÖ) uygulandı. Bulgular: Ghrelin, kolesterol ve trigliserit seviyeleri BKB hastalarında daha yüksekti, D Vitamini, HDL ve LDL açısından anlamlı farklılık yoktu. Ghrelin ile lipitler ve D vitamini arasında ilişki tespit edilmedi. BIS-11 ve BPSÖ puanlarında, gruplar arasında anlamlı farklılık vardı. Ghrelin ile BIS-11 puanları arasında pozitif bir ilişki bulundu. D vitamini ile BPSÖ alt boyutu olan ‘öfke’ puanı arasında pozitif bir ilişki bulundu. Trigliserit ile BPSÖ alt boyutu olan ‘sözel saldırganlık’ puanı arasında negatif bir ilişki bulundu. Sonuç: BKB, hastane başvurularının çok olduğu, komorbid durumların sık eşlik ettiği, sosyal ilişkileri ve işlevselliği bozan ve tedavisi güç olan bir bozukluktur. Ghrelin regülasyonu, Vitamin D ve lipit düzeylerinin düzenlenmesi hastalığın tedavisinde ve klinik takibinde klinisyenlere fayda sağlayabilir

Anahtar Kelimeler:

Borderline kişilik bozukluğu, impulsif davranış, agresyon, ghrelin, vitamin D, lipitler

Relationship between impulsivity, aggression and blood ghrelin, vitamin D, lipids levels in borderline personality disorder

Purpose: This study aimed to investigate the correlations between impulsivity and aggression, and blood ghrelin, lipids, and vitamin D levels in Borderline Personality Disorder (BPD). Materials and Methods: Thirty female patients with BPD and 30 healthy controls were included to the study. Sociodemographic Data Form, Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Barratt Impulsivity Scale Short Form (BIS-11-SF), Buss-Perry Aggression Questionnaire (BPAQ) were applied. Results: Ghrelin, cholesterol, and triglyceride (TG) levels were higher in BPD patients (p=0.013, p=0.042, p=0.019, respectively); however, there was no significant difference between the groups based on vitamin D, High-density lipoprotein (HDL) and Low-density lipoprotein (LDL) levels. There was no correlation between ghrelin, and lipid and vitamin D levels. The BIS-11 and BPAQ scores were higher in BPD group. A positive correlation was determined between ghrelin and BIS-11 scores. A positive correlation was found between vitamin D and ‘anger’ subscale score of BPAQ. A negative correlation was identified between triglyceride and the ‘verbal aggression’ subscale score of BPAQ. Conclusion: BPD is a disorder with several hospital admissions, frequent comorbid conditions, problematic social relationships, and functionality, and the treatment is quite difficult. Regulation of Ghrelin, vitamin D and lipid levels could assist clinicians in the treatment and clinical follow-up of the disease.

Keywords:

Borderline personality disorder;, impulsive behavior;, ; aggression, ghreline, vitamin d, lipids,

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