Ayşen Türedi YILDIRIM, Yeşim OYMAK, Yöntem YAMAN, Osman SAATÇİ, Rana MALATYALI, Serra KAMER, Hüdaver ALPER

Akut Lenfoblastik Lösemide İzole Optik Sinir Relapsı: İki Olgu Sunumu

Lösemili hastalarda yoğun kemoterapi, intratekal metotrexate tedavileri ve proflaktik santral sinir sistemi radyoterapisine rağmen ekstramedüller relapslar görülebilmektedir. Akut lenfoblastik lösemili hastalarda izole optik sinir relapsı nadir görülür ve kemik iliği tutulumu gelişmeden önce ani görme kaybı ile belirti verebilir. Erken tanı ve hızlı tedavi ile görüş kaybı tamamen düzeltilebilir. Burada izole optik sinir tutulumu ile relaps olan ve ani görme kaybı ile başvuran 10 ve 12 yaşlarında, pre-T akut lenfoblastik lösemili, iki erkek hasta literatür bilgileri eşliğinde tartışıldı.

Anahtar Kelimeler:

Optik sinir relapsı, pre T akut lenfoblastik lösemi, Ani görme kaybı.

Isolated Optic Nerve Relapse in Acute Lymphoblastic Leukemia: Two Case Reports

Notwithstanding extensive chemotherapy, intrathecal methotrexate treatments and prophylactic central nervous system radiotherapy, extramedullary relapses can still be seen in leukemia patients. Isolated optic nerve relapses, one of its symptoms being a sudden vision loss that occurs prior to a bone marrow relapse, are rarely seen in acute lymphoblastic leukemia patients. Sudden vision loss can be cured by an early diagnosis and rapid treatment. In this study, we investigate two male patients (10 and 12 years old) with optic nerve relapses, sudden vision loss complaints and pre-T acute lymphoblastic leukemia in the light of the literature.

Keywords:

Optic nerve relapse, pre-T acute lymphoblastic leukemia, Sudden vision loss,

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Yazışma Adresi / Address for Correspondence: Dr. Ayşen Türedi Yıldırım Celal Bayar Üniversitesi Tıp Fakültesi Hastanesi Çocuk Hematoloji Kliniği Uncubozköy Y erleşkesi MAN İSA E-mail: aysen_turedi@hotmail.com G eliş tarihi/Received on :24.03.2014

Kabul tarihi/Accepted on: 02.05.2014