Sinem BERİK SAFÇİ, Leyla YILMAZ, Ramazan MEMİŞOĞLU, Özlem ADMIŞ, Şengül CANGÜR, Ali ANNAKKAYA, Peri ARBAK, Ege GÜLEÇ BALBAY, Betül ARI

Serum Asimetrik Dimetil Arjinin (ADMA) Düzeyi ve Obstruktif Uyku Apne Sendromu (OUAS) Ağırlığı Arasındaki İlişki

Giriş: Obstrüktif Uyku Apne Sendromu (OUAS) olan hastalarda ortaya çıkan tekrarlayan hipoksemi ve reoksijenasyon oksidatif stres mekanizmalarını tetikleyebilir. Oksidatif stres OUAS hastalarında Asimetrik dimetilarginin (ADMA) düzeylerini artırır. Amaç: Serum Asimetrik Dimetil Arjinin (ADMA) düzeyi ve ObstrÜktif Uyku Apne Sendromu (OUAS) ağırlığı arasındaki ilişkiyi incelemeyi amaçladık. Method: Polisomnografi yapılan 330 hasta kayıtları retrospektif olarak değerlendirildi. Anormal serum glukozu, lipid, tiroid, böbrek ve karaciğer bozuklukları olan hastalar çalışma dışı bırakıldı. Kabul kriterleri 72 sağladı. Hastalar apne hipopne indekslerine göre beş gruba ayrıldılar. Asimetrik Dimetil Arjinin ölçümleri ELİSA kiti ile yapıldı. Bulgular: Ortalama yaş 44,19 ± 14,24 idi. Hastaların %31,9'u kadındı . Hastalar normal, ağır, orta, hafif, rem-pozisyonel olarak gruplandığında; %26, %25, %6,9 , %16,7 ve %25 oranlarındaydılar. AHI ve ADMA arasında anlamlı korelasyon saptandı (r= 0,483; p10) ve negatif olabilirlik oranı (LR-) 0,28 (LR-

Anahtar Kelimeler:

obstrüktif uyku apne sendromu, hipoksemi, ADMA

Relationship Between Serum Asymmetric Dimethylarginine (ADMA) Level And Obstructive Sleep Apnea Syndrome (OSAS) Severity

Introduction: The repetitive hypoxemia can induce oxidative stress mechanisms. Oxidative stress increases serum ADMA levels in patients with OSAS. Aim: To investigate the relationship between serum levels of ADMA and OSAS severity. Methods: 330 patient’s records, who underwent overnight polysomnography (PSG) were retrospectively examined. The patients who had a abnormal serum glucose, lipid, thyroid, renal and liver function tests levels, had excluded. 72 patients had participating criteria. Patients were categorized into five groups according to apnea/hipopnea index (AHI). Measurement of ADMA levels was performed by ELISA kit. Results: The mean age was 44,19 ± 14,24 years. 31,9 % of the patients were female. Patients in normal group, severe, medium, mild and positional–REM dependent OSAS group were 26,4%, 25%, 6,9 %, 16,7% and 25%; respectively. A significant positive correlation was found between AHI and ADMA (r= 0,483; p 10) and the negative likelihood ratio was (LR-) 0,28 (R-

Keywords:

obstructive sleep apnea, hypoxemia, ADMA,

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