Sinan USLU, Fatih BOLAT, Ali BÜLBÜL, Demet DEMİRKOL, Fatima MOUSTAFA, Çetin VURAL

Doğumsal Dev Boyun Lenfanjiomunda Bleomisin Tedavisinin Etkinliği: Vaka Sunumu

Lenfanjiom yenidoğan döneminde baş ve boyun bölgesinin en sık görülen konjenital kistik malformasyonlarındandır. Nörovasküler yapıların infiltre olduğu durumda eksizyonu zor ve nüks oranı oldukça yüksektir. Bu durumda en yaygın olan alternatif tedavi yöntemi intralezyonel sklerozan madde enjeksiyonudur. Bu makalede yenidoğan döneminde cerrahi eksizyon sonrası nüks eden konjenital dev boyun lenfanjiomunda, tek doz intralezyonel bleomisin uygulama- sının etkinliği literatür bilgileri eşliğinde tartışıldı

Anahtar Kelimeler:

Yenidoğan, lenfanjiom, bleomisin

Effectiveness of Bleomycin Therapy for Congenital Giant Cervical Lymphangioma: A Case Report

Lymphangioma is one of the most common congenital cystic malformation of the head and neck region in the neonatal period. In situations where neurovascular struc- tures are infiltrated, the excision of the lesion is difficult and recurrence rate is high. In that case, the most common alternative treatment is intralesional injection of sclerosing agents. In this case report, the effectiveness of a single dose intralesional bleomycin for therapy of the congenital cervi- cal lymphangioma which recurred after surgical excision has been discussed together with the relevant literature

Keywords:

Newborn, lymphangioma, bleomycin,

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1. Stringel G. Hemangiomas and lymphangiomas. In: Aschraft KWH, ed. Pediatric Surgery. Phidelphia: 1990: 802-22.
2. Bhattacharyya NC, Yadav K, Mitra SK, Pathak IC. Lymphangiomas in children. Aust N Z J Surg 1981;51(3):296- 300. http://dx.doi.org/10.1111/j.1445-2197.1981.tb05961.x
3. Bill AH, Jr. Sumner DS. A Unified concept of lymphangioma and cystic hygroma. Surg Gynecol Obstet 1965;120:79-86. PMid:14259790
4. Yoo JC, Ahn Y, Lim YS, Hah JH, Kwon TK, Sung MW, et al. OK-432 sclerotherapy in head and neck lymphangiomas: long-term follow-up result. Otolaryngol Head Neck Surg 2009;140(1):120-3. http://dx.doi.org/10.1016/j.otohns.2008.10.026 PMid:19130974
5. Sanlialp I, Karnak I, Tanyel FC, Senocak ME, Büyükpamukçu N. Sclerotherapy for lymphangioma in children. Int J Pediatr Otorhinolaryngol 2003;67(7):795-800. http://dx.doi.org/10.1016/S0165-5876(03)00123-X
6. Ameh EA, Nmadu PT. Cervical cystic hygroma: pre-, intra-, and post-operative morbidity and mortality in Zaria, Nigeria. Pediatr Surg Int 2001;17(5-6):342-3. http://dx.doi.org/10.1007/s003830000558 PMid:11527161
7. Sung MW, Lee DW, Kim DY, Lee SJ, Hwang CH, Park SW, et al. Sclerotherapy with picibanil (OK-432) for congenital lymphatic malformation in the head and neck. Laryngoscope 2001;111(8):1430-3. http://dx.doi.org/10.1097/00005537-200108000-00020 PMid:11568580
8. Mikovic Z, Simic R, Egic A, Opincal TS, Koprivsek K, Stanojevic D, et al. Intrauterine treatment of large fetal neck lymphangioma with OK-432. Fetal Diagn Ther 2009;26(2): 102-6. http://dx.doi.org/10.1159/000238111 PMid:19752516
9. Adejuyigbe O, Abubakar AM, Sowande OA, Olayinka OS, Uba AF. Experience with anorectal malformations in Ile-Ife, Nigeria. Pediatr Surg Int 2004;20(11-12):855-8. http://dx.doi.org/10.1007/s00383-004-1297-1 PMid:15565306
10. Okada A, Kubota A, Fukuzawa M, Imura K, Kamata S. Injection of bleomycin as a primary therapy of cystic lymphangioma. J Pediatr Surg 1992;27(4):440-3. http://dx.doi.org/10.1016/0022-3468(92)90331-Z
11. Orford J, Barker A, Thonell S, King P, Murphy J. Bleomycin therapy for cystic hygroma. J Pediatr Surg 1995;30(9):1282-7. http://dx.doi.org/10.1016/0022-3468(95)90485-9