Aysegul GULBAHAR, Gaye ÇAKAL, PH.D., Sevim DİNÇER CENGİZ, Gamze Sinem ÇAĞLAR

The Dietary, Serum and Urine Analysis of Boron and Micronutrients in Postmenopausal Women

Objective: Boron is a nutritionally important trace element that interacts with other micronutrients. Boron plays a critical role in bone mineralization and metabolism. In the present study, the association between boron and micronutrients related to bone metabolism was analysed in postmenopausal women. Methods: In a prospective cohort study in 40 postmenopausal women 24-hour urine and blood samples were collected for sodium, phosphorus, calcium, magnesium, and boron. Daily food consumption, bone mineral density, and Fracture risk assessment tool scores were recorded. Results: The mean age was 53.2 ± 5.9 years. Dietary habits revealed insufficient dietary fiber and excessive dietary sodium. The serum and urine boron levels were 26.80 μg/L and 21.22 μg/day, respectively. Urine boron levels were lower in the osteoporosis group (p = 0.66). A negative correlation between urine Na and boron was detected (p

Keywords:

Boron, Mineral Metabolism, Menopause, Bone,

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Nielsen FH. Evidence for the nutritional essentiality of boron. J Trace Elem Exp Med. 1996; 9:215–229.
Nielsen FH, Gallagher SK, Johnson LK, Nielsen EJ. Boron enhances and mimics some effects of estrogen therapy in postmenopausal women. J Trace Elem Exp Med. 1992; 5:237-246.
Nielsen FH, Penland JG. Boron supplementation of perimenopausal women affects boron metabolism and indices associated with macromineral metabolism, hormonal status and immune function. J Trace Elem Exp Med. 1999; 12:251–261.
Hunt CD. The biochemical effects of physiologic amounts of dietary boron in animal nutrition models. Environ Health Perspect. 1994; 102(7): 35-43.
Nielsen FH. Update on human health effects of boron. J Trace Elem Med Biol. 2014; 28: 383-387.
Devirian TA, Volpe SL. The physiological effects of dietary boron. Crit Rev Food Sci Nutr. 2003; 43: 219-231.
Palacios C. The role of nutrients in bone health, from A to Z. Crit Rev Food Sci Nutr. 2006; 46:621-628.
Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med. 1999; 130(6):461-470.
World Health Organization. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis Geneva. WHO Technical Report Series No. 843; 1994.
Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster JY, Borgstrom F, Rizzolli R et al. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2008; 19:399-428.
World Health Organization. WHO Scientific group on the assessment of osteoporosis at primary health care level. Summary Meeting Report, Brussels, Belgium, 1-13; 2004.
Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. Washington (DC): The National Academies Press; 2011.
Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington (DC): National Academies Press; 1997.
Institute of Medicine. Dietary reference intake for water, potassium, sodium, chloride, and sulfate., Washington (DC): The National Academies Press; 2005.
Goulle J-P, Mahieu L., Casterman J, Neveu N, Bonneau L, Laine G, Bouige D, Lacroix C. Metal and metalloid multi-elementary ICP-MS validation in whole blood, plasma, urine and hair reference values. Forensic Science Int. 2005; 153:39-44.
Macdonald HM, Black AJ, Aucott L, Duthie G, Duthie S, Sandison R, Hardcastle AC, New SAL, Fraser WD, Reis DM. Effect of potassium citrate supplementation or increased fruit and vegetable intake on bone metabolism in healthy postmenopausal women: a randomized controlled trial. Am J Clin Nutr. 2008; 88(2):465-474.
Mobasheri A, Golding S, Pagakis SN, Corkey K, Pocock AE, Fermor B, O’Brien MJ, Wilkins RJ, Ellory JC, Francis MJ. Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts. Cell Biol Int. 1998; 22(7-8):551-562.
Alvarez-Lefmans FJ, Giraldez F, Gamino SM. Intracellular free magnesium in excitable cells: Its measurement and its biologic significance. J Physiol Pharmacol. 1987; 65:915-925.
Park Y, Kwon SJ, Ha YC. Association between urinary sodium excretion and bone health in male and female adults. Ann Nutr Metab. 2016; 68(3):189-196.
Kwon SJ, Ha YC, Park Y. High dietary sodium intake is associated with low bone mass in postmenopausal women: Korea National Health and Nutrition Examination Survey, 2008-2011. Osteoporos Int. 2017; 28(4):1445-1452.
Peacock M. Phosphate metabolism in health and disease. Calcif Tissue Int. 2021; 108(1):3-15.
Reinhart RA. Magnesium metabolism: A review with a special reference to the relationship between intracellular content and serum levels. Arch Intern Med. 1988; 148:2415-20.