Şebnem ERÇALIK YALÇINKAYA

166

Oral prekanseröz lezyonlarda doku otofloresansı esaslı ışıkla değerlendirme yöntemi: Derleme

Amaç: Oral mukozanın otofloresans özellikleri oral prekanseröz lezyonların erken tanısında artan bir ilgiyle karşılanmaktadır. Son dönemde ışık esaslı oral kanser görüntülemeye yardımcı cihazlar ağız muayenesi ve tanıyı desteklemek amacıyla geliştirilmektedir. Bu cihazlar özel olarak tasarlanmış ışık kaynağıyla ağız muayenesinde mukozayı belirginleştirmek için otofloresans özelliğini kullanmaktadırlar. Bu bildirinin amacı ışık esaslı bir otofloresan izleme yönteminin oral premalign ve malign lezyonlarda potansiyel fayda ve risklerini ortaya koymaktır. Yöntem: Geniş literatür araştırması ve bu sistemlerden biriyle klinik tecrübe sistem değerlendirmesine olanak sağlamıştır. Bulgular: Bu yazıda prekanseröz ve kanserli lezyonların belirlenmesinde yardımcı izleme yöntemlerinden bir tanesi değerlendirilmiştir. Sistemin özellikleri ve dezavantajları değerlendirilmiş, klinisyenin dikkatine sunulmuştur. Sonuç: Günümüzdeki yenilikler malignite potansiyeli olan lezyonların erken tanısında yararlı olabilmektedir, ancak bunların tek başına diagnostik araçlar olmadığı, daha çok yardımcı araçlar oldukları düşünülerek dikkatle kullanılmaları gerekmektedir. Otofloresan kaybı mukozada displaziyi belirlemekte rol oynamakla beraber bu lezyonlar klinik bilgi ve deneyimle değerlendirilmelidir.
Anahtar Kelimeler:

Otofloresans, velscope, prekanseröz lezyon

A light based screening method based on tissue autofluorescence for oral precancerous lesions: a review

Objective: Autofluorescence properties of oral mucosa has been gaining interest in the field of early diagnosis of oral precancerous lesions. To aid the oral cancer screening, light based systems have recently been developed in order to assist the oral examination and identification. These systems feature light sources with certain wavelength designed according to principles of tissue reflectance and autofluorescence to enhance the conventional oral examination. The purpose of this report is to address the potential benefits and potential risks of a light based autofluorescence screening method for potentially premalignant and malignant lesions. Methods: Extensive literature review and personal clinical experience with one of these technologies enabled the evaluation of the system. Results: This manuscript evaluated the use of one of the adjunctive screening methods to detect precancerous and cancerous lesions. The characteristics of the system were outlined, the limitations associated with autofluorescence screening were put forward for the clinician’s conderation. Conclusion: Recent technologies in the early detection of potentially malignant lesions may be beneficial, however they should be used with cautious since they are only adjunctive methods. Loss of autofluorescence seems to play a role for identifying mucosal dysplasia but lesions should be evaluated with clinical knowledge and experience.
Keywords:

Autofluorescence, velscope, precancerous lesion,

PDF

___

  • Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer. 2001; 94: 15-16.
  • Jermal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60: 277-300.
  • Day GL, Blot WJ. Second primary tumors in patients with oral cancer. Cancer. 1992; 70: 14-19.
  • Lingen MW, Kalmar JR, Karrison T, Speight PM. Critical evaluation of diagnostic aids for the detection of oral cancer. Oral Oncol. 2008; 44: 10Napier SS, Speight PM. Natural history of potentially malignant oral lesions and conditions: an overview of the literature. J Oral Pathol Med. 2008; 37: 1-10.
  • Rethman MP, Carpenter W, Cohen EE, Epstein J, Evans CA, Flaitz CM, Graham FJ et al. Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas. American Dental Association Council on Scientific Affairs Expert Panel on Screening for Oral Squamous Cell Carcinomas. J Am Dent Assoc. 2010; 141: 509-520.
  • Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007; 36: 575-580.
  • Lingen MW. Screening for Oral Premalignancy and Cancer: What Platform and Which Biomarkers? Cancer Prev Re.s 2010; 3: 1056-1059.
  • Jayaprakash V, Sullivan M, Merzianu M, Rigual NR, Loree TR, Popat SR et al. Autofluorescence-guided surveillance for oral cancer. Cancer Prev Res (Phila). 2009; 2: 966-974.
  • Warnakulasuriya KA, Johnson NW. Sensitivity and specificity of OraScan(R) toluidine blue mouthrinse in the detection of oral cancer and precancer. J Oral Pathol Med. 1996; 25: 97-103.
  • Remmerbach TW, Weidenbach H, Hemprich A, Böcking A. Earliest detection of oral cancer using non-invasive brush biopsy including DNA-image-cytometry: report on four cases. Anal Cell Pathol. 2003; 25: 159-166.
  • Maraki D, Becker J, Boecking A. Cytologic and DNA-cytometric very early diagnosis of oral cancer. J Oral Pathol Med. 2004; 33: 398-404.
  • Schwarz F, Maraki D, Yalcinkaya S, Bieling K, Böcking A, Becker J. Cytologic and DNA-cytometric follow-up of oral leukoplakia after CO2- and Er: YAG-laser assisted ablation: a pilot study. Lasers Surg Med. 2005; 37: 29-36.
  • Maraki D, Yalcinkaya S, Pomjanski N, Megahed M, Boecking A, Becker J. Cytologic and DNA-cytometric examination of oral lesions in lichen planus. J Oral Pathol Med. 2006; 35: 227-232.
  • Pektas ZO, Keskin A, Günhan O, Karslioğlu Y. Evaluation of nuclear morphometry and DNA ploidy status for detection of malignant and premalignant oral lesions: quantitative cytologic assessment and review of methods for cytomorphometric measurements. J Oral Maxillofac Surg. 2006; 64: 628-635.
  • Navone R, Burlo P, Pich A, Pentenero M, Broccoletti R, Marsico A, Gandolfo S. The impact of liquid-based oral cytology on the diagnosis of oral squamous dysplasia and carcinoma. Cytopathology. 2007; 18: 356-3
  • Epstein JB, Silverman S Jr, Epstein JD, Lonky SA, Bride MA. Analysis of oral lesion biopsies identified and evaluated by visual examination, chemiluminescence and toluidine blue. Oral Oncol. 2008; 44: 538-544.
  • Bouquot JE, Suarez P, Vigneswaran N. Oral precancer and early cancer detection in the dental office. Review of new technologies. J Implant Advanced Clin Dent. 2010; 2: 47-63.
  • Kerr AR, Sirois DA, Epstein JB. Clinical evaluation of chemiluminescent lighting: an adjunct for oral mucosal examinations. J Clin Dent. 2006; 17: 59-63.
  • Betz CS, Mehlmann M, Rick K, Stepp H, Grevers G, Baumgartner R, et al. Autofluorescence imaging and spectroscopy of normal and malignant mucosa in patients with head and neck cancer. Lasers Surg Med. 1999; 25: 323-334.
  • Velscope. “http://www.velscope.com/default.aspx?id=0&cat= professionals” Accessed February 23, 2013.
  • Svistun E, Alizadeh-Naderi R, El-Naggar A, Jacob R, Gillenwater A, Richards-Kortum R. Vision enhancement system for detection of oral cavity neoplasia based on autofluorescence. Head Neck. 2004; 26: 205-2
  • Pavlova I, Williams M, El-Naggar A, Richards-Kortum R, Gillenwater A. Understanding the biological basis of autofluorescence imaging for oral cancer detection: high-resolution fluorescence microscopy in viable tissue. Clin Cancer Res. 2008; 14: 2396-2404.
  • Roblyer D, Kurachi C, Stepanek V, Williams MD, El-Naggar AK, Lee JJ, et al. Objective detection and delineation of oral neoplasia using autofluorescence imaging. Cancer Prev Res (Phila). 2009; 2: 423-431.
  • Lane PM, Gilhuly T, Whitehead P, Zeng H, Poh CF, Ng S, et al. Simple device for the direct visualization of oral-cavity tissue fluorescence. J Biomed Opt. 2006; 11: 024006.
  • Poh CF, Zhang L, Anderson DW, Durham JS, Williams PM, Priddy RW, et al. Fluorescence visualization detection of field alterations in tumor margins of oral cancer patients. Clin Cancer Res. 2006; 12: 6716-6722.
  • Poh CF, Ng SP, Williams PM, Zhang L, Laronde DM, Lane P, et al. Direct fluorescence visualization of clinically occult high-risk oral premalignant disease using a simple hand-held device. Head Neck. 2007; 29: 71-76. de Veld DC, Skurichina M, Witjes MJ, Duin RP, Sterenborg DJ, Star WM, et al. Autofluorescence characteristics of healthy oral mucosa at different anatomical sites. Lasers Surg Med. 2003; 32: 367-376.
  • Farah CS, McIntosh L, Georgiou A, McCullough MJ. Efficacy of tissue autofluorescence imaging (VELScope) in the visualization of oral mucosal lesions. Head Neck. 2012; 34: 856-862.
  • Scheer M, Neugebauer J, Derman A, Fuss J, Drebber U, Zoeller JE. Autofluorescence imaging of potentially malignant mucosa lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011; 111: 568-577. Wilder-Smith P, Holtzman J, Epstein J, Le A. Optical diagnostics in the oral cavity: an overview. Oral Dis. 2010; 16: 717-728.
  • Balevi B. Assessing the usefulness of three adjunctive diagnostic devices for oral cancer screening: a probabilistic approach. Community Dent Oral Epidemiol. 2011; 39: 171-176.
  • Awan KH, Morgan PR, Warnakulasuriya S. Evaluation of an autofluorescence based imaging system (VELscopeTM) in the detection of oral potentially malignant disorders and benign keratoses. Oral Oncol. 2011; 47: 274-277.
  • Rana M, Zapf A, Kuehle M, Gellrich NC, Eckardt AM. Clinical evaluation of an autofluorescence diagnostic device for oral cancer detection: a prospective randomized diagnostic study. Eur J Cancer Prev. 2012; 21: 460-466.
  • McNamara KK, Martin BD, Evans EW, Kalmar JR. The role of direct visual fluorescent examination (VELscope) in routine screening for potentially malignant oral mucosal lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012; 114: 636-643.
  • Yalcinkaya S, Dumlu A, Özbayrak S. Oral mukozada direkt floresans ışığı ile prekanserözlerin tanısı yapılabilir mi? TDB Derg. 2009; 113: 68Wu JY, Yi C, Chung HR, Wang DJ, Chang WC, Lee SY, et al. Potential biomarkers in saliva for oral squamous cell carcinoma. Oral Oncol. 2010; 46: 226-231.
  • Hooper SJ, Wilson MJ, Crean SJ. Exploring the link between microorganisms and oral cancer: a systematic review of the literature. Head Neck. 2009; 31: 1228-1239.
  • Emekli-Alturfan E, Demir G, Kasikci E, Tunali-Akbay T, Pisiriciler R, Caliskan E, Yarat A. Altered biochemical parameters in the saliva of patients with breast cancer. Tohoku J Exp Med. 2008; 214: 89-96.
Clinical and Experimental Health Sciences-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2011
  • Yayıncı: Marmara Üniversitesi
Arşiv
Sayıdaki Diğer Makaleler

Özel hastane acil bakım kliniklerinde elektronik hekim orderlarının etkinliği ve çıktıları

Gonca MUMCU, Leyla KÖKSAL, Nur ŞİŞMAN, Ramazan Özgür ÇATAR

Periodontal kemikiçi defektlerin rejeneratif tedavisinde trombositten zenginleştirilmiş fibrin membran ve otojen kemik grefti kullanımının klinik ve radyolojik olarak değerlendirilmesi. Olgu serisi

Taner ARABACI, Alper KIZILDAĞ, Oğuz KÖSE

Ayaktan indekse transplantasyon sonrası fizyoterapi programı: Olgu sunumu

Zeynep TUNA, Deran OSKAY, Serhan TUNCER

Fonksiyonel endoskopik sinüs cerrahisinde multidetektör bilgisayarlı tomografide paranasal sinüslerin anatomik varyasyonları

Filiz NAMDAR PEKİNER

Oral prekanseröz lezyonlarda doku otofloresansı esaslı ışıkla değerlendirme yöntemi: Derleme

Şebnem ERÇALIK YALÇINKAYA