Kannabinoid tip 1 reseptör (CB1) ve terapötik yaklaşımlara genel bakış-II

Kannabinoid tip 1 (CB1) reseptörleri merkezi sinir sistemi ve periferik organlardaki düzenleyici rollerinden dolayı pek çok hastalığın patofizyolojisinde önemli rol oynarlar. Kannabinoidlerin psikotrop etkileri nedeniyle kullanımları kısıtlandığından endokannabinoidleri metabolize eden enzimlerin (FAAH, MAGL) inhibisyonuyla endokannabinoidlerin arttırılması daha avantajlı bir tedavi stratejisi olabilir. Ayrıca kan-beyin engelini geçmeyen antagonistler ve agonistler de periferik CB1 reseptörlerini hedefleyerek terapötik amaçlı kullanılabilirler. Genel olarak CB1 reseptör aktivasyonu ağrı, anksiyete, depresyon, travma sonrası stres bozukluğu, postmenopozal osteoporoz, kanser ve nörodejeneratif hastalıkların tedavisinde, inhibisyonu ise obezite, diyabet, karaciğer hastalıkları, kardiyometabolik komplikasyonlar, alkol ve ilaç bağımlılığı ve postmenopozal osteoporoz tedavisinde terapötik amaçlı kullanılabilirler. Derlememizin bu kısmında kannabinoid reseptörlerin tedavi potansiyelleri özetlenmiştir.

An overview of cannabinoid receptor 1 (CB1) and therapeutic approaches-II

Cannabinoid receptor 1 (CB1) is highly important in the pathophysiology of several diseases due to their regulatory roles in central nervous system and peripheral tissues. Direct use of cannabinoids is limited mostly because of their psychoactive properties; therefore augmenting endocannabinoids by inhibiting the enzymes responsible for their degradation (e.g. FAAH, MAGL) appears as a valuable therapeutic strategy. Furthermore, peripherally restricted CB1 agonists and antagonists emerge as novel therapeutics. While activation of CB1 receptors can be used for the treatment of pain, anxiety, depression, PTSD, post-menopausal osteoporosis, cancer and neurodegenerative disorders; inhibition of this system can be used for the treatment of obesity, diabetes, liver and cardiometabolic disorders, post-menopausal osteoporosis and addiction. Here we summarized the therapeutical considerations for the cannabinoid system.
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