Gulgun BOSGELMEZ-TİNAZ

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Bakteriyel iletişimin sisteminin (Quorum Sensing) kesilmesi: Bakteri aracılı hastalıklarla savaşta umut vaat eden yeni bir yol

Antibiyotikler bakteriyel enfeksiyonların tedavisinde yaygın bir şekilde kullanılmaktadırlar. İlaç tedavisinde antibiyotiklerin gereksiz ve rastgele kullanımları, bu ajanlara karşı yaygın direnç gelişmesine neden olmuştur. Çoklu antibiyotik direncine sahip bakterilerin ortaya çıkması ve hızla yayılması, halihazırda mevcut antibiyotiklerle bakteriyel infeksiyonların tedavisini giderek güçleştirmektedir. Dolayısıyla, bakterilerle savaş yeteneğimizin azaldığı post-antibiyotik bir dönemle karşı karşıyayız ve infeksiyöz hastalıklarla başa çıkmak için yeni stratejilere olan gereksinim gün geçtikçe artmaktadır. Patojenik bakterilerin patojenite ve virülans faktörlerinin üretimini bakteriler arası iletişim sistemini kullanarak düzenlendiklerinin keşfi, bakteriler arası iletişim sistemini antimikrobiyal tedavi için cazip bir hedef haline getirmiştir. Bakterileri öldürmek yerine patogenezi hedef almak, direnç gelişimi için daha az seçici baskı uygulayabilir, bu nedenle bakteriyel iletişim inhibitörleri kullanarak bakteriler arası iletişimin inaktive edilmesi, infeksiyöz hastalıkların tedavisi için büyük umut vaat etmektedir.
Anahtar Kelimeler:

Hücreler arası iletişim, antibiyotik direnci, quorum sensing inhibitörleri

Disruption of bacterial cell-to-cell communication (Quorum Sensing): a promising novel way to combat bacteria-mediated diseases

Antibiotics are commonly used for the treatment of bacterial infections. The inappropriate and indiscriminate application of antibiotics in pharmacotherapy has led to the development of widespread resistance to these agents. With the emergence and spread of multi antibiotic-resistant bacteria, it is becoming increasingly more difficult to treat bacterial infections with currently available antibiotics. Thus, we are facing a post-antibiotic era with a reduced capability to fight bacteria, and, hence, there is an increasing need for new strategies to cope with infectious diseases. The discovery that many pathogenic bacteria employ quorum sensing (QS) to regulate their pathogenicity and virulence factor production makes the QS system an attractive target for antimicrobial therapy. Targeting the pathogenesis instead of killing the organism may provide less selective pressure for the development of resistance. Therefore, it has been suggested that inactivating the QS system in bacteria by the use of QS inhibitors holds great promise for the treatment of infectious diseases.
Keywords:

Cell-to-cell communication, antibiotic resistance, quorum sensing inhibitors,

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Clinical and Experimental Health Sciences-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2011
  • Yayıncı: Marmara Üniversitesi
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