Background and Design.- This is a retrospective evaluation of 252 patients with gastric carcinoma (151 males and 101 females) followed up in the Department of Oncology, Cerrahpaşa Faculty of Medicine. Effects of five different chemotherapy pro¬tocols on survival are compared on an adjuvant and metastatic basis. Results.- 8.3% of the patients were in stage II, while 31.7% were in stage III, and 60% were stage IV. Histologically 57% of the tumors were low differ¬entiated adenocarcinoma. 36.5% of the patients were found to have inoperable disease at the time of their admission. There was a positive correlation between the initial CEA and CA 19-9 levels and the stage of the disease. In the metastatic group, the mean follow-up period was 219 days (median: 183), while in the adjuvant group it was 441.85 days (median: 359). The CDDP+FU+FA protocol given in an adjuvant basis, was shown to induce a survival period of 42 months. This was statistically significant when compared to other protocols (p