Duodenal divertikülosis olgularında klinik analiz ve literatürün gözden geçirilmesi

İlerleyen yaş ile daha sıklıkla karşılaşılırsa da duodenal divertikülozis nadir bir klinik antitedir. Üst Gastrointestinal muayenelerde rastlantısal olarak keşfedilen duodenal divertiküller ekseriyetle asemptomatiktir, ancak önemli morbidite kaynağı olabilir. Duodenal divertikül majör duodenal papillanın yakınına yerleşmişse juxtapapiller (periampuller) duodenal divertikül olarak isimlendirilirler. Bu çalışmanın hedefi duodenal divertiküllü hastalarda klinik karakteristikler sıklık klinik bulgular ve tedavi çeşitlemelerini araştırmaktır. Biz 1983-2003 arasında kliniğimizde cerrahi tedavi geçirmiş duodenal divertikül olgularının retrospektif olarak gözden geçirdik. Klinik bulgular ve patolojik sonuçları olguların kayıtlarından öğrenilmiştir. 1983'ten 2003 kadar duodenal divertiküllü 25 hasta kliniğimizde tedavi edildi. Onların yaşları 43-80 yaşları arasında değişiyordu. Ortalama yaşları 58,1 idi. Olguların 15'i kadın (%60) 10'nu erkek idi (%40). Duodenum 2. bölümünde divertiküller 15 (% 60) olguda tespit edildi Duodenum 3. bölümünde divertiküller 6 olguda (%24) ve 4. bölümünde 4 olguda (%16) tespit edildi. Multipl divertiküller sadece 2 olguda bulundu. 9 olguda nüks kolanjit atakları ilerleyici sarılık batın ağrısını kapsayan bilio-pankreatik semptomlar vardı. 3. ve 4. bölümlerin divertiküllü hastalarında batın ağrısı ve kusma ana semptomlardır. Divertikülektomi etkili bir cerrahi işlemdir. Juxtapapiller duodenal divertiküller bilier taş oluşmasında önemli sebep olucu faktörlerdir. Gastrointestinal kanalda, divertikül hastalığının kolon'dan sonra ikinci en sık yerleşim yeri duodenum'dur. Hastalığın klinik olarak önemi, sadece akademik olarak ilginç oluşundan, hastaların hayatını tehdit eden komplikasyonlara kadar değişir. Kolon dışında nadir olması sebebiyle, ekseriya hastaların şikayetlerinin bir duodenal divertikül (DD) kaynaklı olduğu düşünülmeyebilir. Bu da teşhiste gecikmeye yol açar.1,2 Bu retrospektif çalışmada kliniğimizde DD sebebiyle cerrahi tedavi görmüş hastalar irdelenmiştir.

Clinical analysis and review of related literature in cases of duodenal diverticulosis

Background and Design.- Duodenal diverticular disease is an uncommon clinical entity; however, with progressive aging of the population, duodenal diverticulosis is encountered more often. Duodenal diverticula, discovered incidentally in patients during upper gastrointestinal examinations, are usually asymptomatic, but can be the source of significant morbidity. When duodenal divertucula are located near the major duodenal papilla, they are called juxtapapillary (periampullary) duodenal diverticula. The aim of this study was to investigate the frequency, clinical characteristics, findings and possible varieties of treatment of duodenal diverticula in patients with duodenal diverticula. We retrospectively reviewed the cases of duodenal diverticulum undergone surgical treatment between 1983 and 2003. Clinical findings and pathological results were learned from records of cases. Results.- 25 patients with duodenal diverticula were treated at our clinic from 1983 to 2003. Their age was comprised between 43 and 80 years. Mean age of them was 58.1 years. Fifteen of cases were women (60%) while ten were men (40%). The second part of duodenum was involved in 15 cases (60%). The third part of duodenum was involved in 6 cases (24%) and the fourth in 4 cases (16%) Multiple diverticula were found only 2 cases. 9 patients had bilio-pancreatic symptoms including in recurrent episodes of cholangitis, progressive jaundice and abdominal pain. In patients with diverticula of third and fourth part, abdominal pain and vomiting were the main symptoms.Conclusions.- Diverticulectomy is an effective surgical procedure. Juxtapapillary duodenal diverticula are important causative factors in the formation of biliary stones.

___

  • 1. Brian JE, Stair JM. Noncolonic Diverticular Disease, Surg. Gynecol Obstetr, 1985; 161: 189-94.
  • 2. Umbricht – Sprunali R, Hollinger A, Meier L, Largiader F. Die komplikationen von Divertikeln in Oberen Bündarm, Chirurg: 1992; 63: 568-71.
  • 3. Gross SA, Katz S. Small Bowel Diverticulosis: An Overlooked Entity. Curr Treat Options Gastroenterol 2003; 6: 3-10.
  • 4. Kouraklis G, et al. Diverticular Disease of the Small Bowel: Report of 27 Cases. Int Surg. 2001; 86: 235-401.
  • 5. Whang EE, Ashley SW, Zinner MJ. In Small Intestine; Brunicardi FC, Anderson DK, Billiar TR. Dunn DL Hunter JG, Pollock RE (Eds); Schwart’s Principles of Surgery; 8th Ed. Mc Graw-Hill Medical Publishing Division; 2005; 1017-54.
  • 6. Lapin R, Kamath ML, Engler J, Friedman H. Massive Gastrointestinal Hemorrhage from a Duodenal Diverticulum, Am.J Gastroenterol 1974; 610: 185-90.
  • 7. Tocchi A, Basso L, Gosta G, Lepre L, Liotta G, Mazzom G. Surgical Treatment of Duodenal Diverticula Acta Chir Belg. 1993; 93: 145-146.
  • 8. Afridi SA, Fichtenbaum CJ, Taubin H. Review of Duodenal Diverticula Am J Gastroenterol 1991; 86: 935-38.
  • 9. Osnes M, Lotveit T, Larsen S, Aune S. Duodenal Diverticula and Their Relation to Age Sex and Biliary Calculi Scand J Gastroenterol 1981; 16: 103-112.
  • 10. Lobo DN, Balfour TW, Iftikhar SY. Periampullary Diverticula and Pancreaticabiliary Disease Br J. Surg: 1999; 86: 588-593.
  • 11. Pinatti HW, Tacla M, Conte VP, Bettavello A. Diverticulos Duodenais Juxta-Ampulares Arg Gastroenter 1966; 3: 209-215.
  • 12. Leivonen MK, Halttunen JA, Kivilaakso EO. Duodenal Diverticulum at Endoscopic Retrograde Cholangiopancreato-Graphy; Analysis of 123 patients Hepatogastroenterology; 1996; 43; 961-66.
  • 13. Yin WY, Chen HT, Huang SM, Lin HH, Chang TM. Clinical Analysis and Literature Review of Massive Duodenal Diverticular Bleeding World J Surg 2001; 25: 848-55.
  • 14. Hendelsman JC, Murphy G, Fishbein K. Duodenal Diverticulum; Clinical Significance and Surgical Treatment. Am J Surg 1960; 26: 272-77.
  • 15. Jones TW, Merendino KA. The Perplexing Duodenal Diverticulum Surgery; 1960; 481068-84.
  • 16. Zoepf T, .Zoepf DS, Arnold JC, Benz C, Riemann JC. The Relationship between Juxtapapillary Duodenal Diverticula and Disorders of the Biliopancreatic System: Analysis of 350 Patients Gastrointest Endosc 2001; 54:56-61.
  • 17. Finnie IA, Ghosh P, Garvey C, .Poston GJ, Rhodes JM. Intraluminal Duodenal Diverticulum Causing Recurrent Pancreatitis; Treatment by Endoscopy Gut: 1994; 35:557-59.
  • 18. Ketsel W, Fischbach W, Wilhelm A. Rare Cause of Acute Pancreatitis: Phytobezoar in an İntraluminal Diverticulum in Type-I Duodenal Atresia, İntestinal Malrotation and Rudimentary Pancreas Anulare Z. Gastroenterol 1998; 36: 295-9.
  • 19. Massucco P, Sabbatina F, Fornarı M. Surgical Treatment of İnternal Duodenal Diverticulum: Report of 2 Clinical Cases Minerva Chir 1999; 54: 813-17.
  • 20. Tsukamato T, Ohta Y, Hamba H, Sasaki Y, Tokuhara T, Kubo S, Hirohashi K, Kinoshita H. Perforated Duodenal Diverticulum: Report of two Cases Hepatogastroenterology; 1999; 46: 1755-58.
  • 21. Franzen D, Gurtler T, Metzger U. Solitary Duodenal Diverticulum with Enterolith as a Rare Cause of Acute Abdomen Swiss Surg 2002; 8: 277-9.
  • 22. Sakurai Y, Miura H, Matsubara T, Imazu H, Hasegawa S, Ochiai M. Perforated Duodenal Diverticulum successfully Diagnosed Preoperatively with Abdominal CT scan Associated with Upper Gastrointestinal Series J Gastroenterol 2004; 39: 379-83.
  • 23. Yokomuro S, Uchida E, Arima Y, Mizuguchi Y, Shimizu T, Kawahigashi Y, Kawamoto M, Takahashi K, Arai M, Arima Y, Tajiri T. Simple Closure of a Perforated Duodenal Diverticulum: “a Case Report” J Nippon Med Sch 2004; 71: 337-9.
  • 24. Cavanagh JE Jr. Iatrogenic Perforation of Perivaterion Duodenal Diverticulum: Report of a Case Can J Surg 1996; 39: 336-8.
  • 25. Juler GL, List JW, Stemmer EA, Connoly JE. Perforated Duodenal Diverticulitis Arch Surg 1969; 99: 572-8.
  • 26. Duarte B, Nagy KK, Cintron J. Perforated Duodenal Diverticulum Br J Surg 1992; 79; 877-81.
  • 27. Vanek VW, Mc Namara K, Lyras LS. Perforated Duodenal Diverticulum: Case Report and Literature Review Contemp Surg; 1989; 34: 36-47.
  • 28. Atmani A, Lachachi F, Sodji M, Darand-Fontanier S, Moumovni I, Pech De La Clause B, Valleix D, Des Eottes B. Perforated Juxta-Papillary Duodenal Diverticula: Two Cases Gastroenterol Clin Biol 26; 285-8.
  • 29. Patterson RH, Bromberg B. Surgical Significance of Duodenal Diverticula Ann Surg. 1951; 134: 834-40.
  • 30. Rowlands BC, King PA. Duodenal Diverticulum Perforating into Abdominal Aorta Causing Fatal Hemorrgage Br J Surg 1954; 41: 415-20.
  • 31. Coelho JC, Sousa GS, Salvalaggio PR. Laparoscopic Treatment of Duodenal Diverticulum Surg Laporose Endosc 1999; 9: 74-7.
  • 32. Tagaya N, Shimoda M, Hamada K, Ishikawa K, Kogure H. Laparoscopic Duodenal Diverticulectomy Surg Endosc 2000; 14: 592-599.
  • 33. Ryan ME, Hamilton JW, Morrissey JF. Gastrointestinal Hemorrhage from a Duodenal Diverticulum Gastrointest Endosc 1984; 30: 84-92.
  • 34. Bradham GB, Martin JB. Massive Bleeding from a Polyp in a Duodenal Diverticulum Ann Surg 1962; 156: 81-8.
  • 35. Gunsar F, Yıldız C, Aydın A, Ozutemiz OA. Angiodysplasia in a Duodenal Diverticulu as an Unusual Cause of Upper GastrointestinalBleeding Eur J Gastroenterol Hepatol 2001; 13: 717-19.
  • 36. Mahajan SK, Vaidya P, Sood BR, Gupta D, Sharma A. Duodenal Diverticular Hemorrhage in a Patient Taking NSAID J Assoc Physicians India 2003; 51: 416-8.
  • 37. Pises P. Bleeding Duodenal Diverticulum Am J Gastroenterol: 1965; 43: 121-26.
  • 38. Callery MP, Aliperti G, Soper NJ. Laparoscopic Duodenal Diverticulectomy Following Hemorrhage Surg Laparosc Endosc 1994; 4: 134-8.
  • 39. Avit-Miossec S, Alves A, Vahedi K, Paris Y, Laisne MJ, Richet F, Valleur P. Diagnostic and Therapeutic Strategy in Duodenal Diverticular Bleeding: Report of two Cases and Review of Literature Ann Chir 2004; 129: 170-3.
  • 40. Hamada N, Ishizaki N, Shirahama K, Nakamura N, Murata R, Kadono J, Shimazaki T, Sameshima T, Misono T, Taira A. Multiple Duodeno-Jejunal Diverticula Causing Massive İntestinal Bleeding J Gastroenterol 2000; 35: 159-62.
  • 41. Gunji N, Miyamoto H. Endoscopic Management of Upper Gastrointestinal Bleeding from a Duodenal. Diverticulum Hepatogastroenterology 2004; 50: 1940-42.
  • 42. Novacek G, Walgram M, Bauer P, Schofl R, Gondl A, Potzi R. The Relationship between Juxtapapillary Duodenal Diverticula and Biliary Stone Disease Eur J. Gastroenterol Hepatol 1997; 9: 375-9.
  • 43. De Koster E, Denis P, Monte M, Otero J, Nyst J, Jonas C, Van Gossum M, De Reuck M, Deltenre M. Juxtapapillary Duodenal Diverticula: Association with Biliary Stone Disease Acta Gastroenterol Belg. 1990; 53: 338-43.
  • 44. Rajnakova A, Goh PM, Ngoi SS, Lim SG. ERCP in Patients with Periampullary Diverticulum. Hepatogastroenterology; 2003; 50: 625-8.
  • 45. Uoma G, Manes G, Ragozzino A, Cavallera A, Rapitti PG. Periampullary Extraluminal Duodenal Diverticula and Acute Pancreatitis: An underestimated Etiological Association Am J Gastroenterol 1996; 91: 1186-8.
  • 46. Tham TC, Kelly M. Association of Periampullary Duodenal Diverticula with Bile Duct Stones and with Technical Success of Endoscopic Retrograde Cholangiopancreatography Endoscopy; 2004; 36: 1050-3.
  • 47. Christoforidis E, Goulimaris I, Kanellos I, Tsalis K, Dadoukis I. The Role of Juxtapapillary Duodenal Diverticula in Biliary Stone Disease Gastrointest Endosc. 2002; 55: 543-7.
  • 48. Kim MH, Myung SJ, Seo DW, Lee SK, Kim YS, Lee MH, Yoo BM. Association of Periampullary Diverticula with Primary Choledochilithiasis, but not with Secondry Choledocholithiasis Endoscopy; 1998; 30: 601-4.
  • 49. Lotveit T, Osnes M. Duodenal Diverticula Scand J Gastroenterol 1980; 19: 579-81.
  • 50. Sugiyama M, Atomi Y. Periampullary Diverticula Cause Pancreaticobiliary Reflux Scand J Gastroenterol 2001; 36: 994-7.
  • 51. Van Nieuwkoop C, Boere I, Rosekrans PA, Bac DJ. Recurrent Bacterial Cholanaitis due to a Juxtapapillary Diverticulum Eur J Gastroenterol Hepatol 2002; 14: 189-90.
  • 52. Castilho Netto JM, Speranzini MB. Ampullary Duodenal Diverticulum and Cholangitis Sao Paulo Med J. 2003; 121: 173-5.
  • 53. Chandy G, Hart WJ, Roberts-Thomson IC. An Analysis of the Relationship between Bile Duct Stones and Periampullary Duodenale Diverticula J. Gastroenterol Hepatol 1997; 12: 29-33.
  • 54. Egawa N, Kamisawa T, Tu Y, Sakaki N, Tsuru K, Okamato A. The Role of Juxtapapillary Duodenal Diverticulum in the Formation of Gallbladder Stones Hepatogastroenterology, 1998; 45: 917-20.
  • 55. Madanick RD, Barkin JS. Juxtapapillary Duodenal Diverticula and Biliopancreatic Disease Am J Gastroenterol 2002; 97: 1834-40.
  • 56. Yıldırgan MI, Basoğlu M, Yılmaz I, Atamanalp SS, Balık AA, Aydınlı B, Öztürk G. Periampullary Diverticula Causing Pancreatobiliary Disease Dig Dis Sci 2004; 49: 1943-5.
  • 57. Vassilakis JS, Tzovaras G, Chrysos E, Mouzas I, Manousos O, Xynos E, Roux-en-Y. Choledochojejunostomy and Duodenojejunostomy for the Complicated Duodenal Diverticulum Am J Surg 1997; 174: 45-8.
  • 58. Trondsnen E, Rosseland AR, Baka AO. Surgical Management of Duodenal Diverticulum Acta Chir Scand 1990; 156: 383-6.