İnsan Bağırsak Mikrobiyomu Covid-19 İçin Tedavi Stratejileriyle İlişkilendiren Mekanizmalar

Son zamanlardaki COVID-19 salgını, dünya çapında biyoloji, sosyal etkileşim ve halk sağlığının çehresini değiştirmiştir. Dünyada milyonlarca insan üzerinde yıkıcı bir etkisi ve bunun sonucunda 2020-2021 peryodunda yaklaşık 18 milyonun üzerinde ölüm vakası olduğu tahmin edilmektedir. Ülkemizde bu rakam 100000’in üzerinde olarak belirtilmiştir. Ortaya çıkan kanıtlar, enfeksiyon ile bağırsak mikrobiyom durumu arasında bir bağlantı olduğunu öne sürmektedir. Bu etki, enfeksiyonun şiddetine katkıda bulunabilecek birkaç faktörden biri olarak sayılabilmektedir. Bağırsakların bağışıklık, iltihaplanma durumu ve patojenlerle mücadele etme yeteneği ile yoğun bir şekilde bağlantılı olduğu gerçeği göz önüne alındığında, viral sonuca potansiyel olarak reddetmenin bir yolu olarak bağırsak mikrobiyotasına diyet müdahalesini düşünmek faydalı olacaktır

Anahtar Kelimeler:

Bağırsak mikrobiyomu, COVID-19, Prebiyotikler, Probiyotikler, Sinbiyotikler

Mechanisms Linking The Human Gut Microbiome To Treatment Strategies For Covid-19

The recent COVID-19 pandemic has changed the face of biology, social interaction and public health worldwide. It has had a devastating impact on millions of people around the world, with an estimated over 18 million deaths in the 2020-2021 period. In our country, this figure is over 100000. Emerging evidence has suggested a link between the infection and gut microbiome status. This is one of the many different factors that may contribute towards intensity of infection. Given the fact that the gut is heavily linked to immunity, inflammatory status and the ability to challenge pathogens, it is worthwhile to consider dietary intervention of the gut microbiota as means of potentially challenging the viral outcome. In this context, probiotics and prebiotics have been used to reduce similar respiratory infections. Here, we summarise links between the gut microbiome and COVID-19 infection, as well as propose mechanisms whereby probiotic and prebiotic interventions may act.

Keywords:

COVID-19, Gut microbiome, Probiotics, Prebiotics, Synbiotics,

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