Yeşil Çay ve Sağlık

Camellia sinensis bitkisinden farklı üretim süreçleriyle altı farklı çay çeşidi üretilmektedir. Bunlardan biri olan yeşil çay, fermantasyon basamağına uğramadığından diğer çay çeşitlerine göre daha yüksek kateşin içeriğine sahiptir. İçeriğinde bulunan önemli biyoaktif bileşenlerden biri olan Epigallokateşin gallat’ın kardiyovasküler hastalıklar, kanser, nörodejeneratif hastalıklar, cilt problemleri üzerine koruyucu etkisinin olduğu ayrıca ağırlık yönetimi ve mikrobiyota üzerine potansiyel sağlık yararının olduğunu gösteren çalışmalar mevcuttur. Yeşil çayın sağlık yararını daha iyi anlayabilmek için biyoyararlanımını artıran ve azaltan bileşenlerin varlığı ile toksik etki bildiren durumların dikkatle incelenmesi gerekmektedir. Bu derleme yeşil çaya geniş bir perspektiften bakarak yeşil çayın çeşitli sağlık yararlarını ve izlediği metabolik yolları irdelemektedir.

Anahtar Kelimeler:

Sağlık, Camellia sinensis, Yeşil çay, Kateşinler, Epigallokateşin gallat

Green Tea and Health

Six different types of tea are produced after different processes from Camellia sinensis. One of them, green tea, has a higher content of catechin than other types of tea, because it is not exposed to the fermentation step. There are studies showing that Epigallocatechin gallate, one of the important bioactive components contained in green tea, has a protective effect on cardiovascular diseases, cancer, neurodegenerative diseases, skin problems, as well as potential health benefits on weight management and microbiota. In order to better understand the health benefit of green tea, it is necessary to carefully examine the presence of components that increase and reduce bioavailability and cases that report toxic effects. The purpose of this article is to examine the various health benefits of green tea and its metabolic mechanisms.

Keywords:

Health, Camellia sinensis, Green tea, Catechins, Epigallocatechin gallat,

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Abdelkawy KS, Abdelaziz RM, Abdelmageed AM, Donia AM, El-Khodary NM. 2020. Effects of green tea extract on atorvastatin pharmacokinetics in healthy volunteers. European J Drug Metaolism and Pharmacokinet, 45(3): 351-360. DOI: 10.1007/s13318-020-00608-6.
Abe SK, Saito E, Sawada N, Tsugane S, Ito H, Lin Y, Inoue M. 2019. Green tea consumption and mortality in Japanese men and women: a pooled analysis of eight population-based cohort studies in Japan. European J Epidemiol, 34(10): 917-926. DOI: 10.1007/s10654-019-00545-y.
Alves Ferreira M, Oliveira Gomes AP, Guimarães de Moraes AP, Ferreira Stringhini ML, Mota JF, Siqueira Guedes Coelho A, Borges Botelho P. 2017. Green tea extract outperforms metformin in lipid profile and glycaemic control in overweight women: A double-blind, placebo-controlled, randomized trial. Clinical Nutri ESPEN, 22: 1-6. DOI: 10.1016/j.clnesp.2017.08.008.
Axling U, Olsson C, Xu J, Fernandez C, Larsson S, Ström K, Berger K. 2012. Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J mice. Nutri and Metab, 9(1): 105. DOI: 10.1186/1743-7075-9-105.
Barranco Quintana JL, Allam MF, Del Castillo AS, Navajas RFC. 2009. Parkinson’s disease and tea: A quantitative review. Journal of the American College of Nutri, 28(1): 1-6. DOI: 10.1080/07315724.2009.10719754.
Binnert C, Seematter G, Tappy L, Giusti V. 2003. Effect of metformin on insulin sensitivity and insulin secretion in female obese patients with normal glucose tolerance. Diabetes and Metabol, 29(2-I): 125-132. DOI: 10.1016/S1262-3636(07)70018-6.
Bokuchava MA, Skobeleva NI, Sanderson GW. 1980. The biochemistry and technology of tea manufacture. C R C Critical Rev in Food Sci and Nutri, 12(4): 303-370. DOI: 10.1080/10408398009527280.
Chen IJ, Liu CY, Chiu JP, Hsu CH. 2016. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial. Clinical Nutri, 35(3): 592-599. DOI: 10.1016/j.clnu.2015.05.003.
Chung JE, Kurisawa M, Kim YJ, Uyama H, Kobayashi S. 2004. Amplification of antioxidant activity of catechin by polycondensation with acetaldehyde. Biomacromolecules, 5(1): 113-118. DOI: 10.1021/bm0342436.
Dostal AM, Arikawa A, Espejo L, Kurzer MS. 2016. Long-term supplementation of green tea extract does not modify adiposity or bone mineral density in a randomized trial of overweight and obese postmenopausal women. j Nutri, 146(2): 256-264. DOI: 10.3945/jn.115.219238.
Dostal AM, Samavat H, Bedell S, Torkelson C, Wang R, Swenson K, Kurzer MS. 2015. The safety of green tea extract supplementation in postmenopausal women at risk for breast cancer: results of the Minnesota Green Tea Trial. Food and ChemToxicol, 83: 26-35. DOI: 10.1016/j.fct.2015.05.019.
Fang X, Azain M, Crowe-White K, Mumaw J, Grimes JA, Schmiedt C, Park HJ. 2019. Effect of acute ıngestion of green tea extract and lemon juice on oxidative stress and lipid profile in pigs fed a high-fat diet. Antioxidants, 8(6): 195. DOI: 10.3390/antiox8060195.
FAOSTAT. 2020. Metadata. URL: http://www.fao.org/faostat/en/#data/QC%0A (erişim tarihi: 10.02.2021).
Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Reid G. 2017. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Rev Gastroenterol & Hepatol, 14(8): 491-502. DOI: 10.1038/nrgastro.2017.75.
Golzarand M, Toolabi K, Aghasi M. 2018. Effect of green tea, caffeine and capsaicin supplements on the anthropometric indices: A meta-analysis of randomized clinical trials. J Functional Foods, 46: 320-328. DOI: 10.1016/j.jff.2018.04.002.
Graham HN. 1992. Green tea composition, consumption, and polyphenol chemistry. Preventive Medic, 21(3): 334-350. DOI: 10.1016/0091-7435(92)90041-F.
Gurley BJ, Miousse IR, Nookaew I, Ewing LE, Skinner CM, Jenjaroenpun P, Koturbash I. 2019. Decaffeinated reen tea extract does not elicit hepatotoxic effects and modulates the gut microbiome in lean B6C3F1 mice. Nutrients, 11(4): 776. DOI: 10.3390/nu11040776.
Hibi M, Takase H, Iwasaki M, Osaki N, Katsuragi Y. 2018. Efficacy of tea catechin-rich beverages to reduce abdominal adiposity and metabolic syndrome risks in obese and overweight subjects: A pooled analysis of 6 human trials. Nutrition Res, 55: 1-10. DOI: 10.1016/j.nutres.2018.03.012.
IARC. 2020. All cancers. URL: https://gco.iarc.fr/today (erişim tarihi: 02.02.2021).
Janssens PLHR, Hursel R, Westerterp-Plantenga MS. 2015. Long-term green tea extract supplementation does not affect fat absorption, resting energy expenditure, and body composition in adults. j Nutri, 145(5): 864-870. DOI: 10.3945/jn.114.207829.
Janssens PLHR, Penders J, Hursel R, Budding AE, Savelkoul PHM, Westerterp-Plantenga MS. 2016. Long-term green tea supplementation does not change the human gut microbiota. PLOS ONE, 11(4): e0153134. DOI: 10.1371/journal.pone.0153134.
Jiang H, Yu F, Qin L, Zhang N, Cao Q, Schwab W, Song C. 2019. Dynamic change in amino acids, catechins, alkaloids, and gallic acid in six types of tea processed from the same batch of fresh tea (Camellia sinensis L.) leaves. J Food Compos and Anal, 77: 28-38. DOI: 10.1016/j.jfca.2019.01.005.
Jin G, Yang Y, Liu K, Zhao J, Chen X, Liu H, Dong Z. 2017. Combination curcumin and (−)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway. Oncogenesis, 6(10): e384-e384. DOI: 10.1038/oncsis.2017.84.
Jin JS, Touyama M, Hisada T, Benno Y. 2012. Effects of green tea consumption on human fecal microbiota with special reference to Bifidobacterium species. Microbiol and Immunol, 56(11): 729-739. DOI: 10.1111/j.1348-0421.2012.00502.x.
Kapetanovic IM, Crowell JA, Krishnaraj R, Zakharov A, Lindeblad M, Lyubimov A. 2009. Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogs. Toxicology, 260(1–3): 28-36. DOI: 10.1016/j.tox.2009.03.007.
Kim TE, Shin KH, Park JE, Kim MG, Yun YM, Choi DH, Lee J. 2018. Effect of green tea catechins on the pharmacokinetics of digoxin in humans. Drug Design, Devel and Therapy, 12: 2139-2147. DOI: 10.2147/DDDT.S148257.
Kuriyama S, Shimazu T, Ohmori K, Kikuchi N, Nakaya N, Nishino Y, Tsuji I. 2006. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: The Ohsaki study. J American Medical Assoc, 296(10): 1255-1265. DOI: 10.1001/jama.296.10.1255.
Lam WH, Kazi A, Kuhn DJ, Chow LMC, Chan ASC, Ping Dou Q, Chan TH. 2004. A potential prodrug for a green tea polyphenol proteasome inhibitor: Evaluation of the peracetate ester of (-)-epigallocatechin gallate [(-)-EGCG]. Bioorganic and Medic Chem, 12(21): 5587-5593. DOI: 10.1016/j.bmc.2004.08.002.
Landis-Piwowar KR, Huo C, Chen D, Milacic V, Shi G, Tak HC, Dou QP. 2007. A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent. Cancer Res, 67(9): 4303-4310. DOI: 10.1158/0008-5472.CAN-06-4699.
Lee KO, Kim SN, Kim YC. 2014. Anti-wrinkle effects of water extracts of teas in hairless mouse. Toxicological Res, 30(4): 283-289. DOI: 10.5487/TR.2014.30.4.283.
Lin JK, Liang YC, Lin-Shiau SY. 1999. Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade. Biochemi Pharmacol, 58(6): 911-915. DOI: 10.1016/S0006-2952(99)00112-4.
Lv H, Zhang Y, Shi J, Lin Z. 2017. Phytochemical profiles and antioxidant activities of Chinese dark teas obtained by different processing technologies. Food Res Int, 100: 486-493. DOI: 10.1016/j.foodres.2016.10.024.
Mielgo-Ayuso J, Barrenechea L, Alcorta P, Larrarte E, Margareto J, Labayen I. 2014. Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: Randomised, double-blind, placebo-controlled clinical trial. British J Nutri, 111(7): 1263-1271. DOI: 10.1017/S0007114513003784.
Molinari M, Watt KDS, Kruszyna T, Nelson R, Walsh M, Huang WY, Peltekian K. 2006. Acute liver failure induced by green tea extracts: Case report and review of the literature. Liver Transplant, 12(12): 1892-1895. DOI: 10.1002/lt.21021.
Momose Y, Maeda-Yamamoto M, Nabetani H. 2016. Systematic review of green tea epigallocatechin gallate in reducing low-density lipoprotein cholesterol levels of humans. Int J Food Sci and Nutri, 67(6): 606-613. DOI: 10.1080/09637486.2016.1196655.
Okello EJ, Mather J. 2020. Comparative kinetics of Acetyl- and Butyryl-Cholinesterase inhibition by green tea catechins-Relevance to the symptomatic treatment of Alzheimer’s disease. Nutrients, 12(4): 1090. DOI: 10.3390/nu12041090.
Oketch-Rabah HA, Roe AL, Rider CV, Bonkovsky HL, Giancaspro GI, Navarro V, Ko R. 2020. United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts. Toxicology Rep, 7: 386-402. DOI: 10.1016/j.toxrep.2020.02.008.
Oyama J, Shiraki A, Nishikido T, Maeda T, Komoda H, Shimizu T, Node K. 2017. EGCG, a green tea catechin, attenuates the progression of heart failure induced by the heart/muscle-specific deletion of MnSOD in mice. J Cardiol, 69(2): 417-427. DOI: 10.1016/j.jjcc.2016.05.019.
Pang J, Zhang Z, Zheng T, Bassig BA, Mao C, Liu X, Peng Y. 2016. Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis. Int J Cardiol, 202: 967-974. DOI: 10.1016/j.ijcard.2014.12.176.
Platero JL, Cuerda-Ballester M, Ibáñez V, Sancho D, Lopez-Rodríguez MM, Drehmer E, de la Rubia Ortí JE. 2020. The impact of coconut oil and Eepigallocatechin gallate on the levels of IL-6, anxiety and disability in Multiple Sclerosis patients. Nutrients, 12(2): 305. DOI: 10.3390/nu12020305.
Rady I, Mohamed H, Rady M, Siddiqui IA, Mukhtar H. 2018. Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea. Egyptian J Basic and Applied Sci, 5(1): 1-23. DOI: 10.1016/j.ejbas.2017.12.001.
Rojo MÁ, Garrosa M, Jiménez P, Girbés T, Garcia-Recio V, Cordoba-Diaz M, Cordoba-Diaz D. 2020. Unexpected toxicity of green tea polyphenols in combination with the Sambucus RIL Ebulin. Toxins, 12(9): 542. DOI: 10.3390/toxins12090542.
Schimidt HL, Garcia A, Martins A, Mello-Carpes PB, Carpes FP. 2017. Green tea supplementation produces better neuroprotective effects than red and black tea in Alzheimer-like rat model. Food Res Int, 100(1): 442-448. DOI: 10.1016/j.foodres.2017.07.026.
Scholey A, Downey LA, Ciorciari J, Pipingas A, Nolidin K, Finn M, Stough C. 2012. Acute neurocognitive effects of epigallocatechin gallate (EGCG). Appetite, 58(2): 767-770. DOI: 10.1016/j.appet.2011.11.016.
Siddiqui IA, Adhami VM, Ahmad N, Mukhtar H. 2010. Nanochemoprevention: Sustained release of bioactive food components for cancer prevention. Nutrition and Cancer. NIH Public Access. DOI: 10.1080/01635581.2010.509537.
Swanson KS, Gibson GR, Hutkins R, Reimer RA, Reid G, Verbeke K, Sanders ME. 2020. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nature Reviews Gastroenterology and Hepatology. Nature Res. DOI: 10.1038/s41575-020-0344-2.
Taghizadeh M, Farzin N, Taheri S, Mahlouji M, Akbari H, Karamali F, Asemi Z. 2017. The effect of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles in overweight women: A randomized double-blind placebo-controlled clinical trial. Annals of Nutri and Metabol, 70(4): 277-285. DOI: 10.1159/000471889.
Tang GY, Zhao CN, Xu XY, Gan RY, Cao SY, Liu Q, Li H. 2019. Phytochemical composition and antioxidant capacity of 30 Chinese teas. Antioxidants, 8(6): 180. DOI: 10.3390/antiox8060180.
Tang J, Zheng JS, Fang L, Jin Y, Cai W, Li D. 2015. Tea consumption and mortality of all cancers, CVD and all causes: A meta-analysis of eighteen prospective cohort studies. British J Nutri, 114(5): 673-683. DOI: 10.1017/S0007114515002329.
Tang P, Shen DY, Xu YQ, Zhang XC, Shi J, Yin JF. 2018. Effect of fermentation conditions and plucking standards of tea leaves on the chemical components and sensory quality of fermented juice. J Chem, 2018: 1-7. DOI: 10.1155/2018/4312875.
TBSA. 2017. Türkiye beslenme ve sağlık araştırması. URL: http://library1.nida.ac.th/termpaper6/sd/2554/19755.pdf (erişim tarihi: 02.01.2021).
TÜİK. 2020a. Ölüm ve ölüm nedeni istatistikleri, 2019: ss. 7–12. URL: https://data.tuik.gov.tr/ (erişim tarihi: 08.01.2021).
TÜİK. 2020b. İstatistiklerle Yaşlılar, 2019. URL: https://data.tuik.gov.tr/Bulten/Index?p=Istatistiklerle-Yaslilar-2019-33712 (erişim tarihi: 08.01.2021).
Wang J, Li P, Liu S, Zhang B, Hu Y, Ma H, Wang S. 2020. Green tea leaf powder prevents dyslipidemia in high-fat diet-fed mice by modulating gut microbiota. Food & Nutri Res, 64: DOI: 10.29219/fnr.v64.3672.
Wang L, Lee W, Cui YR, Ahn G, Jeon YJ. 2019. Protective effect of green tea catechin against urban fine dust particle-induced skin aging by regulation of NF-κB, AP-1, and MAPKs signaling pathways. Environ Pollution, 252: 1318-1324. DOI: 10.1016/j.envpol.2019.06.029.
Wang Li, Zeng B, Zhang X, Liao Z, Gu L, Liu Z, Fang X. 2016. The effect of green tea polyphenols on gut microbial diversity and fat deposition in C57BL/6J HFA mice. Food and Function, 7(12): 4956-4966. DOI: 10.1039/c6fo01150k.
WHO. 2017. Cardiovascular diseases (CVDs). URL: https://www.who.int/en/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) (erişim tarihi: 25.02.2021).
WHO. 2020a. The top 10 causes of death. who.int. 26 Aralık 2020 tarihinde URL: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death (erişim tarihi: 26.12.2020).
WHO. 2020b. Air pollution. URL: https://www.who.int/health-topics/air-pollution#tab=tab_1 (erişim tarihi: 26.12.2020).
Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipič M, Wright M. 2018. Scientific opinion on the safety of green tea catechins. EFSA J, 16(4): 89. DOI: 10.2903/j.efsa.2018.5239.
Yu S, Zhu L, Wang K, Yan Y, He J, Ren Y. 2019. Green tea consumption and risk of breast cancer. Medicine, 98(27): e16147. DOI: 10.1097/MD.0000000000016147.
Yuan X, Long Y, Ji Z, Gao J, Fu T, Yan M, Shao Z. 2018. Green tea liquid consumption alters the human intestinal and oral microbiome. Molecular Nutri and Food Res, 62(12): e1800178. DOI: 10.1002/mnfr.201800178.
Zhou T, Zhu M, Liang Z. 2018. (-)-Epigallocatechin-3-gallate modulates peripheral immunity in the MPTP-induced mouse model of Parkinson’s disease. Molecular Medicine Rep, 17(4): 4883-4888. DOI: 10.3892/mmr.2018.8470.