İndirgenmiş Grafen Oksit Modifiye Yüzey Baskılı Karbon Elektrotlar Kullanılarak Beta-Bloker İlaçların Elektrokimyasal Davranışının Araştırılması

Bu çalışmada, propranololün elektrokimyasal davranışı, indirgenmiş grafen oksit (rGO) ile modifiye edilmiş yüzey baskılı karbon elektrotlar (SPCE) ile incelenmiştir. Oksidasyon işlemi, döngüsel voltametri (CV) ve diferansiyel puls voltametri (DPV) teknikleri kullanılarak gerçekleştirilmiştir. Sonuçlar, rGO'nun oksidasyon pik akımını artırarak bu ilaçları uygun potansiyellerde oksitlediğini göstermiştir. Modifiye edilmiş SPCE, beta-blokerlerin, fosfat tampon çözeltisinde (PBS) alışılmadık derecede pozitif bir potansiyelde oksidasyonuna doğru mükemmel katalitik aktivite sergilemiştir. Propranololün tespiti için önerilen sensörün doğrusal konsantrasyon aralığı ve tespit limiti, sırasıyla, 50 µM ve 2.61 µM olarak elde edilmiştir.

An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes

In this study, the electrochemical behavior of propranolol was investigated on screen printed electrodes (SPCE)with reduced graphene oxide (rGO). Oxidation process, cyclic voltammetry (CV) and differential pulsevoltammetry (DPV) techniques were conducted by using measurements. The results showed that rGO increasedthe oxidation rate by increasing the peak current, and therefore oxidizing these drugs at appropriate potentials. Themodified SPCE exhibited excellent catalytic activity towards oxidation of the beta-blockers at an unusuallypositive potential in phosphate buffer solution (PBS). The linear concentration range and the detection limit of theproposed sensor for the detection of propranolol was 5- 50 µM and 2.61 µM, respectively

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