Özer BARAN, Aykut AYKAÇ, Coşkun KAYA, Habibullah AKTAŞ

Onikomikoz ve Erektil Disfonksiyon. Ortak Etiyoloji Birlikteliğe Neden Olur mu?

Amaç: Erektil Disfonksiyon (ED) ile Onikomikoz (OM) hastalığının birlikte görülme sıklığını saptamaya çalıştık. Gereç ve Yöntemler: Nisan 2019 - Nisan 2020 tarihleri arasında Karabük Üniversitesi Tıp Fakültesi Üroloji Polikliniği’ne ED şikâyeti ile başvuran erkek hastalara sosyodemografik form ve IIEF-5 formu doldurtuldu. ED saptanan hastalar çalışmaya dahil edildi. Tüm erkekler ED ciddiyetine göre hafif, orta, ciddi olmak üzere üç gruba ayrıldı. Dermatoloji uzmanı (H.A.) erkeklerin ayak tırnaklarından örnek alıp OM mevcudiyetini araştırdı. Bulgular: Çalışmaya kabul edilen 95 hastanın IIEF-5 skorlarına bakılarak 22’sinde (%23.1) hafif, 20’sinde (%21) orta ve 53’ünde (%55.9) ciddi düzeyde ED bulunduğu saptandı. Sigara kullanma öyküsü ciddi ED grubunda daha fazla idi (p 0.114). Sonuç: Erektil disfonksiyon ile OM hastalığı sıklıkla bir arada görülebilmektedir. Ancak ED şiddeti ile bir ilişkisi saptanmamıştır.

Onychomycosis and Erectile Dysfunction. Does Common Etiology Cause Togetherness?

Aim: We tried to determine the frequency of co-occurrence of erectile dysfunction (ED) and Onychomycosis (OM). Material and Methods: The sociodemographic form and IIEF-5 form were filled by the male patients who were admitted to the Urology Polyclinic of Karabük University Medical Faculty with the complaints of ED between April 2019 - April 2020. The patients with ED were included in the study. All the male patients were divided into three groups as mild, moderate and severe according to ED severity. The dermatologist (H.A) examined the presence of OM by taking samples from the toenails of the male patients. Results: Looking at the IIEF-5 scores of 95 patients accepted to the study, it was found that 22 (23.1%) had mild, 20 (21%) moderate and 53 (55.9%) severe ED. Smoking history was higher in the severe ED group (p 0.114). Conclusion: Erectile dysfunction and OM disease can often be seen together. However, no relationship was found with the severity of ED.

PDF

___

1. Gandaglia G, Briganti A, Jackson G, Kloner RA, Montorsi F, Montorsi P, Vlachopoulos C. A systematic review of the association between erectile dysfunction and cardiovascular disease. Eur Urol 2014;65:968-978.
2. Maas R, Schwedhelm E, Albsmeier J, Boger RH: The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function. Vasc Med 2002; 7: 213-215.
3. Sigurgeirsson B, Baran R. The prevalence of onychomycosis in the global population - A literature study. J Eur Acad Dermatol Venereol 2014;28(11):1480-1491.
4. Kampoli AM, Tousoulis D, Briasoulis A, Latsios G, Papageorgiou N, Stefanadis C. Potential pathogenic infl ammatory mechanisms of endothelial dysfunction induced by type 2 diabetes mellitus. Curr Pharm Des 2011;17: 4147-4158.
5. Tousoulis D, Kampoli AM, Stefanadis C. Diabetes mellitus and vascular endothelial dysfunction: Current perspectives. Curr Vasc Pharmacol 2012;10:19-32.
6. Jude EB, Eleftheriadou I, Tentolouris N. Peripheral arterial disease in diabetes - a review. Diabet Med 2010; 27: 4-14.
7. Ferket BS, Spronk S, Colkesen EB, Hunink MG. Systematic review of guidelines on peripheral artery disease screening. Am J Med 2012;125:198-208.
8. Gupta AK, Gupta MA, Summerbell RC, Cooper EA, Konnikov N, Albreski D, MacDonald P, Harris KA. The epidemiology of onychomycosis: possible role of smoking and peripheral arterial disease. J Eur Acad Dermatol Venereol 2000;14:466- 469.
9. Hotaling JM, Walsh TJ, Macleod LC, Heckbert S, Pocobelli G, Wessells H, White E. Erectile dysfunction is not independently associated with cardiovascular death: Data from the vitamins and lifestyle (VITAL) study. J Sex Med 2012; 9: 2104-2110.
10. Nehra A, Jackson G, Miner M, Billups KL, Burnett AL, Buvat J, Carson CC, Cunningham GR, Ganz P, Goldstein I, Guay AT, Hackett G, Kloner RA, Kostis J, Montorsi P, Ramsey M, Rosen R, Sadovsky R, Seftel AD, Shabsigh R, Vlachopoulos C, Wu FC. The Princeton III consensus recommendations for the management of erectile dysfunction and cardiovascular disease. Mayo Clin Proc 2012; 87:766-778.
11 Spessoto LC, Facio FN Jr, de Arruda JG, Arruda PF, Gatti M, Antoniassi TS, Facio MF, de Godoy JM. Association of hypertension with erectile function in chronic peripheral arterial insufficiency patients. J Clin Med Res 2016;8(8):582-584.
12. G* Power Ver. 3.0.10, Franz Faul. Kiel University, Deutschland Available: https://www.psychologie.hhu.de/arbeitsgruppen/ allgemeine-psychologie-und-arbeitspsychologie/gpower
13. Giuliano F. New horizons in erectile and endothelial dysfunction research and therapies. Int J Impot Res 2008; 20:2-8.
14. Fukunaga A, Washio K, Ogura K, Taguchi K, Chiyomaru K, Ohno Y, Masaki T, Nagai H, Nagano T, Oka M, Nishigori C. Onychomycosis as a warning sign for peripheral arterial disease. Acta Derm Venereol 2013;93:747-748.
15. Çinar Ö, Bolat MS. Erektil disfonksiyon hastalarına multidisipliner yaklaşım gerekir mi? Türk Diyab Obez 2020;3: 239-243.
16. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Magid D, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Nichol G, Paynter NP, Schreiner PJ, Sorlie PD, Stein J, Turan TN, Virani SS, Wong ND, Woo D, Turner MB; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2013 update: A report from the American Heart Association. Circulation 2013;127: 6-245.
17. Dong JY, Zhang YH, Qin LQ. Erectile dysfunction and risk of cardiovascular disease: Meta-analysis of prospective cohort studies. J Am Coll Cardiol 2011;58:1378-1385.
18. Kumagai H, Yoshikawa T, Myoenzono K, Kosaki K, Akazawa N, Asako ZM, Tsujimoto T, Kidokoro T, Tanaka K, Maeda S. Sexual function is an indicator of central arterial stiffness and arterial stiffness gradient in Japanese adult men. J Am Heart Assoc 2018;7(10).e007964.
19. Montorsi P, Ravagnani PM, Galli S, Rotatori F, Veglia F, Briganti A, Salonia A, Dehò F, Rigatti P, Montorsi F, Fiorentini C. Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: The COBRA trial. Eur Heart J 2006;27:2632-2639.
20. Shin D, Pregenzer G, Gardin JM. Erectile dysfunction: A disease marker for cardiovascular disease. Cardiol Rev 2011; 19: 5-11.
21. Scher RK, Rich P, Pariser D, Elewski B. The epidemiology, etiology, and pathophysiology of onychomycosis. Semin Cutan Med Surg 2013;32(2 Suppl 1):S2-4.
22. Blumentals WA, Gomez-Caminero A, Joo S, Vannappagari V. Is erectile dysfunction predictive of peripheral vascular disease? Aging Male 2003;6(4):217-221.
23. Onalan O, Adar A, Keles H, Ertugrul G, Ozkan N, Aktas H, Karakaya E. Onychomycosis is associated with subclinical atherosclerosis in patients with diabetes. Vasa 2015;44:59-64.
24. Ozkan F, Ozturk P, Ozyurt K, İncı MF, Kalender AM, Bakan B, Yuksel M. Frequency of peripheral arterial disease and venous insufficiency in toenail onychomycosis. J Dermatol 2013;40: 107-110.
25. Ermertcan AT, Temeltaş G. Dermatologic diseases and their effects on male sexual functions. J Dtsch Dermatol Ges 2010; 8: 592-597.
26. Goulding JM, Price CL, Defty CL, Hulangamuwa CS, Bader E, Ahmed I. Erectile dysfunction in patients with psoriasis: Increased prevalence, an unmet need, and a chance to intervene. Br J Dermatol 2011;164:103-109.
27. Duarte GV, Calmon H, Radel G, de Fátima Paim de Oliveira M. Psoriasis and sexual dysfunction: links, risks, and management challenges. Psoriasis (Auckl) 2018;8:93-99.