Seher ÇETİNKAYA ALTUNTAŞ, Ömercan TOPALOĞLU

Differansiye Tiroid Kanserli Hastalarda TSH Düzeylerine Göre Ortalama Platelet Volümü, Platelet Dağılım Genişliği, Nötrofil/ Lenfosit Oranı, Platelet/Lenfosit Oranı ve Lenfosit/Monosit Oranının Karşılaştırılması

Amaç:Diferansiye tiroid kanseri (DTK) standart tedavi total tiroidektomi ve sonrasında ömür boyu levotiroksin (LT4) replasmanı yapılmasıdır. Fakat ekzojen LT4 ile TSH düzeyinin ne olması gerektiği halen tartışma konusudur. Gereç ve Yöntemler: Prospekif non metastatik DTK tanısı olan 162 hasta ile 69 sağlıklı gönüllü alındı. DTK hastaları TSH seviyesine göre 3 gruba ayrıldı. TSH: 0,1μIU/mLden küçük ise suprese tirotropin TSH:0,11-0,49 μIU/mLarasında ise ılımlı suprese tirotropin TSH :0,5- 2μIU/mL arasında düşük -normal tirotropin grubu olarak adlandırıldı. Bulgular:DTK ve sağlıklı kontrol grubu arasında MPV, PDW, NLR,PLR, LMR arasında istatistiksel fark saptanmadı.HastalarTSH düzeyine göre 3 gruba ayrılınca sadece PDW düzeyleri diğer 3 gruba göre ılımlı suprese grupta yüksek saptandı. (p

Anahtar Kelimeler:

Differansiye Tiroid Kanser ;, Ortalama Platelet Volümü, Ortalama Platelet Dağılımı

Comparison of Mean Platelet Volume, Platelet Distribution Width, Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Lymphocyte/Monocyte Ratio in Patients with Differentiated Thyroid Cancer According to TSH Levels

Purpose: The standard treatment in differentiated thyroid cancer (DTC) is total thyroidectomy followed by lifelong levothyroxine (LT4) replacement. However, what should be the level of exogenous LT4 and TSH is still a matter of debate. Material and Method: 162 patients with a prospective diagnosis of non-metastatic DTC and 69 healthy volunteers were included. DTC patients were divided into 3 groups according to their TSH level. If TSH is less than 0.1μIU/mL, between 0.11-0.49 μIU/mL, 0.5-2μIU/mL, the groups were named as suppressed thyrotropin, moderately suppressed thyrotropin and low-normal thyrotropin group, respectively. Results: No statistical difference was observed between MPV, PDW, NLR, PLR, LMR when the DTC group and the healthy control group were compared. When the patients were divided into 3 groups according to their TSH levels, only PDW levels were found to be higher in the moderately suppressed group compared to the other groups (p

Keywords:

Mean Platelet Volüme;, Differantieted Thyroid Cancer ;, Platelet Distrubition Width,

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