Successful treatment of refractory gastrointestinal bleeding by systemic (oral) ankaferd blood stopper in a patient with glanzmann thrombasthenia

Successful treatment of refractory gastrointestinal bleeding by systemic (oral) ankaferd blood stopper in a patient with glanzmann thrombasthenia

Background: Glanzmann Thrombasthenia (GT) is agenetic platelet dysfunction and a life threatening dis- ease. Ankaferd Blood Stopper (ABS) is a topical he- mostatic agent of herbal origin which has been recentlymade available for clinical use. Its hemostatic effect isindependent from blood clotting factors and occurs as aresult of the aggregation of focal red blood cells by anencapsulated protein web. Case Report: In this paper, a patient with GT is pre- sented in whom 3 months of gastrointestinal bleeding refractory to all medical therapies was controlled with-in a short time of using oral ABS.Conclusion: The difference between this patient andother cases presented in the medical literature is the oraluse of ABS. Thus, this patient may contribute to the medi-cal community in showing the safety and efficacy of sys-temic (oral) ABS in patients with disorders of coagulation.However, there is a need for more patient experiences.

___

  • 1. Franchini M, Favaloro EJ, Lippi G. Glanzmann thrombasthenia: an update. Clin Chim Acta 2010;41:1-6. [CrossRef]
  • 2. Beyazit Y, Kurt M, Kekilli M, Goker H, Haznedaroglu IC. Eval- uation of hemostatic effects of Ankaferd as an alternative medi- cine. Altern Med Rev 2010;15:329-36.
  • 3. Beyazit Y, Kekilli M, Haznedaroglu IC, Kayacetin E, Basaranoglu M. Ankaferd hemostat in the management of gastrointestinal hem- orrhages. World J Gastroenterol 2011;17:3962-70. [CrossRef]
  • 4. Beyazit Y, Kart T, Kuscu A, Arslan A, Kurt M, Aktas B, et al. Successful management of bleeding after dental procedures with application of blood stopper: a single center prospective trial. J Contemp Dent Pract 2011;12:379-84. [CrossRef]
  • 5. Bakdash S, Lyons JM, Bastacky SI, Pezzone MA, McGee JB, Schoen RE, et al. Management of persistent gastric bleeding in a patient with Glanzmann’s thrombasthenia. Am J Hematol 2008;83:411-5. [CrossRef]
  • 6. Bhat S, Yadav SP, Anjan M, Dinand V, Sachdeva A. Recombinant activated factor VII usage in life threatening hemorrhage: a pedi- atric experience. Indian J Pediatr 2011;78:961-8. [CrossRef]
  • 7. Kazancıoğlu HO, Cakır O, Ak G, Zülfkar B. The Effectiveness of a New Hemostatic Agent (Ankaferd Blood Stopper) for the Con- trol of Bleeding following Tooth Extraction in Hemophilia: A Con- trolled Clinical Trial. Turk J Haematol 2013;30:19-24. [CrossRef]
  • 8. Baykul T, Alanoglu EG, Kocer G. Use of Ankaferd Blood Stop- per as a hemostatic agent: a clinical experience. J Contemp Dent Pract 2010;11:88-94.
  • 9. Solak Y, Gaipov A, Ozbek O, Hassan MA, Yeksan M. Massive haematuria successfully managed by intravesical Ankaferd in a haemodialysis patient complicated with disseminated intravas- cular coagulation. BMJ Case Rep 2012;2012.
  • 10. Ozseker B, Shorbagi A, Efe C, Haznedaroglu IC, Bayraktar Y. Control- ling of upper gastrointestinal bleeding associated with severe immune thrombocytopenia via topical adjunctive application of Ankaferd blood stopper. Blood Coagul Fibrinolysis 2012;23:464. [CrossRef]
  • 11. Sonmez M, Baltacioğlu E, Sarac O, Erkut N. The use of Ankaferd blood stopper in a patient with Glanzmann’s thrombasthenia with gingival bleeding. Blood Coagul Fibrinolysis 2010;21:382-83. [CrossRef]
  • 12. Leblebisatan G, Bay A, Karakus SC, Kekilli M, Haznedaroglu IC. Topical Ankaferd hemostat application for the management of oral cavity bleedings in children with hemorrhagic diathesis. Blood Coagul Fibrinolysis 2012;23:494-97. [CrossRef]
  • 13. Akbal E, Köklü S, Astarcı HM, Koçak E. Oral high-dose ankaf- erd administration effects on gastrointestinal system. Int J Med Sci 2013;10:451-6. [CrossRef]
  • 14. Kurt M, Oztas E, Kuran S, Onal IK, Kekilli M, Haznedaroglu IC. Tandem oral, rectal, and nasal administrations of Ankaferd Blood Stopper to control profuse bleeding leading to hemody- namic instability. Am J Emerg Med 2009;27:631. [CrossRef]
Balkan Medical Journal-Cover
  • ISSN: 2146-3123
  • Yayın Aralığı: 6
  • Başlangıç: 2015
  • Yayıncı: Galenos Yayınevi
Sayıdaki Diğer Makaleler

Aripiprazole induced acute transient bilateral myopia: A case report

Mutlu ACAR, Kadir ÖZDEL, Hasan KARADAĞ

Detection of human bocavirus dna by multiplex pcr analysis: Postmortem case report

Taner DAŞ, Neval ELGÖRMÜŞ, Gözde ŞİRİN, Nihan ZİYADE

The reflection of plication surgery for diaphragm eventration to respiratory function test

Ertan AYDIN, Nurettin KARAOĞLANOĞLU, Ülkü YAZICI, Serdar ÖZKAN

Protective effect of alpha lipoic acid on rat sciatic nerve ischemia reperfusion damage

Ozan TURAMANLAR, Sezer AKÇER, Murat YAĞMURCA, Oğuz Aslan ÖZEN, Ahmet SONGUR, Hakan MOLLAOĞLU, Cevat AKTAŞ

Paraoxonase 1 activity and survival in sepsis patients

Bilgin CÖMERT, Volkan İNAL, Gürhan TAŞKIN, Serkan TAPAN, Levent YAMANEL

Characterization of the interleukin-28b gene rs12979860 c/t polymorphism in Turkish chronic hepatitis c patients and healthy ındividuals

Halit CANATAN, Orhan YILDIZ, Keziban KORKMAZ, Serpil TAHERİ, Bilgehan AYGEN, Gökmen ZARARSIZ

Successful treatment of refractory gastrointestinal bleeding by systemic (oral) ankaferd blood stopper in a patient with glanzmann thrombasthenia

Sibel HACIOĞLU KABUKÇU, Ali KESKİN, İsmail SARI, Mehmet Hilmi DOĞU

Brafv600e mutation, ret/ptc1 and pax8-ppar gamma rearrangements in follicular epithelium derived thyroid lesions-institutional experience and literature review

Binnur ÖNAL, Ahmet ŞAHPAZ, Ahmet YEŞİLYURT, Tuncay DELİBAŞI, Ünsal HAN

Inferior phrenic arteries and their branches, their anatomy and possible clinical importance: An experimental cadaver study

İlke Ali GÜRSES, Ayşin KALE, Adnan ÖZTÜRK, Ahmet USTA, Kayıhan ŞAHİNOĞLU, Özcan GAYRETLİ

A comparison of the effects of different types of laryngoscope on the cervical motions: randomized clinical trial

Ali YILMAZ, Alkin ÇOLAK, Elif ÇOPUROĞLU, Sevtap ŞAHİN HEKİMOĞLU, Nesrin TURAN