Yahya ÇELİK, Özlem BİRGİLİ, Aslı KİYAT, Baburhan GÜLDİKEN, Hülya ÖZKAN, Hakan YILMAZ, Sebahattin SAİP, Dilek KUŞÇU, Nevin SÜTLAS, Jale AĞAOĞLU, Ufuk UTKU, Aksel SİVA

Prevalence of Multiple Sclerosis in the Metropolitan Area of Edirne City, Turkey

Objective: The prevalence and incidence of multiple sclerosis may vary according to the influence of the altitude of a geographical area as well as the genetic and environmental factors. This study ained to determine the incidence and prevalence of multiple sclerosis in Edirne population. Material and Methods: Patients with a definite diagnosis of MS according to McDonald&#39;s criteria, admitted to one of the three MS clinics in Edirne, were included in this two-stage study. Also the records of hospitals in İstanbul serving patients from Edirne, have been evaluated. Results: The prevalence rate of confirmed MS patients was 33.9/100000 (95% CI: 32-36) in 2003. The mean annual incidence was 3.48/100000 (95% CI: 2.90-4.00). Mean age of the patients was 36.5&plusmn;9.6 years. Mean age at onset was 29.2&plusmn;8.5 years. Mean duration of disease was 6.9&plusmn;5.2 years. Overall, 69.2% had a relapsing-remitting course, 20.5% had a primary progressive course and 10.3% had a secondary progressive course. Mean Expanded Disability Status Scale score was 3.04&plusmn;2.18. The prevalence and annual incidence after one year was 36.5 per 100000 (95% CI: 33.2-38.6) and 2.60 per 100000 (95% CI: 2.1-3.8), respectively. Conclusion: This is the first city-based MS prevalence study performed in Turkey. The MS prevalence in Edirne is similar to that of Greece and Bulgaria but lower than that of European countries.

Keywords:

Multiple Sclerosis, prevalance, incidence, epidemiology, Turkey,

PDF

___

Ebers GC, Sadovnick AD. Epidemiology. In Paty DW, Ebers GC eds. Multiple sclerosis. Philedelphia: FA Davis 1998;5-28.
Rosati G, Granieri E, Carreras M, Tola R. Multiple sclerosis in southern Europe: a prevalence study in the sociosanitary district of Copparo, northern Italy. Acta Neurol Scand 1980;62:244-9. [CrossRef]
Dean G, Aksoy H, Akalin T, Middleton L, Kyriallis K. Multiple Scle- rosis in the Turkish- and Greek-speaking communities of Cyprus. J Neurol Sci 1997;145:163-8. [CrossRef]
Granieri E, Malagu S, Casetta I, Tola MR, Govoni V, Paolino E, et al. Multiple sclerosis in Italy. Arch Neurol 1996;53:793-8. [CrossRef]
Casquero P, Villoslada P, Montalban X, Torrent M. Frequency of multiple sclerosis in Menorca, Balearic Islands, Spain. Neuroepi- demiology 2001;20:129-33. [CrossRef]
BuŞ ll E, Blesa R, Galan I, Dean G. Prevalence of multiple sclerosis in the region of Osona, Catalonia, northern Spain. J Neurol Neu- rosurg Psychiatry 1995;58:577-81. [CrossRef]
Benito-Leon J, Martin E, Vela L, Villar ME, Felgueroso B, Marrero C, et al. Multiple sclerosis in Mostoles, central Spain. Acta Neurol Scand 1998;98:238-42.
Granieri E, Casetta I, Govoni V, Tola MR, Marchi D, Murgia SB, et al. The increasing incidence and prevalence of MS in a Sardinian province. Neurology 2000;55:842-8.
Grimaldi LM, Salemi G, Grimaldi G, Rizzo A, Marziolo R, Lo Presti C, et al. High incidence and increasing prevalence of MS in Enna (Sicily), southern Italy. Neurology 2001;57:1891-3.
Piperidou HN, Heliopoulos IN, Maltezos ES, Milonas IA. Epide- miological data of multiple sclerosis in the province of Evros, Greece. Eur Neurol 2003;49:8-12. [CrossRef]
Milanov I, Georgiev D, Kmetska K, Jordanova L, Topalov N. Prevalence of Multiple Sclerosis in Bulgaria. Neuroepidemiology 1997;16:304-7. [CrossRef]
Georgiev D, Milanov I, Tzonev V, Kalafatova O. The epidemiol- ogy of multiple sclerosis in SoŞ a. In Firnhaber W, Lauer K eds. Multiple Sclerosis in Europe. An Epidemiological Update. Als- bach: Leuchttrum-Verlag/LTV Press, 1994;322-5.
Milanov I, Topalov N, Kmetski T. Prevalence of multiple sclerosis in Gypsies and Bulgarians. Neuroepidemiology 1999;18:218-22. [CrossRef]
Etemadifar M, Janghorbani M, Shaygannejad V, Ashtari F. Preva- lence of multiple sclerosis in Isfahan, Iran. Neuroepidemiology 2006;27:39-44. [CrossRef]
Celik Y, Birgili O, Kiyat A, Guldiken B, Yilmaz H, Saip S, et al. Prevalence of multiple sclerosis in the metropolitan area of Ed- irne city, Turkey. Multiple Sclerosis ECTRIMS 2003;211.
Turk Boru U, Alp R, Sur H, Gul L. Prevalence of multiple sclerosis door-to-door survey in Maltepe, Istanbul, Turkey. Neuroepidemi- ology 2006;27:17-21.
T.C. Basbakanlik Devlet Istatistik Enstitusu. 2000 Genel Nufus Sayimi. T.C. Basbakanlik Devlet Istatistik Enstitusu, 2000.
McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagno- sis of multiple sclerosis. Ann Neurol 2001;50:121-7. [CrossRef]
Kurtzke JF. Rating neurologic impairment in multiple scle- rosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-52. [CrossRef]
Pugliatti M, Rosati G, Carton H, Riise T, Drulovic J, Vecsei L, et al. The epidemiology of multiple sclerosis in Europe. Eur J Neurol 2006;13:700-22. [CrossRef]
Siva A, Uyanik O, Saip S, Tanik O, Agaoglu J, Isik N, et al. Preva- lence rate of multiple sclerosis in the jewish community in Istan- bul. J Neurologic Sciences 2005;238:S249. [CrossRef]
Karni A, Kahana E, Zilber N, Abramsky O, Alter M, Karussis D. The frequency of multiple sclerosis in jewish and arab populations in greater jerusalem. Neuroepidemiology 2003;22:82-6. [CrossRef]
Kalman B, Takacs K, Gyodi E, Kramer J, Fust G, Tauszik T, et al. Sclerosis multiplex in gypsies. Acta Neurol Scand 1991;84:181-5.
Middleton LT, Dean G. Multiple Sclerosis in Cyprus. J Neurol Sci 1991;103:29-36. [CrossRef]
Kantarci O, Siva A, Eraksoy M, Karabudak R, Sutlas N, Agaoglu J, et al. Survival and predictors of disability in Turkish MS patients. Turkish Mutiple Sclerosis Study Group (TUMSSG). Neurology 1998;51:765-72.
Weinshenker BG. The natural history of multiple sclerosis. Neurol Clin 1995;13:119-46.