Plamen GETSOV, Zhivko ZHELEV, Ichio AOKİ, Rumiana BAKALOVA

New Hypothesis and Alternative Approach for Imaging Neuronal Function and Metabolic Activity Based on Redox-Status

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1. Buxton RB. Introduction to Functional Magnetic Resonance Imaging: Principles and Techniques, 2nd ed. UK: Cambridge University Press; 2009.
2. Hyder F, Patel AB, Gjedde A, Rothman DL, Behar KL, Shulman RG. Neuronalglial glucose oxidation and glutamatergic-GABAergic function. J Cereb Blood Flow Metab 2006;26:865-77.
3. Sheng ZH, Cai Q. Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat Rev Neurosci 2012;13:77-93.
4. Andrews ZB, Diano S, Horvath TL. Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat Rev Neurosci 2005;6:829-40.
5. Berkowitz BA, Bredell BX, Davis C, Samardzija M, Grimm C, Roberts R. Measuring in vivo free radical production by the outer retina. Invest Ophthalmol Vis Sci 2015;56:7931-8.
6. Maulucci G, Bacic G, Bridal L, Schmidt HH, Tavitian B, Viel T, et al. Imaging reactive oxygen species-induced modifications in living systems. Antioxid Redox Signal 2016;24:939-58.
7. Logothetis NK, Wandell BA. Interpreting the BOLD signal. Annu Rev Physiol 2004;66:735-69.
8. Lourenco CF, Ledo A, Barbosa RM, Laranjinha J. Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration. Free Radic Biol Med 2017;108:668-82.
9. Yamato M, Shiba T, Yamada K, Watanabe T, Utsumi H. Noninvasive assessment of the brain redox status after transient middle cerebral artery occlusion using Overhauserenhanced magnetic resonance imaging. J Cereb Blood Flow Metab 2011;29:1655-64.