Mixed Adeno-Neuroendocrine Carcinoma; Case Series of Ten Patients with Review of the Literature
Mixed Adeno-Neuroendocrine Carcinoma; Case Series of Ten Patients with Review of the Literature
Aims: Mixed adeno-neuroendocrine carcinoma is a rare entity,diagnosed with immunohistochemical studies. Literature mainlyincludes case reports and series which are very few. In our study, weaimed to report a case series from a tertiary hospital with demographicsof the patients, detailed tumor and clinical findings and follow-up plussurvival conditions.Methods: Pathology database was explored for patients with thepathological diagnosis of ‘mixed adeno-neuroendocrine carcinoma’and patients were identified retrospectively and evaluated in meansof demographics, histopathological examination, tumor properties.Results: Ten patients had been diagnosed with mixed adenoneuroendocrinecarcinoma in our center, diagnosed at a mean age of64.7. Stomach was found to be the most common localization. Fivepatients (50%) were diagnosed as grade 3. Following surgery, medianfollow-up was 15 months with a median survival time of 20.6 months.Conclusion: This case series may contribute to the literature on thepathological and clinical aspects of the mixed adenoneuroendocrinecarcinoma of the gastrointestinal system.
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- Volante M, Rindi G, Papotti M. The grey zone between pure (neuro) endocrine and
non- (neuro) endocrine tumours: a comment on concepts and classification of mixed
exocrine-endocrine neoplasms. Wirchows Arch 2006;449:499-506.
- Veits L, Lang-Schwarz C, Volkholz H, Falkeis C, Vieth M, Schulz H. Mixed
adenoneuroendocrine carcinoma (MANEC) of the esophagogastric junction
predominantly consisting of poorly differentiated neuroendocrine carcinoma.
Endoscopy 2013;45(Suppl 2):16-7.
- Juanmartinena JF, Fernandez-Urien I, Cordoba A, Miranda C, Borda A. Mixed
adenoneuroendocrine carcinoma (MANEC) of the gastroesophageal junction: a case
report and review of the literature. Rev Esp Enferm Dig 2017;109:160-2.
- La Rosa S, Marando A, Furlan D, Sahnane N, Capella C. Colorectal poorly
differentiated neuroendocrine carcinomas and mixed aenoneuroendocrine carcinomas:
insights into the diagnostic immunophenotype, assesment of methylation profile, and
search for prognostic markers. Am J Surg Pathol 2012;36:601-11.
- Murata M, Takahashi H, Yamada M, Song M, Hiratsuka M. A case of mixed
adenoneuroendocrine carcinoma of the pancreas. Immunohistochemical analysis for
histogenesis. Medicine (Baltimore) 2017;96:e6225.
- Song W, Chen W, Zhang S, Peng J, He Y. Successful treatment of gallbladder mixed
adenoneuroendocrine carcinoma with neo-adjuvant chemotherapy. Diagn Pathol
2012;7:163.
- Brathwaite S, Rock J, Yearsley MM, Bekaii-Saab T, Wei L, Frankel WL, et al. Mixed
adeno-neuroendocrine carcinoma: an aggressive clinical entity. Ann Surg Oncol
2016;23:2281-6.
- Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell
Physiol 2000;182:311-22.
- Chen MH, Kuo YJ, Yeh YC, Lin YC, Tzeng CH, Liu CY, et al. High neuroendocrine
component is a factor for poor prognosis in gastrointestinal high-grade malignant
mixed adenoneuroendocrine neoplasms. J Chin Med Assoc 2015;78:454-9.
- Acosta AM, Wiley EL. Primary biliary mixed adenoneuroendocrine carcinoma
(MANEC). A short review. Arch Pathol Lab Med 2016;140:1157-62.
- Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK.
Ampullary mixed adenoneuroendocrine carcinoma: surprise histology, familiar
management. Int J Surg Pathol 2017;7:585-91.
- Solcia E, Klöppel G, Sobin LH. Histopathological Typing of Endocrine Tumours. 2nd
ed. Berlin, Germany: Springer; 2000.
- Acosta AM, Hamedani FS, Kajdacsy-Balla A, Wiley EL. Primary Mixed
Adenoneuroendocrine Carcinoma of the Gallbladder in a 55-Year-Old Female
Patient: A Case Report and Review of the Literature. Int J Surg Pathol 2015;23:414-8.
- Liu XJ, Feng JS, Xiang WY, Kong B, Wang LM, Zeng JC, et al. Clinicopathological
features of an ascending colon mixed adenoneuroendocrine carcinoma with clinical
serosal invasion. Int J Clin Exp Pathol 2014;7:6395-8.
- Gurzu S, Kadar Z, Bara T, Bara T Jr, Tamasi A, Azamfirei L, et al. Mixed
adenoneuroendocrine carcinoma of gastrointestinal tract: report of two cases. World J
Gastroenterol 2015;21:1329-33.
- Harada K, Sato Y, Ikeda H, Maylee H, Igarashi S, Okamura A, et al. Clinicopathologic
study of mixed adenoneuroendocrine carcinomas of heptobiliary organs. Wirchows
Arch 2012;460:281-9.
- La Rosa S, Marando A, Sessa F, Capella C. Mixed adenoneuroendocrine
carcinomas (MANECs) of the gastrointestinal tract: an update. Cancers (Basel)
2012;4:11-30.
- Lewin K. Carcinoid tumors and the mixed (composite) glandular-endocrine cell
carcinomas. Am J Surg Pathol 1987;11(Suppl 1):71-86.
- Cordier R. Les cellules argentaffines dans les tumeurs intestinales. Arch Int Med Exp
1924;1:5.
- Rindi G, Arnold R, Bosman FT, Capella C, Klimstra DS, Klöppel G, et al.
Nomenclature and classification of neuroendocrine neoplasms of the digestive system.
In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO Classification of
Tumours of the Digestive System. 4th ed. Lyon, France: IARC Press; 2010:13-4.