Grayanotoxin (Mad Honey) - Ongoing Consumption After Poisoning

Grayanotoxin (Mad Honey) - Ongoing Consumption After Poisoning

Background:Some honey types in certain geographical regions may cause toxic effects on people. This type of honey is known as "mad honey" in Turkey. The toxic ingredient of this honey is called Grayanotoxin I. The consumption of mad honey can cause severe bradycardia, hypotension, dizziness, nausea and vomiting.Aims: Our study is aimed at analysing patients diagnosed with mad honey poisoning and their behaviour towards the consumption of this honey after diagnosis. Study Design:Cross sectional study. Methods: This cross-sectional study was based on complaints and findings of mad honey poisoning. Patient information and findings at the time of admission were compared with those at one month after discharge through telephone interviews. They were asked if either they or their relatives had continued consuming the same honey. Frequency data such as gender, purpose of honey consumption, first complaints and continuance of honey consumption are shown as number (n) and percentage (%). A Chi Square test was conducted to determine the difference between groups.Results: 38 patients were participated in this study; 18 of the patients had to be followed up in a coronary intensive care unit. We were able to reach 34 patients by phone after discharge. It was found that 12 of 16 patients discharged after emergency unit observation or their close relatives were continuing to consume mad honey, whereas 16 (88.9%) of the 18 patients under coronary intensive care had discontinued consuming mad honey. The difference in the continuation of mad honey consumption between patient groups followed-up in the intensive care unit and those discharged after emergency observation was statistically significant.Conclusion: Hazards associated with and serious consequences following the consumption of mad honey must be clearly explained to patients who are found to be consuming mad honey.

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  • 1. Gokçel T. in: Xenophon; Anabasis, Onbinlerin Dönüşü. 2nd edn. Istanbul: Sosyal Yayınlar; 1984. p. 143-4.
  • 2. Sütlüpınar N, Mat A, Satganoğlu Y. Poisoning by toxic honey in Turkey. Arch Toxicol 1993;67:148-50. [CrossRef]
  • 3. Onat FY, Yegen BC, Lawrence R, Oktay A, Oktay S. Mad honey poisoning in man and rat. Rev Environ Health 1991;9:3-9. [CrossRef]
  • 4. Onat F, Yegen BC, Lawrence R, Oktay A, Oktay S. Site of action of grayanotoxins in mad honey in rats. J Appl Toxicol 1991;11:199- 201. [CrossRef]
  • 5. Gossinger H, Hruby K, Pohl A, Davogg S, Sutterlutti G, Mathis G. Poisoning with andromedotoxin-containing honey. Dtsch Med Wochenschr 1983;108:1555-8.
  • 6. Dilber E, Kalyoncu M, Yaris N, Okten A. A case of mad honey poisoning presenting with convulsion: intoxication instead of alternative therapy. Turk J Vet Anim Sci 2002;32:361-2.
  • 7. Yavuz H, Ozel A, Akkus I, Erkul I. Honey poisoning in Turkey. Lancet 1991;337:789-90. [CrossRef]
  • 8. Yilmaz O, Eser M, Sahiner A, Altintop L, Yesildag O. Hypotension, bradycardia and syncope caused by honey poisoning. Resuscitation 2006;68:405-8. [CrossRef]
  • 9. Gündüz A, Meriçé ES, Baydın A, Topbas M, Uzun H, Türedi S, et al. Does mad honey poisoning require hospital admission? Am J Emerg Med 2009;27:424-7. [CrossRef]
  • 10. Demircan A, Keleş A, Bildik F, Aygencel G, Doğan NO, Gómez HF. Mad honey sex: therapeutic misadventures from an ancient biological weapon. Ann Emerg Med 2009;54:824-9. [CrossRef]
  • 11. Ozhan H, Akdemir R, Yazici M, Gündüz H, Duran S, Uyan C. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004;21:742-4. [CrossRef]
  • 12. Gunduz A, Turedi S, Uzun H, Topbas M. Mad honey poisoning. Am J Emerg Med 2006;24:595-8. [CrossRef]
  • 13. Yildirim N, Aydin M, Cam F, Celik O. Clinical presentation of nonST-segment elevation myocardial infarction in the course of intoxication with mad honey. Am J Emerg Med 2008;26:108.e1-2.
  • 14. Gunduz A, Durmus I, Turedi S, Nuhoglu I, Ozturk S. Mad honey poisoning related asystole. Emerg Med J 2007;24:592-3. [CrossRef]
Balkan Medical Journal-Cover
  • ISSN: 2146-3123
  • Yayın Aralığı: 6
  • Başlangıç: 2015
  • Yayıncı: Galenos Yayınevi
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