Diagnostic Value of Procalcitonin Levels in Acute Mesenteric Ischemia
Diagnostic Value of Procalcitonin Levels in Acute Mesenteric Ischemia
Background: Acute mesenteric ischemia (AMI) is apotentially fatal disease. Difficulties in diagnosis makeit essential to find early biomarkers. Aims: This study investigated the diagnostic value ofprocalcitonin (PCT) levels in AMI. Study Design: Animal experimentation.Methods: Rats were divided into six groups of six ani- mals each. In the experimental group, an experimentalischemia model was established by clamping the su- perior mesenteric artery from the aortic outflow tract.Blood and tissue specimens were collected from rats inthe experimental mesenteric ischemia model at 30 minand 2 and 6 h, and these were compared with speci- mens from the respective control groups. PCT levelswere compared at 30 min and 2 and 6 h. Results: PCT levels were 185.3 pg/mL in the controlgroup and 219.3 pg/mL in the study group, 199.6 pg/ mL in the control group and 243.9 pg/mL in the studygroup, and 201.9 pg/mL in the control group and 286.9pg/mL in the study group, respectively, at 30 minute, 2and 6 hours. Significant differences were determinedbetween 6-h control group and ischemia group PCTlevels (p=0.005). Conclusion: The absence of a significant increase inPCT levels in the early period, while a significant dif- ference was detected in the later period (6 h), shows thatPCT levels rise late in mesenteric ischemia and can be amarker in the late period.
___
- 1. Menon NJ, Amin AM, Mohammed A, Hamilton G. Acute mes- enteric ischaemia. Acta Chir Belg 2005;105:344-54.
- 2. Yasuhara H. Acute mesenteric ischemia: the challenge of gastro- enterology. Surg Today 2005;35:185-95. [CrossRef]
- 3. Christopher MB. Fernandes Mesenteric Ischemia. http://www. emedicine.com/EMERG/topic311.htm. Accessed: 13.09.2006.
- 4. Carrol ED, Thomson AP, Hart CA. Procalcitonin as a marker of sepsis. Int J Antimicrob Agents 2002;20:1-9. [CrossRef]
- 5. Massaro KS, Costa SF, Leone C, Chamone DA. Procalcitonin (PCT) and C-reactive protein (CRP) as severe systemic infection markers in febrile neutropenic adults. BMC Inf ect Dis 2000;7:137. [CrossRef]
- 6. Burtis CA, Ashwood ER. Klinik Kimyada Temel İlkeler. Palme Yayınları, 5th Ed. Ankara, 2005, p. 450-2.
- 7. Assıcat M, Gendrel D, Carsin H, Raymond J, Guılbaud J, Bohu- on C. High serum procalcitonin concentrations in patients with sepsis and infections. Lancet 1993;341:515-8. [CrossRef]
- 8. Yasuhara H. Acute mesenteric ischemia: the challenge of gastro- enterology. Surg Today 2005;35:185-95. [CrossRef]
- 9. Kozuch PL, Brandt LJ. Review article: diagnosis and manage- ment of mesenteric ischaemia with an emphasis on pharmaco- therapy. Aliment Pharmacol Ther 2005;21:201-15. [CrossRef]
- 10. Lange H, Jackel R. Usefulness of plasma lactate concentra- tion in the diagnosis of acute abdominal disease. Eur J Surg 1994;160:381-4.
- 11. Kulaçoğlu H, Kocaerkek Z, Moran M, Kulah B, Atay Ç, Kulaçoğlu S. Diagnostic value of blood D-dimer level in acute mesenteric ischaemia in the rat: An experimental study. Asian J Surg 2005;28:131-5. [CrossRef]
- 12. Meyer T, Klein P, Schweiger H, Lang W. How can the prognosis of acute mesenteric artery ischemia be improved? Results of a retrospektive analysis. Zentralbl Chir 1998;123:230-4.
- 13. Acosta S, Ogren M, Sternby NH, Bergqvist D, Bjorck M. Clini- cal implications for the management of acute thromboembolic occlusion of the superior mesenteric artery: autopsy findings in 213 patients. Ann Surg 2005;241:516-22. [CrossRef]
- 14. Altinyollar H, Boyabatli M, Berberoglu U. D-dimer as a marker for early diagnosis of acute mesenteric ischemia. Thromb Res 2006;117:463-7. [CrossRef]
- 15. Kurt Y, Akin ML, Demirbas S, Uluutku AH, Gulderen M, Avsar K, Celenk T. D-dimer in the early diagnosis of acute mesenteric ischemia secondary to arterial occlusion in rats. Eur Surg Res 2005;37:216-9. [CrossRef]
- 16. Rau B, Steinbech G, Baum gart K, Gansauge F, Beger HG. The clinical value of procalcitonin in the prediction of infected ne- crosis in acute pancreatitis. Intensive Care Med 2000;26:159-64. [CrossRef]
- 17. Meisner M. Pathobiochemistry and clinical use of procalcitonin. Clin Chim Acta 2002;323:17-29. [CrossRef]
- 18. Becker KL, Nylen ES, Cohen R, Snider RH. Calcitonin: Structure, molecular biology, and actions. Principles of Bone Biology. Academic Press Inc.; 1996. p. 471-4.
- 19. Guven H, Altıntop L, Baydın A, Esen S. Diagnostic value of procalcitonin levels as an early indicator of sepsis. Am J Emerg Med 2002;20:202-6. [CrossRef]
- 20. Steinwald PM, Whang KT, Becker KL, Snider RH, Nylen ES, White JC. Elevated calcitonin precursor levels are related to mortal- ity in an animal model of sepsis. Crit Care 1999;3:11-6. [CrossRef]
- 21. Karabulut K, Gül M, Dündar ZD, Cander B, Kurban S, Toy H. Diagnostic and prognostic value of procalcitonin and phospho- rus in acute mesenteric ischemia. Ulus Travma Acil Cerrahi Derg 2011;17:193-8. [CrossRef]