İbrahim GÖKÇE, Harika ALPAY, Nurdan YILDIZ, Neslihan ÇİÇEK, Neşe BIYIKLI, Ülger ALTUNTAŞ, Serçin GÜVEN

Changes in Bacterial Resistance Patterns of Pediatric Urinary Tract Infections and Rationale for Empirical Antibiotic Therapy

Background: The causative agent spectrum andresistance patterns of urinary tract infections in childrenare affected by many factors.Aims: To demonstrate antibiotic resistance in urinarytract infections and changing ratio in antibiotic resistanceby years.Study Design: Retrospective cross-sectional study.Methods: We analysed antibiotic resistance patterns ofisolated Gram (-) bacteria during the years 2011-2014(study period 2) in children with urinary tract infections.We compared these findings with data collected in thesame centre in 2001-2003 (study period 1).Results: Four hundred and sixty-five uncomplicatedcommunity-acquired Gram (-) urinary tract infectionswere analysed from 2001-2003 and 400 from 2011-2014. Sixty-one percent of patients were female (1.5girls : 1 boy). The mean age of children included in thestudy was 3 years and 9 months. Escherichia coli wasthe predominant bacteria isolated during both periodsof the study (60% in study period 1 and 73% in studyperiod 2). Bacteria other than E. coli demonstrated ahigher level of resistance to all of the antimicrobialsexcept trimethoprim-sulfamethoxazole than E. colibacteria during the years 2011-2014. In our study, wefound increasing resistance trends of urinary pathogensfor cefixime (from 1% to 15%, p

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