Nesrin ÖCAL, Deniz DOĞAN, Ergun TOZKOPARAN, Orhan YÜCEL, Ali Fuat ÇİÇEK

Acute Eosinophilic Pneumonia with Respiratory Failure Induced by Synthetic Cannabinoid Inhalation

Background:In recent days, synthetic cannabinoid derivatives have become life threatening for young people. Here, we want to share a case of acute eosinophilic pneumonia triggered by inhalation of synthetic cannabinoid, new side effects of which are being detected day by day.Case Report:A 21-year-old male, who had no history of pulmonary diseases, was admitted to the clinic with shortness of breath. His oxygen saturation was measured as 85-86% in room air. Common irregular ground-glass opacities were observed in thorax radiology. His peripheral blood eosinophil count was 1100 cell/mm³ with a leukocyte differential of 12%. Sputum eosinophilia was also observed. The patient was diagnosed with acute eosinophilic pneumonia in terms of current clinical, radiological and laboratory findings. Rapid remission was achieved with corticosteroid therapy.Conclusion:This is the first reported case of acute eosinophilic pneumonia induced by synthetic cannabinoid inhalation.

PDF

___

King MA, Pope-Harman AL, Allen JN, Christoforidis GA, Christoforidis AJ. Acute eosinophilic pneumonia: radiologic and clinical features. Radiology 1997;203:715-9. [CrossRef]
Rom WN, Weiden M, Garcia R, Yie TA, Vathesatogkit P, Tse DB, et al. Acute eosinophilic pneumonia in a New York City firefighter exposed to World Trade Center dust. Am J Respir Crit Care Med 2002;166:797-800. [CrossRef]
Uchiyama N, Kawamura M, Kikura-Hanajiri R, Goda Y. A new class of designer drug and 12 synthetic cannabinoids detected in illegal products. Forensic Sci Int 2013;227:21-32. [CrossRef]
Forrester MB, Kleinschmidt K, Schwarz E, Young A. Synthetic cannabinoid exposures reported to Texas poison centers. J Ad- dict Dis 2011;30:351-8. [CrossRef]
Hermanns-Clausen M, Kneisel S, Szabo B, Auwärter V. Acute tox- icitydue to the confirmed consumption of synthetic cannabinoids: Clinical and laboratory findings. Addiction 2013;108:534-44. [CrossRef]
Wechsler ME. Pulmonary eosinophilic syndromes. Immunol Al- lergy Clin North Am 2007;27:477-92. [CrossRef]
Jhun BW, Kim SJ, Kim K, Lee JE. Clinical implications of ini- tial peripheral eosinophilia in acute eosinophilic pneumonia. Respirology 2014;19:1059-65. [CrossRef]
Hendrick DJ, Spicket GP. Eosinophilic pneumonia. In: Warrell DA, Cox TM, Firth JD, Benz EJ, editors. Oxford Textbook of Medicine. Oxford: Oxford University Press; 2003:1482-3.
Patterson C, Coleman M, editors. Revision Notes for the Re- spiratory Medicine Specialty Certificate Examination. Oxford: Oxford University Press; 2012:67-8.
Mahatma M, Haponik EF, Nelson S, Lopez A, Summer WR. Phenytoin-induced acute respiratory failure with pulmonary eo- sinophilia. Am J Med 1989;87:93-4. [CrossRef]