A Case of Angiolymphoid Hyperplasia with Eosinophilia Aggravated During Pregnancy

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon and benign vascular disorder characterized by angiomatous, pink-red papulonodular lesions mainly located on the scalp, neck, and periauricular region. Although the exact cause of ALHE is unknown, several etiologic factors including insect bites or parasites, trauma, hyperestrogen states, and immunologic factors have been implicated in the pathogenesis of the disease. Only a few cases of pregnancy related ALHE so far have been reported in the literature. In this article, we report a case of ALHE with postauricular location aggravated during the first trimester of pregnancy.

A Case of Angiolymphoid Hyperplasia with Eosinophilia Aggravated During Pregnancy

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon and benign vascular disorder characterized by angiomatous, pink-red papulonodular lesions mainly located on the scalp, neck, and periauricular region. Although the exact cause of ALHE is unknown, several etiologic factors including insect bites or parasites, trauma, hyperestrogen states, and immunologic factors have been implicated in the pathogenesis of the disease. Only a few cases of pregnancy related ALHE so far have been reported in the literature. In this article, we report a case of ALHE with postauricular location aggravated during the first trimester of pregnancy.

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  • 1. Olsen TG, Helwig EB. Angiolymphoid hyperplasia with eosinophilia. A clinicopathologic study of 116 patients. J Am Acad Dermatol 1985;12:781-96. [CrossRef]
  • 2. Zarrin-Khameh N, Spoden JE, Tran RM. Angiolymphoid hyperplasia with eosinophilia associated with pregnancy: a case report and review of the literature. Arch Pathol Lab Med 2005;129:1168-71.
  • 3. Hollo P, Marschalko M, Sikos G, Harsing J, Horvath A. Angiolymphoid hyperplasia with eosinophilia in pregnancy. J Eur Acad Dermatol Venereol 2005;19:645-6. [CrossRef]
  • 4. Moy RL, Luftman DB, Nguyen QH, Amenta JS. Estrogen receptors and the response to sex hormones in angiolymphoid hyperplasia with eosinophilia. Arch Dermatol 1992;128:825-8. [CrossRef]
  • 5. Wells GC, Whimster IW. Subcutaneous angiolymphoid hyperplasia with eosinophilia. Br J Dermatol 1969;81:1-14. [CrossRef]
  • 6. Akdeniz N, Kösem M, Calka O, Bilgili SG, Metin A, Gelincik I. Intralesional bleomycin for angiolymphoid hyperplasia. Arch Dermatol 2007;143:841-4. [CrossRef]
  • 7. Demir Y, Demir S, Aktepe F. Cutaneous lobular capillary hemangioma induced by pregnancy. J Cutan Pathol 2004;31:77-80. [CrossRef]
  • 8. Nichols GE, Gaffey MJ, Mills SE, Weiss LM. Lobular capillary hemangioma: an immunohistochemical study including steroid hormone receptor status. Am J Clin Pathol 1992;97:770-5.
Balkan Medical Journal-Cover
  • ISSN: 2146-3123
  • Başlangıç: 2015
  • Yayıncı: Erkan Mor
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