Madde Bağımlısı Anne Bebeklerinin Klinik ve Laboratuvar Özellikleri: Tek Merkez Deneyimi

Amaç: Gebelik döneminde alkol, yasadışı uyuşturucu ve psikoaktif madde kullanımının önemli ölçüde maternal, fetal ve neonatal morbiditelerle ilişkili olduğu bilinmektedir. Yasadışı madde kullanan anneden doğan bebeklerin özelliklerini araştırmayı planladık. Yöntem: Çalışmaya Eylül 2019 ve Aralık 2021 tarihleri arasında doğan yasadışı uyuşturucu madde kullanan anne bebekleri ve kontrol grubu olarak sağlıklı bebekler dahil edildi. Hastaların demografik, klinik ve laboratuvar verileri ile modifiye Finnegan skorları retrospektif olarak dosya verilerinden kaydedildi. Bulgular: Çalışmaya uyuşturucu madde kullanan anne bebeği 11 ve kontrol grubuna 13 sağlıklı bebek olmak üzere toplam 24 bebek dahil edildi. Madde kullanan annelerin yaşları, gebelik haftaları, doğum ağırlıkları, 1. ve 5. dakikada APGAR skorları sağlıklı bebeklerden istatistiksel olarak daha düşük bulundu. Modifiye Finnegan skoru ≥8 olup morfin ihtiyacı olan (n:4/11) hastalarda lökopeni ve nötropeni oranı morfin ihtiyacı olmayan (n:7/11) hastalara göre anlamlı olarak yüksek bulundu. Sonuç: Güncel sağlık problemi olarak yasadışı madde kullanımının önlenmesi, erken tespit ve izlemi konusunda politikaların geliştirilmesi ve neonatal yoksunluk sendromu açısından izlenen bebeklerin erken tespiti için yeni biomarkerların araştırılması konusunda detaylı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler:

Neonatal Yoksunluk Sendromu, Gebelik, Yenidoğan

Clinical and Laboratory Characteristics of Infants Born to Substance Addicted Mothers: A Single Center Experience

Objective: It is known that the use of alcohol, illicit drugs and psychoactive substances during pregnancy is significantly associated with maternal, fetal and neonatal morbidities. We planned to investigate the characteristics of babies born to mothers who use illicit substances. Method: Babies born to mothers using illicit drugs and healthy babies born between September 2019 and December 2021 were included in the study. Demographic, clinical and laboratory data of the patients and modified Finnegan scores were recorded retrospectively from the file data. Results: A total of 24 infants, 11 infants of drug-using mothers and 13 healthy infants in the control group, were included in the study. Ages of mothers, gestational weeks, birth weights, and APGAR scores at 1st and 5th minutes of babies born to mothers who used substance were found to be statistically lower than healthy babies. The rates of leukopenia and neutropenia were found to be significantly higher in patients with a modified Finnegan score ≥8 and in need of morphine (n:4/11) compared to patients without morphine need (n:7/11). Conclusion: There is a need for detailed studies on the prevention of illicit substance use as a current health problem, the development of policies on early detection and follow-up, and the search for new biomarkers for the early detection of infants followed for neonatal withdrawal syndrome.

Keywords:

neonatal abstinence syndrome, pregnancy, newborn,

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