Siklobütan Halkası İçeren Schiff Bazı ve Metal Komplekslerinin Sentezi ve Antimikrobiyal Aktivite Çalışmaları

Siklobütan türevleri bir çok alanda kullanılmaktadır. Özellikle tıp alanında bir kısım hastalıklara karşı ilaçların üretimi bunlarınbaşında gelmektedir. 3-sübstitüe siklobütan karboksilik asit türevleri antiinflamator ve antidepresant aktiviteler göstermektedir. Schiffbazları analitik kimyada olduğu kadar boyar maddelerin üretiminde, bazı ilaçların hazırlanmasında, elektronik endüstrisinde, plastiksanayiinde ve sıvı kristal teknolojisi gibi çeşitli dallarda gittikçe artan öneme sahip maddelerdir. Bu çalışmada yapısında siklobütangrubu bulunan tiyosemikarbazon türevi Schiff bazı ve bunun nikel, bakır ve çinko kompleksleri sentezlenmiştir. Sentezlenenbileşiklerin saflaştırılması kristallendirme ve kolon kromatografisi ile yapılmıştır. Karakterizasyon işlemlerinde ise IR, ${}^{1}H$ NMR, ${}^{13}C$NMR ve elementel analiz gibi enstrümental analiz yöntemleri kullanılmıştır. Sentezlenen komplekslerin mononükleer olduğu ve $ML_2$yapısında olduğu bulunmuştur. Ayrıca, sentezlenen bileşiklerin farklı mikroorganizmalara karşı antimikrobiyal etkileri araştırılmıştır.

Synthesis and Antimicrobial Activity Studies of Cyclobutane Ring Containing Schiff Base and their Metal Complexes

Cyclobutane derivatives are used in many fields. Particularly in the field of medicine, the production of some anti-disease drugs is one of them. The 3-substituted cyclobutane carboxylic acid derivatives exhibit anti-inflammatory and antidepressant activities. Schiff bases are increasingly important in analytical chemistry as well as in the production of dyes, preparation of certain drugs, electronics industry, plastics industry and various branches such as liquid crystal technology. In this study, thiosemicarbazone derivative Schiff base containing cyclobutane group and their Cu(II), Ni(II) ve Zn(II) complexes were synthesised and characterized. Purification of the synthesised compounds were carried out with crystallography and column cromatography techniques. In the characterization of the Schiff base and their complexes, IR,${}^{1}H$ NMR, ${}^{13}C$ NMR spectral techniques and elemental analysis were used. All the complexes were found to be mononuclear and $ML_2$ form. Besides, antimicrobial activities of the Schiff base and its transition metal complexes have been tested different microorganisms.

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