Microwave-Assisted Synthesis of Some Benzimidazole Derivatives Containing Imine Function

Benzimidazol modern ilaç keşfinde önemli bir farmakofordur. Birçok benzimidazole türevi yeni ilaç adayı bileşikler elde etmek amacıyla organik kimyacılar tarafından sentezlenmektedir. Bu çalışmada, imin fonksiyonu içeren yedi yeni benzimidazol türevi bileşik mikrodalga ışıma ve geleneksel yöntemle sentezlenmiştir. Elde edilen sonuçlara göre mikrodalga ısıtmanın geleneksel ısıtmaya göre verim, üründeki saflık ve zaman yönünde avantajları olduğu görülmüştür.

İmin Fonksiyonu İçeren BazıBenzimidazol Türevlerinin Mikrodalga Destekli Sentezi

Benzimidazole is an important pharmacophore in modern drug discovery. Many benzimidazole derivatives have been synthesized by organic chemists to obtain new drug candidates. In this work, seven new benzimidazole derivatives containing imine function have been synthesized by using microwave irradiation and conventional heating procedure. The results showed that microwave heating has many advantages on classical heating procedure on yields, purity of product and reduced times.

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