Noorulain AKRAM, Zainab SHAHZOR, Iram MUSHTAQ, Ayesha ISHTİAQ, Khadam HUSSAİN, Iram MURTAZA

Küresel hastalık tezgahından başucu araştırmasına yönelik moleküler teknolojideki mikroRNA'lar

MikroRNA'lar, kodlamayan RNA düzensizliklerinin bir kategorisi, kanser, diyabet, kalp hastalıkları, immünolojik bozukluklar, nörolojik hastalıklar ve birçok metabolik hastalık dahil olmak üzere çok sayıda patolojik durumda yer alır. MikroRNA uygulamaları bilgisindeki ilerleme, bazı erken hastalık belirteçlerinin teşhisine yol açtı. Halihazırda yenilikçi moleküler biyoteknoloji, yaşamı tehdit eden hastalıklarla mücadele için mikroRNA susturucuları ve inhibitörleri, ikame ediciler ve aşırı ifade edicilerin uygulanması alanında gelecek vaat ediyor. Kanser alanındaki mega hasta gruplarının RNA dizi kütüphaneleri, çoklu mikroRNA'ların ekspresyon profilini içerir, ancak diğer hastalıklarda da bu tür mikroRNA kütüphanelerini geliştirmek için zamana ihtiyaç vardır. Gelecekte bilim adamlarının basit biyoinformatik analizi ile çoklu klinik senaryolarda mikroRNA uygulamalarının perspektifini yargılamasını kolaylaştıracaktır.

Anahtar Kelimeler:

mikroRNA, teşhis belirteçleri, uygulamalar.

MicroRNAs in molecular technology to address global diseases bench to bedside research

MicroRNAs a category of noncoding RNA dysregulations are involved in numerous pathological conditions including cancer, diabetes, heart diseases, immunological disorders, neurological diseases and many metabolic diseases. Advancement in the knowledge of microRNA applications led to the diagnosis of some early markers of diseases. Currently innovative molecular biotechnology is holding promising future in the field of application of microRNA silencers and inhibitors, replacers and over expressers for tackling life threatening diseases. RNA seq libraries of mega patients groups in the field of cancer include the expression profile of multiple microRNAs but there is need of time to develop such libraries of miRNAs in other diseases too. It will facilitate scientist in future to judge the perspective of microRNA applications in multiple clinical scenarios by simple bioinformatics analysis.

Keywords:

microRNAs, diagnostic markers, applications,

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