In this study, it was aimed to isolate the bacteria from sheep with pneumonia in Burdur and Isparta province and to determine of the antibiotic sensitivity. By the aim, a total of 160 lung samples from sheep with pneumonia was collected from Burdur and Isparta province. A total of 68 bacterial agents was isolated from the 42 (25.33 %) of 160 sheep lung. Isolated microorganisms were identified as follows: 15 (22.06%) were Pasteurella spp and Staphylococcus aureus, 11 (16.18%) Candida spp., 10 (14.71%) Klebsiella pneumonia, 9 (13:24%) E. coli, 3(4.41%) Streptococcus spp. and Corynebacterium spp. and 2 (2.94%) Enteroba cter spp. Antibaclerial susceptibility of microorganisms to various antibiotics were tested by Kirby-Bauer disc diffussion methods. Staphylococcus aureus isolates were determined to sensitive 100% oxytetracycl ine and amoxicillin/klavulanic acid, 93.33% ampicillin, amoxycillin and danofloxacin. Pasteurella spp. strains 100% oxytetracycline, amoxicillinlklavulanic acid, ampicillin. amoxicillin and neomyCı 93.33% danofloxacin, and Klebsiella pneumonia 100% oxytetracycline, amoxicillin, neomycin, gentamicin, sulphamethaksazoleltrimethoprime, cefaperazone, 90% amoxicillin klavulanic acid, ampicillin and danofloxacin.