Ahmet EVLİCE, Turgay DEMİR, Filiz KOÇ

Myastenia Gravis ve Gebelik

Myastenia gravis, dünyada yaklaşık bir milyon kişiyi etkileyen otoimmun bir hastalıktır. Nikotinik asetilkolin reseptörüne veya diğer postsinaptik antijenlere (kas spesifik kinaz gibi) karşı gelişen antikorlar sonucunda myastenia gravis gelişir. Timusun hiperplazisi ve tümörü bu anormal antikorlaın yapımına neden olur. Myastenia gravis tanısı yorgunluk, ağrısız kas güçsüzlüğü gibi kardinal belirtilere eşlik eden serum otoantikor pozitifliği, elektromyografi de nöromüsküler iletim kusurunun gözlenmesi ile konulur. Semptomatik tedavi antikolinesterazlarla, hastalığın kontrolü ise immun aracılı tedavilerle yöntemleriyle yapılır. Myastenia gravisin kadınlarda fertilite üzerine etkisi yoktur, olgular çocuk sahibi olabilirler. Bu yazıda gebelerde myastenia gravise yaklaşım detaylı olarak ele alınacaktır

Archives Medical Review Journal

Myasthenia gravis is an autoimmune disease affecting nearly one million individuals worldwide. Myasthenia gravis develops due to antibodies against the nicotinic acetylcholine receptoror othe r postsynaptic antigens. Hyperplasia and tumours of the thymus can cause the abnormal production of these autoantibodies. Diagnosis of myasthenia gravis could be made through recognition of the cardinal clinical features of fatigable, painless muscle weakness with confirmatory serum autoantibody analysis and electromyographic evidence of disordered neuromuscular transmission, thereby excluding other differential diagnoses. Symptomatic improvement may be achieved through the use of anticholinesterase drugs, although usually immune-directed treatments are required to control the disease. The disease does not affect fertility in women and patients can have children. In this paper management to pregnant myasthenia gravis patients will be discussed in detail

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