Pınar Yılgör HURİ, Nesrin HASIRCI, Vasıf HASIRCI

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Kemik Doku Mühendisliği

Kemik dokusu zedelendiği veya kayba uğradığında, hasarlı bölgenin tamir edilmesinde ya da tamamen yenilenmesinde kullanılmak amacıyla laboratuvarda yapay kemik dokusu üretebilmek günümüzün önemli tıbbi ve sosyal ihtiyaçlarından birisidir. Kemik doku mühendisliği, yapay kemik üretimi için günümüzün en önemli seçeneklerden biri olarak görülmektedir. Bu yöntemde temel yaklaşım, amaca uygun bir kaynaktan izole edilen hücreler ile biyobozunur polimerik doku desteklerinin birlikte kullanılmasıyla laboratuvar ortamında üç boyutlu canlı kemik dokusunun oluşturulmasıdır. Vücut içerisinde hücre aktivitelerinin düzenleyicisi olan büyüme faktörlerinin polimerik yapıya katılması ise, hem kırılgan moleküller olan büyüme faktörlerini bozunmadan koruyacak hem de defekt bölgesinde lokalize edecek ve zamana bağlı bir şekilde ortama sağlanmalarını gerçekleştirecektir. Dolayısıyla, kemik doku mühendisliği uygulamalarında doku desteği yapı içerisine biyolojik olarak etkin biyoaktif moleküllerin eklenmesi büyük önem kazanmış ve çalışmalar bu yönde ilerlemeye başlamıştır. Bu makalede doku mühendisliği yöntemiyle fonksiyonel yapay kemik dokusu oluşturulması konusundaki son gelişmeler ele alınmıştır.
Anahtar Kelimeler:

Doku Mühendisliği, Kemik, Mezenkimal Kök Hücre, Kontrollü Salım, Büyüme Faktörü

Bone Tissue Engineering

The requirement for new bone to replace or restore the function of damaged or lost bone is a major clinical and social need. Bone tissue engineering has been considered as the alternative strategy to produce artificial bone grafts. The strategy of the method is to combine progenitor or mature cells isolated from desired cell source with biodegradable scaffolds to produce 3-D viable artificial bone in the laboratory conditions. Incorporation of growth factors that are regulators of cellular activities in vivo into the construct would protect these fragile molecules from degradation while sustaining their local concentration over a given period of time at the target site. Therefore, activities have been concentrated on the development of multi functional tissue engineering scaffolds capable of delivering the required bioactive agents to initiate and control cellular activities. This article reviews the recent developments in the production of functional artificial bone constructs via tissue engineering technique.
Keywords:

Tissue Engineering, Bone, Mesenchymal Stem Cell, Controlled Release, Growth Factor,

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Arşiv Kaynak Tarama Dergisi-Cover
  • ISSN: 1300-3755
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1992
  • Yayıncı: Çukurova Üniversitesi Tıp Fakültesi
Arşiv
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