Arzu TAY, Yusuf TAMAM

3717

İnmede Myeloperoksidazın Rolü

İskemik inme, beyin dokusunda meydana gelen infarkt nedeni ile ani olarak ortaya çıkan patolojik bir durumdur. İskemik inmenin en önemli nedeni aterosklerozdur. Gelişmiş ülkelerdeki en sık ölüm nedeni aterosklerozdur. Aterosklerozun kronik bir inflamatuar hastalık olduğu düşünülmektedir. İnflamasyon süreciyle iskemik olaylar arasında ilişki vardır. Oksidatif stres ve inflamasyon, aterosklerozun patogenezine katkıda bulunur. Miyeloperoksidaz enzimi, oksidatif strese yanıt olarak lökositlerden salgılanan lizozomal bir enzimdir. Lökositlerde bolca bulunan ve reaktif oksidan ürünler oluşturan miyeloperoksidaz enzimi aterosklerotik reaksiyonlarda bulunur ve katalitik aktivite gösterir.
Anahtar Kelimeler:

Akut iskemik inme, miyeloperoksidaz, ateroskleroz, inflamasyon, oksidatif stres

Role of Myeloperoxidase in Stroke

Ischemic stroke is a significant pathological state which results from sudden infract in brain tissue. Most common cause of ischemic stroke is atherosclerosis. It is the most common cause of mortality in developed countries. Atherosclerosis has been purposed to be a chronic inflammatory disease. There is significant association between inflammatory process and ischemic events. Oxidative stress and inflammation significantly contribute to development of atherosclerosis. Myeloperoxidase enzyme is a lysosomal enzyme secreted from leucocytes as a response to oxidative stress. MPO which has been abundantly present in leucocytes, forms reactive oxidant products and plays role in atherosclerotic reactions thorough its catalytic activity.
Keywords:

ischemic stroke, myeloperoxidase, atherosclerosis, inflammation, oxidative stress,

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Arşiv Kaynak Tarama Dergisi-Cover
  • ISSN: 1300-3755
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1992
  • Yayıncı: Çukurova Üniversitesi Tıp Fakültesi
Arşiv
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İnmede Myeloperoksidazın Rolü

Arzu TAY, Yusuf TAMAM