Hematolojik ve biyokimyasal parametreler ile WOMAC indeksinin osteoartrit şiddeti ile olan ilişkisi: Retrospektif bir çalışma
Amaç: Amacımız, Western Ontario ve McMaster Üniversiteleri Osteoartrit skoru (WOMAC) ile birlikte kolayca saptanabilecek tam kanda herhangi bir hematolojik değişikliğin diz osteoartriti şiddetini öngörmede tanısal değere sahip olup olmadığını araştırmaktır. Yöntemler: 208 diz osteoartrit hastasını (112 hasta erken ve 106 hasta geç osteoartrit) içeren retrospektif bir çalışma planlandı. Yaş, CRP, nötrofil lökosit oranı ve WOMAC index için cut-off değerleri hesaplandı. Geç osteoartrit için bağımsız faktörlerini tanımlamak için çok değişkenli lojistik regresyon modeli kullanıldı. Bulgular: Erken ve geç osteoartrit karşılaştırıldığında, C-reaktif protein, nötrofil lökost oranı ve WOMAC indeksi anlamlı olarak geç osteoartrit olan grupta daha yüksekti (sırası ile; p=0,019, p=0,028 ve p=0,001). Yaş, C-reaktif protein, nötrofil lökosit oranı ve WOMAC index Area Under Curve değerleri sırasıyla 0,922, 0,533, 0,558 ve 0,824 olarak bulundu. Geç osteoartrit ile ilişkili bağımsız risk faktörlerini belirlemek amacı ile yapılan regresyon analizinde, nötrofil lökosit oranı için odds oranı 1.317 (95% CI = 1.030-1.682, p=0.034 ), C-reaktif protein için odds oranı 1.055 (95% CI = 1.004-1.108, p= 0.028) ve WOMAC index için odds oranı 1.078 (95% CI = 1.056-1.100, p=0.001) idi. Geç osteoartrit öngörüsünde yaş, nötrofil lökosit oranı, C-reaktif protein and WOMAC index istatistiksel olarak anlamlı idi. Sonuç: Nötrofil lökosit oranı, C-reaktif protein düzeyleri ve WOMAC indeksinin, geç osteoartrit için bağımsız risk faktörleri ile ilişkili olduğu düşünülmektedir.
Relationship of hematological and biochemical parameters with WOMAC index to severity of osteoarthritis: A retrospective study
Aim: Our aim was to investigate whether any hematologic changes that could be detected easily in whole bloodcounts together with the Western Ontario and McMaster Universities Osteoarthritis score (WOMAC) haddiagnostic value for predicting knee osteoarthritis severity.Methods: A retrospective study including a total of 208 knee osteoarthritis patients (112 patients early and 106patients late osteoarthritis) was carried out. Cut-off values for age, C-reactive protein, neutrophil leukocyte ratioand WOMAC index for osteoarthritis were calculated. A multivariate logistic regression model was used toidentify the independent factors of late osteoarthritis.Results: Compared with late osteoarthritis with early osteoarthritis, late osteoarthritis had significantly higherC-reactive protein, neutrophil leukocyte ratio and WOMAC index (p=0.019, p=0.028 and p=0.001,respectively). Area Under Curve was found to be 0.922, 0.533, 0.558 and 0.824 for age, C-reactive protein,neutrophil leukocyte ratio and WOMAC index, respectively. Multilogistic regression analysis was performedwith C-reactive protein, neutrophil leukocyte ratio and WOMAC index to determine independent risk factorsassociated with late osteoarthritis. Odds ratios for neutrophil lymphocyte ratio, C-reactive protein and WOMACindex were found to be 1.317 (95% CI = 1.030-1.682, p = 0.034), 1.055 (95% CI = 1.004-1.108, p = 0.028) and1.078 (95% CI = 1.056-1.100, p=0.001), respectively. Age, neutrophil leukocyte ratio, C-reactive protein andWOMAC index were statistically significant in predicting late osteoarthritis.Conclusions: Our study suggests that increased neutrophil leukocyte ratio, C-reactive protein and WOMACindex are associated with independent risk factors for late osteoarthritis
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