ELİF TURAN, Hafize KIZILKAYA, Yalçın ARAL

Metabolik sendrom postmenopozal osteoporoz ile ilişkili midir? Retrospektif bir çalışma

Amaç: Postmenopozal kadınlarda, osteoporoz ile metabolik sendrom arasındaki ilişkiyi değerlendirmek.Yöntemler: 65 yaşın altında toplam 98 postmenopozal kadın çalışmaya dahil edildi. Kemik mineral dansitometre sonucuna göre; lumber ve/veya femur boyun T skoru>-2.5 olan 49 hasta postmenopozal osteoporoz olmayan gruba (Grup 1), T skoru≤-2.5 olan 49 hasta postmenopozal osteoporoz grubuna (Grup 2) dahil edildi. Tüm demografik verileri içeren hasta profili, antropometrik değerlendirme ve tıbbi öykü kaydedildi. Serum açlık glukozu, lipit profili ve serum 25 OH D vitamin seviyesi de kaydedildi.Bulgular: Grup 1 ve Grup 2 karşılaştırıldığında; yaş (p=0.001), menopoz yaşı (p=0.003) sistolik kan basıncı (p=0.004) ve diyastolik kan basıncı (p=0.001) Grup 2’de Grup 1’e göre anlamlı şekilde daha yüksekti. Vücut kitle indeksi, boy, kilo, lipid profili, serum 25 OH vitamin D düzeyleri açısından gruplar arasında anlamlı fark yoktu (p>0.05). Osteoporozu olan 49 hastanın 36’sında (%73), osteoporozu olmayan 49 hastanın ise 25’inde (%51) metabolik sendrom tespit edildi. Osteoporoz ile metabolik sendrom arasında istatistiksel olarak anlamlı ilişki tespit edildi (p=0,037). Sonuç: Postmenopozal kadınlarda osteoporoz ile metabolik sendrom arasında anlamlı ilişki olduğu tespit edilmiştir.

Anahtar Kelimeler:

Metabolik sendrom, menopoz, osteoporoz

Is metabolic syndrome related to postmenopausal osteoporosis? A retrospective study

Aim: To evaluate the difference between postmenopausal women with and without osteoporosis in terms of metabolic syndrome.Methods: A total of 98 postmenopausal women younger than 65 years, were enrolled in the study. According to the bone mineral density examination; 49 participants who had T-score>−2.5 at the spine or/and femoral neck were included in the group without osteoporosis (Group 1), and 49 participants who had T-score≤−2.5 at the spine or/and femoral neck were included in the osteoporosis group (Group 2). Patient’s profile which included all demographic data, particularly anthropometric evaluation and medical history was obtained. Serum fasting glucose, lipid profiles and 25 OH vitamin D levels were also recorded. Results: Age (p=0.001), menopausal age (p=0.003), systolic blood pressure (p=0.004) and diastolic blood pressure (p=0.001) of Group 2 were significantly higher than Group 1. There were no significant difference in terms of body mass index, weight, lipid profiles, serum calcium and serum 25 OH vitamin D levels among the groups (p>0.05 for all). Twenty five (51%) of 49 women in Group 1 and 36 (73%) of 49 women in Group 2 had metabolic syndrome. There was a statistically significant relationship between osteoporosis and the metabolic syndrome (p=0.037). Conclusion: Our results demonstrated that osteoporosis is related with the metabolic syndrome in postmenopausal women.

Keywords:

metabolic syndrome, osteoporosis, menopause,

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