The role of Diffusion-weighted magnetic resonanceimaging and apparent diffusion coefficient (ADC) values inthe evaluation of solid breast lesions

Aim: To investigate the role of Diffusion-weighted magnetic resonance imaging and apparent diffusion coefficient (ADC) values inthe differential diagnosis of solid lesions of the breast.Materials and Methods: Diffusion-weighted images and ADC values from 36 women with 37 solid lesions definitely diagnosedthrough breast biopsy and post-surgical histopathology were evaluated retrospectively. ADC values obtained from malignant andbenign solid lesions of the breast were compared using the t-test. The optimum threshold value for use in differentiating benign andmalignant lesions was determined using ROC analysis, and sensitivity and specificity values were calculated. Results: Histological analysis identified 23 lesions and 14 benign lesions. Mean age (49 ± 7.8 years) was higher in the group withmalignant breast lesions than in the group with benign breast lesions (37.3 ± 8.2) (p

PDF

___

1. T.C. Sağlık Bakanlığı TÜRKİYE KANSER İSTATİSTİKLERİ 2015. https://hsgm.saglik.gov.tr/ depo/birimler/kanser-db/istatistik/Turkiye_Kanser_ Istatistikleri_2015.pdf access date 30.01.2018
2. Smith RA, Saslow D, Sawyer KA, et al. American Cancer Society Guidelines for Breast Cancer Screening: Update 2003. CA Cancer J Clin 2003;53:141-69.
3. Onishi M, Furukawa A, Takahashi M, et al. Wide variety of dynamic contrast- enhanced MR appearances of breast cancer: pathologic correlation study. Eur J Radiol 2008;65:286-92.
4. Hatakenaka M, Soeda H, Yabuuchi H, et al. Apparent diffusion coefficients of breast tumors: clinical application. Magn Reson Med Sci 2008;7:23-9.
5. Woodhams R, Matsunaga K, Kan S, et al. ADC mapping of benign and malignant breast tumors. Magn Reson Med Sci 2005;4:35-42.
6. Rubesova E, Grell AS, De Maertelaer V, et al. Quantitative diffusion imaging in breast cancer: a clinical prospective study. J Magn Reson Imaging 2006;24:319-24.
7. Kinoshita T, Yashiro N, Ihara N, et al. DiffusionWeighted Half-Fourier Single- Shot Turbo Spin Echo Imaging in Breast Tumors: Differentiation of Invasive Ductal Carcinoma from Fibroadenoma. J Comput Assist Tomogr 2002;26:1042-6.
8. Park MJ, Cha ES, Kang BJ, et al. The role of diffusionweighted imaging and the apparent diffusion coefficient (ADC) values for breast tumors. Korean J Radiol 2007;8:390-6.
9. Marini C, Iacconi C, Giannelli M, et al. Quantitative diffusion-weighted MR imaging in the differential diagnosis of breast lesion. Eur Radiol 2007;17:2646- 55.
10. Yabuuchi H, Matsuo Y, Okafuji T, et al. Enhanced mass on contrast-enhanced breast MR imaging: Lesion characterization using combination of dynamic contrast-enhanced and diffusion-weighted MR images. J Magn Reson Imaging 2008;28:1157-65.
11. Lo GG, Ai V, Chan JK, et al. Diffusion-weighted magnetic resonance imaging of breast lesions: first experiences at 3T. J Comput Assist Tomogr 2009;33:63-9.
12. Lee CH. Problem Solving MR imaging of the breast Radiol Clin North Am 2004;42:919-34.
13. Heywang-Kobrunner SH, Viehweg P, Heinig A, et al. Contrast-enhanced MRI of the breast: accuracy, value, controversies, solutions. Eur J Radiol 1997;24:94- 108.
14. Kuhl CK, Mielcareck P, Klaschik S, et al. Dynamic breast MR imaging: is signal intensity time course data useful for differential diagnosis of enhancing lesions? Radiology 1999;211:101-10.
15. El Khouli RH, Macura KJ, Jacobs MA, et al. Dynamic contrast-enhanced MRI of the breast: quan-titative method for kinetic curve type assessment. AJR Am J Roentgenol 2009;193: 295-300.
16. Bozkurt Bostan T, Koç G, Sezgin G, et al. Value of Apparent Diffusion Coefficient Values in Differentiating Malignant and Benign Breast Lesions. Balkan Med J 2016;33:294-300.
17. Partridge SC, De Martini WB, Kurland BF, et al. Quantitative diffusion-weighted imaging as an adjunct to conventional breast MRI for improved positive predictive value. AJR Am J Roentgenol 2009;193: 1716-22.
18. Kuroki Y, Nasu K, Kuroki S, et al. Diffusion-weighted imaging of breast cancer with the sensitivity encoding technique: analysis of the apparent diffusion coefficient value. Magn Reson Med Sci 2004;3:79-85.
19. Tezcan S, Ulu Ozturk F, Uslu N, et al. The Role of Combined Diffusion-Weighted Imaging and Dynamic Contrast-Enhanced MRI for Differentiating Malignant from Benign Breast Lesions Presenting Washout Curve. Can Assoc Radiol J 2020.