The role of Crocin in an acrylamide-induced neurotoxicity model in Wistar rats

The role of Crocin in an acrylamide-induced neurotoxicity model in Wistar rats

Aim: The changes in rat brain tissues treated with Crocin (Cr) as a protective agent in an acrylamide (AA) neurotoxicity model wereinvestigated.Material and Methods: The present with of the experimental animal ethics committee at Inonu University, Faculty of Medicine (2016/ A-59). Forty male rats were randomly divided into 4 groups with study was conducted the approval equal number of rats (10):Control, Cr, AA, Cr + AA Groups. Malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant status (TAS), total oxidantstatus (TOS), Oxidative stress index (OSI), superoxide dismutase (SOD), catalase (CAT) and protein values were examined in thebrain tissues.Results: MDA, TOS and OSI levels increased in brain tissues of AA administered rats when compared to the other groups, whilethe GSH, TAS, SOD and CAT levels decreased in the group (p < 0.05). GSH, TAS, SOD and CAT levels increased, but MDA, TOS andOSI levels decreased in the AA + Cr administered group when compared to the AA group (p < 0.05). It was observed that oral AAadministration altered the antioxidant/oxidant balance favoring the oxidants in male rat brain tissues, leading to oxidative stressinduced neurotoxicity, while Cr administration reestablished the normal antioxidant/oxidant balance, preventing the oxidative stressinduced neurotoxicity via detoxification.Conclusion: The present study concluded that the administered Cr dose was sufficient to prevent neurotoxicity and we recommendthat adequate amounts of Cr should be consumed to prevent AA-induced toxicity and improve antioxidant capacity.

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Annals of Medical Research-Cover
  • Yayın Aralığı: 12
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

Evaluation of work-related musculoskeletal disorders and ergonomic risk levels among instrumentalist musicians

Filiz ÖZDEMİR, Nisanur TUTUŞ, Şakir Orçun AKGÜN, Melek Havva KILÇIK

Lumbosacral alignment in lumbar disc herniation

Tuba Tülay KOCA, Ejder BERK, Burhan Fatih KOÇYİĞİT, Vedat NANCİTARHAN

The role of Crocin in an acrylamide-induced neurotoxicity model in Wistar rats

Mehmet Erman ERDEMLİ, Harika Gözde GÖZÜKARA BAĞ, Zeynep ERDEMLİ, Eyüp ALTINÖZ

Comparison of the effects of supreme laryngeal mask airway and endotracheal tube on airway reflexes in patients who underwent nasal surgery: A randomized, controlled clinical trial

Erol KARAASLAN

The incidence of artifacts in cone beam computed tomography images: A pilot study

Gulsun AKAY, Muhsin Sait KARATAŞ, Özge KARADAĞ, Özlem ÜÇOK, Kahraman GÜNGÖR

The comparison of readability between information texts from web sites of private clinics and private hospitals

İhsan KUZUCU

Sociodemographic characteristics and dynamic thiol/ disulfide homeostasis in pediatric patients presenting with scorpion sting

Serhat DEVECİ, Mahmut DEMİR, Ahmet GÜZELÇİÇEK, Adnan KİRMİT

The relationship between footwear fit and foot deformities, musculoskeletal disorders and physical activity level

Gül Öznur KARABIÇAK

The duration of sleep in adolescent student in Denpasar

I Putu Eka WIDYADHARMA, I Gusti Agung Gede Ari SWANDA, Rindha Dwi SIHANTO, Desak Ketut Indrasari UTAMI

Evaluation and cost analysis of the patients, who applied to the emergency service with an open injury of hand and / or wrist

Hakan HAKKOYMAZ, Duran TOPAK, Halit BAYKAN, Ali İhsan KILCI, Özlem GÜLER, Ramazan AZİM