Ali DOGAN

The relationship between residual SYNTAX score and neutrophil/lymphocyte ratio in ST segment elevation myocardial infarction patients

Aim: The objective of this study was to research the relation between residual SYNTAX score and neutrophil/lymphocyte ratio in patients with ST segment elevation myocardial infarction (STEMI).Material and Methods: A total of 300 patients with STEMI were included from January 2015 to February 2020. Residual SYNTAX score (RSS) was calculated for each patient after primary percutaneous coronary intervention (PCI). RSS>8 was accepted as high RSS. Clinical and laboratory features of the patients including neutrophil/lymphocyte ratio were recorded.Results: 109 (36.3%) of the patients had RSS over 8 and classified as high RSS. In the high residual SYNTAX group, while the neutrophil count was higher (p

PDF

___

1. Neumann FJ, Sousa-Uva M, Ahlsson A, et al. 2018 ESC/ EACTS Guidelines on myocardial revascularization. EuroIntervention 2019;14:1435-534.
2. Braga CG, Cid-Alvarez AB, Diéguez AR, et al. Prognostic impact of residual SYNTAX score in patients with ST elevation myocardial infarction and multivessel disease: Analysis of an 8-year all-comers registry. Int J Cardiol 2017;243:21-6.
3. Loutfi M, Ayad S, Sobhy M. Impact of the Residual SYNTAX Score on Outcomes of Revascularization in Patients with ST-Segment ElevationMyocardial Infarction and Multivessel Disease. Clin Med Insights Cardiol 2016;10:29-35.
4. Sianos G, Morel MA, Kappetein AP, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention 2005;1: 219-27.
5. Farooq V, Serruys PW, Bourantas CV, et al. Quantification of incomplete revascularization and its association with five-year mortality in the synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) trial validation of the residual SYNTAX score. Circulation 2013;128:141- 51.
6. Généreux P, Palmerini T, Caixeta A, et al. Quantification and impact of untreated coronary artery disease after percutaneous coronary intervention: the residual SYNTAX (Synergy Between PCI with Taxus and Cardiac Surgery) score. J Am Coll Cardiol 2012;59:2165-74.
7. Núñez J, Núñez E, Bodí V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting longterm mortality in ST segment elevation myocardial infarction. Am J Cardiol 2008;101:747-52.
8. Papa A, Emdin M, Passino C, et al. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clin Chim Acta 2008;395:27-31.
9. Tanindi A, Erkan AF, Ekici B, et al. Neutrophil to lymphocyte ratio is associated with more extensive, severe and complex coronary artery disease and impaired myocardial perfusion. Turk Kardiyol Dern Ars. 2014 Mar;42:125-30.
10. Gecmen C, Babur Guler G, Erdogan E, et al. SYNTAX score predicts postoperative atrial fibrillation in patients undergoing on-pump isolated coronary artery bypass grafting surgery. Anatol J Cardiol 2016;16:655-61.
11. Magro M, Nauta S, Simsek C, et al. Value of the SYNTAX score in patients treated by primary percutaneous coronary intervention for acute STelevation myocardial infarction: the MI SYNTAX score study. Am Heart J 2011;161:771-81.
12. Gao G, Feng L, Zhang D, et al. Proximal left anterior descending coronary artery stenosis should be considered when using the prognostic value of the residual SYNTAX score: Data from 10343 consecutive patients with long-term follow up in the real world. Catheter Cardiovasc Interv 2018;91:639-45.
13. Kurtul S, Sarli B, Baktir AO, et al. Neutrophil to lymphocyte ratio predicts SYNTAX score in patients with non-ST segment elevation myocardial infarction. Int Heart J 2015;56:18-2.
14. Alfakry H, Sinisalo J, Paju S, et al. The association of serum neutrophil markers and acute coronary syndrome. Scand J Immunol 2012;76:181-7.
15. Shen XH, Chen Q, Shi Y, et al. Association of neutrophil/ lymphocyte ratio with long-term mortality after ST elevation myocardial infarction treated with primary percutaneous coronary intervention. Chin Med J 2010;123:3438-43.
16. Chen C, Cong BL, Wang M, et al. Neutrophil to lymphocyte ratio as a predictor of myocardial damage and cardiac dysfunction in acute coronary syndrome patients. Integr Med Res. 2018;7:192-9.
17. Capodanno D, Chisari A, Giacoppo D, et al. Objectifying the impact of incomplete revascularization by repeat angiographic risk assessment with the residual SYNTAX score after left main coronary artery percutaneous coronary intervention. Catheter Cardiovasc Interv 2013;1:333-40.
18. Wald DS, Morris JK, Wald NJ, et al; PRAMI Investigators. Randomized trial of preventive angioplasty in myocardial infarction. N Engl J Med 2013;369:1115-23.
19. Gershlick AH, Khan JN, Kelly DJ, et al. Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease: The CvLPRIT trial. J Am Coll Cardiol 2015;65:963-72.
20. Engstrom T, Kelbaek H, Helqvist S, et al, DANAMI PRIMULTI Investigators. Complete revascularisation versus treatment of the culprit lesion only in patients with ST-segment elevation myocardial infarction and multivessel disease (DANAMI-3-PRIMULTI): An open-label, randomised controlled trial. Lancet 2015;386:665-71.
21. Smits PC, Abdel-Wahab M, Neumann FJ, et al. Compare-Acute Investigators. Fractional flow reserve-guided multivessel angioplasty in myocardial infarction. N Engl J Med 2017;376:1234-44.
22. Angkananard T, Anothaisintawee T, McEvoy M, et al. Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and MetaAnalysis. Biomed Res Int 2018 ;2018:2703518.
23. Danesh J, Collins R, Appleby P, et al. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA. 1998;279:1477-82.
24. Rosner GF, Kirtane AJ, Genereux P, et al. Impact of the Presence and Extent of Incomplete Angiographic Revascularization After Percutaneous Coronary Intervention in Acute Coronary Syndromes: The Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY). Circulation 2012;125:2613-20.