The relationship between asthma and eating disorders

Obesity is a common comorbidity in asthma and obesity not only causes asthma development, but also leads to weaker asthmacontrol and higher asthma severity. The relationship between obesity and asthma is similar to the relationship between chicken andegg. Obesity can be confusing in the diagnosis and management of asthma. Obesity in asthmatic patients causes overdiagnosis,misdiagnosis, or less diagnosis. The association of asthma and obesity has increased especially due to western type nutritionand sedentary lifestyle. Patients with obesity and asthma as a result of increased inflammatory mediators bronchoconstruction,adversely affected by lung mechanics, increased alveolar-arterial gradient, ventilation-perfusion imbalance, decreased lung volume,asthma disease and other comorbid conditions such as increased comorbid conditions, such as more frequent causes of dyspnea.They are very symptomatic, presenting more in these patients and the quality of life of these patients is worse. Another problemencountered in obese asthmatic patients is their resistance to inhaled steroids, β2-agonists and leukotrene antagonists usedin asthma. Conflicting results have been obtained in studies of the effect of asthma on obesity. It is generally accepted that thedevelopment of obesity is more common in asthmatic patients due to decreased physical activity. Applying a personalized treatmentplan to treat asthmatic and obese patients and applying realistic treatment methods can help the patient lose weight. In addition,obese asthmatic patients should have more symptomatic perception, obesity causes changes in lung function and obese individualsshould be aware of the confusing effects of different comorbidities.

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1. Global Initiative for Asthma [GINA]. Global strategy for asthma management and prevention [Update2015]. Avaliable.from:http://www.ginasthma.org/local/ uploads/files/GINA_Report_2015.pdf.
2. Solé D, Aranda CS, Wandalsen GF. Asthma: epidemiology of disease control in Latin America – short review. Asthma Res Pract [Internet] 2017;3:4.
3. Turkish Thoracic Society Asthma Diagnosis and Treatment Guide, 2010, http://toraks.org.tr/ uploadFiles/book/file/410201117401
4. What is obesity and what causes it? Last reviewedFri 2 Nov 2018 By Yvette BrazierReviewed by Katherine Marengo LDN, RD.
5. Marko M, Pawliczak R. Obesity and asthma: risk, control and treatment. Adv Dermatology Allergol [Internet]. 2018;35:563-71.
6. Aeberli I, Beljean N, Lehmann R, l’Allemand D, Spinas GA, Zimmermann MB. The increase of fatty acidbinding protein aP2 in overweight and obese children: interactions with dietary fat and impact on measures of subclinical inflammation. Int J Obes [Internet]. 2008;32:1513-20.
7. Yadav U, medicine SS-C molecular, 2015 undefined. Cysteinyl leukotrienes (CysLTs): role in obesity-induced asthma. ingentaconnect.com [Internet]. [cited 2019 Apr 13]; Available from: https://www.ingentaconnect. com/content/ben/cmm/2015/00000015/00000007/ art00003
8. Grace J, Mohan A, pulmonary NL-C opinion in, 2019 undefined. Obesity and adult asthma: diagnostic and management challenges. journals.lww.com [Internet]. [cited 2019 Apr 13]; Available from: https://journals.lww.com/co-pulmonarymedicine/ Fulltext/2019/01000/Obesity_and_adult_asthma___ diagnostic_and.7.aspx
9. Everaere L, Ait-Yahia S, Molendi-Coste O, Vorng H, Quemener S, LeVu P, et al. Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity. J Allergy Clin Immunol [Internet]. 2016;138:1309-18.
10. Wu Y, Yue J, Wu J, et al. Obesity May Provide Pro-ILC3 Development Inflammatory Environment in Asthmatic Children. J Immunol Res [Internet] 2018:1-9.
11. Orfanos S, Jude J, Deeney BT, et al. Obesity increases airway smooth muscle responses to contractile agonists. Am J Physiol Cell Mol Physiol [Internet]. 2018;315:673-81.
12. Jeong A, Imboden M, Ghantous A, … AN-I journal of, 2019 undefined. DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma. mdpi.com [Internet]. [cited 2019 Apr 13]; Available from: https://www.mdpi. com/1660-4601/16/4/600
13. Yılmaz HEB, Yılmaz M, Şen N, et al. Investigation of the Relationship between Asthma and Visceral Obesity by Epicardial Fat Thickness Measurement. Turkish Thorac J [Internet]. 2019;20(1):1-5.
14. Goudarzi H, Konno S, Kimura H, … HM-TJ of A, 2018 undefined. Impact of Abdominal Visceral Adiposity on Adult Asthma Symptoms. Elsevier [Internet]. [cited 2019 Apr 13]; Available from: https://www.sciencedirect. com/science/article/pii/S2213219818307414
15. Liu Y, Zheng J, Zhang HP, et al. Obesity-Associated Metabolic Signatures Correlate to Clinical and Inflammatory Profiles of Asthma: A Pilot Study. Allergy Asthma Immunol Res [Internet]. 2018;10:628.
16. Milanese M, Giudice E del, immunopathologia DP-A et, 2018 undefined. Asthma, exercise and metabolic dysregulation in paediatrics. Elsevier [Internet]. [cited 2019 Apr 13]; Available from: https://www.sciencedirect.com/science/article/pii/ S0301054618300818
17. Sadeghimakki R, McCarthy HD. Interactive effects of adiposity and insulin resistance on the impaired lung function in asthmatic adults: cross-sectional analysis of NHANES data. Ann Hum Biol [Internet] 2019;1-7.
18. Rastogi D, Fraser S, Oh J, et al. Inflammation, Metabolic Dysregulation, and Pulmonary Function among Obese Urban Adolescents with Asthma. Am J Respir Crit Care Med [Internet] 2015;191:149-60.
19. Lu M, Wu B, Qiao R, et al.YD-J of clinical, 2019 undefined. No Associations Between Serum Lipid Levels or HOMA-IR and Asthma in Children and Adolescents: a NHANES Analysis. europepmc.org [Internet]. [cited 2019 Apr 13]; Available from: https:// europepmc.org/abstract/med/30759963
20. Barranco P, Delgado J, Sastre J, et al. Obesity is not Associated with Mild Asthma Diagnosis in a Population of Spanish Adults. J Asthma [Internet]. 2009;46:867-71.
21. Periyalil H, Wood L.HS-E, 2015 undefined. Macrophage activation, age and sex effects of immunometabolism in obese asthma. Eur Respir Soc [Internet]. [cited 2019 Apr 13]; Available from: https://erj.ersjournals.com/ content/45/2/388.short
22. Scott HA, Gibson PG, Garg ML, et al. Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype. Allergy [Internet] 2018 ;71:1037-47.
23. Grandi Silva A, Duarte Freitas P, Ferreira PG, Stelmach R, Carvalho-Pinto RM, Salge JM, et al. Effects of weight loss on dynamic hyperinflation in obese women asthmatics. J Appl Physiol [Internet]. 2019;126:413- 21.
24. Peters U, Subramanian M, Chapman DG et al. BMI but not central obesity predisposes to airway closure during bronchoconstriction. Respirology [Internet]. 2019 Jan 29 [cited 2019 Apr 13]; Available from: http:// doi.wiley.com/10.1111/resp.13478
25. Sin D, Thorax ES-, 2008 undefined. Obesity and the lung: 4• Obesity and asthma. thorax.bmj.com [Internet]. [cited 2019 Apr 13]; Available from: https:// thorax.bmj.com/content/63/11/1018.short
26. Ferretti A, Giampiccolo P, Cavalli A. Chest JM-E- , 2001 undefined. Expiratory flow limitation and orthopnea in massively obese subjects. Elsevier [Internet]. [cited 2019 Apr 13]; Available from: https://www.sciencedirect.com/science/article/pii/ S0012369215395982
27. Brazzale DJ, Pretto JJ, Schachter LM. Optimizing respiratory function assessments to elucidate the impact of obesity on respiratory health. Respirology [Internet]. 2015;20:715-21.
28. Scott HA, Wood LG, Gibson PG. Role of Obesity in Asthma: Mechanisms and Management Strategies. Curr Allergy Asthma Rep [Internet]. 2017;17:53.
29. Bédard A, Serra I, Dumas O, et al. Time-Dependent Associations Between Body Composition, Physical Activity, and Current Asthma in Women: A Marginal Structural Modeling Analysis. Am J Epidemiol [Internet] 2017;186:21-8.
30. Guilleminault L. Chronic cough and obesity. Pulm Pharmacol Ther [Internet]. 2019;55:84-8.
31. Tang M, Henderson R, Holbrook J. LQ-TJ of A, 2019 undefined. Does Obesity Increase Respiratory Tract Infections in Patients with Asthma? Elsevier [Internet]. [cited 2019 Apr 13]; Available from: https://www.sciencedirect.com/science/article/pii/ S221321981830610X
32. Kapadia S, Wei C, Bartlett S, Lang J. RW-R, 2014 undefined. Obesity and symptoms of depression contribute independently to the poor asthma control of obesity. Elsevier [Internet]. [cited 2019 Apr 13]; Available from: https://www.sciencedirect.com/ science/article/pii/S0954611114001991
33. Dixon AE, Shade DM, Cohen RI, Skloot GS, Holbrook JT, Smith LJ, et al. Effect of Obesity on Clinical Presentation and Response to Treatment in Asthma. J Asthma [Internet] 2006;43:553-8.
34. Okoniewski W, Lu KD, Forno E. Weight Loss for Children and Adults with Obesity and Asthma: A Systematic Review of Randomized Controlled Trials. Ann Am Thorac Soc [Internet]. 2019 Jan 3 [cited 2019 Apr 13];AnnalsATS.201810-651SR. Available from: https://www.atsjournals.org/doi/10.1513/ AnnalsATS.201810-651SR
35. Baltieri L, Cazzo E, Souza A de. SA-R, 2018 undefined. Influence of weight loss on pulmonary function and levels of adipokines among asthmatic individuals with obesity: One-year follow-up. Elsevier [Internet]. [cited 2019 Apr 13]; Available from: https:// www.sciencedirect.com/science/article/pii/ S0954611118303238
36. Schatz M, Allergy CCJ-A of, Immunology A&, 2003 undefined. The relationship of sex to asthma prevalence, health care utilization, and medications in a large managed care organization. Elsevier [Internet]. [cited 2019 Apr 13]; Available from: https://www.sciencedirect.com/science/article/pii/ S1081120610615335
37. Mannino DM, Homa DM, Akinbami LJ, et al. Surveillance for asthma--United States, 1980-1999. MMWR Surveill Summ [Internet]. 2002 Mar 29 [cited 2018;51:1-13.
38. Oliveira M, Vieira M, Coutinho D, et al, Pulmonology IP-, 2019 undefined. Severe asthma in obese patients: Improvement of lung function after treatment with omalizumab. Elsevier [Internet]. [cited 2019 Apr 13]; Available from: https://www.sciencedirect.com/ science/article/pii/S2531043718300369
39. Pawelec-Winiarz M, (Warsaw AK-…, 1960) P, 2018 undefined. Coexistence of asthma and the obesityhypoventilation syndrome. europepmc.org [Internet]. [cited 2019 Apr 13]; Available from: https://europepmc. org/abstract/med/30176621
40. André D, Horimoto C. MC-I, 2018 undefined. Epigallocatechin-3-gallate protects against the exacerbation of allergic eosinophilic inflammation associated with obesity in mice. Elsevier [Internet]. [cited 2019 Apr 13]; Available from: https:// www.sciencedirect.com/science/article/pii/ S1567576918302790
41. Zheng J, Zhang G, Li J. For HB-E review, 2019 undefined. Neutrophil elastase inhibitor suppresses oxidative stress in obese asthmatic rats by activating Keap1/Nrf2 signaling pathway. europeanreview. org [Internet]. [cited 2019 Apr 13]; Available from: https://www.europeanreview.org/wp/wp-content/ uploads/361-369.pdf.