The findings of corneal specular microscopy in patients with keratoconus

The findings of corneal specular microscopy in patients with keratoconus

Aim: The aim of this study was to determine the correlation of corneal endothelial cell density, coefficient of variation and hexagonal cell ratio with the stages of keratoconus and corneal thickness.Material and Methods: The study included 102 eyes from 51 patients. The corneal topography was performed using the Sirius corneal topographic device and the examination of the endothelium was performed using Nidek CEM-530. The patients were divided into groups in accordance with keratometry values (group 1: K2 52 D) and thinnest cornea thickness (group 1:> 450 μm, group 2: 400-450 μm, group 3:

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  • 1. Krachme JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol 1984;28:293‑322.
  • 2. Saini JS, Saroha V, Singh P, et al. Keratoconus in asian eyes at a tertiary eye care facility. Clin Exp Optom 2004;87:97‑101.
  • 3. Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998;42:297-319.
  • 4. Bykhovskaya Y, Margines B, Rabinowitz YS. Genetics in keratoconus: where are we? Eye Vis (Lond) 2016;3:16.
  • 5. Goebels S, Eppig T, Wagenpfeil S, et al. Stagingof keratoconus indices regarding tomography,topography, and biomechanical measurements.Am J Ophthalmol 2015;159: 733-8.
  • 6. El-Agha MS, El Sayed YM, Harhara RM, et al. Correlation of corneal endothelial changes with different stages of keratoconus. Corneal 2014;33:707-11.
  • 7. Ghosh S, Mutalib HA, Kaur S, et al. Corneal cell morphology in keratoconus: a confocal microscopic observation. Malays J Med Sci 2017;24:44-54.
  • 8. Bozkurt B, Yılmaz M, Meşen A, et al. Correlation of corneal endothelial cell density with corneal tomographic parameters in eyes with Keratoconus. Turk J Ophthalmol 2017;47:255-60.
  • 9. Lee S, Jung G, Lee HK. Comparison of contact lens corrected quality of visionand life of keratoconus and myopic patients. Korean J Ophthalmol 2017;31:489-96.
  • 10. Baenninger PB, Bachmann LM, Wienecke L, et al. Effects and advers events after CXL for keratoconus are independent of age: a 1-year follow-upstudy. Eye (Lond) 2014;28:691-5.
  • 11. Alio JL, Vega-Estrada A, Esperanza S, et al. Intrastromal corneal ring segments: how successful is the surgical survey of ophthalmology treatment of keratoconus? Middle East Afr J Ophthalmol 2014;21:3-9.
  • 12. Zhang YM, Wu SQ, Yao YF. Long-term comparison of full bed deep anterior lamellar keratoplasty and penetrating keratoplasty in treating keratoconus. J Zhejiang Univ Sci B.2013;14:438-50.
  • 13. Kymionis GD, Portaliou DM, Diakonis VF, et al. Corneal collagen crosslinking with riboflavin and ultraviolet-A irradiation in patients with thin corneas. Am J Ophthalmol 2012;153:24-8.
  • 14. Spoerl E, Mrochen M, Sliney D, et al. Safety of UVA-riboflavin crosslinking of the cornea. Cornea 2007;26:385-9.
  • 15. Schaub F, Enders P, Adler W, et al. Impact of donor graft quality on deep anterior lamellar Keratoplasty (DALK). BMC Ophthalmology 2017;17:204.
  • 16. Sturbaum CW, Peiffer RL Jr. Pathology of corneal endothelium in keratoconus. Ophthalmologica1993;206:192-208.
  • 17. Uçakhan OO, Kanpolat A, Ylmaz N, et al. Invivo confocal microscopy findings in keratoconus. Eye Contact Lens 2006;32:183-91.
  • 18. Bitirgen G, Ozkagnici A, Bozkurt B. et al. Invivo corneal confocal microscopic analysis in patients with keratoconus. Int J Ophthalmol 2015;8:534-9.
  • 19. Timucin OB, Karadag MF, Cinal A, et al. Assessment of corneal endothelial cell density in patients with keratoconus not using contact lenses. Cont Lens Anterior Eye 2013;36:80-5.
  • 20. Yeniad B, Yilmaz S, Bilgin LK. Evaluation of the microstructure of cornea by in vivo confocal microscopy in contact lens wearing and non-contact lens wearing keratoconus patients. Cont Lens Anterior Eye 2010;33:167–70.
  • 21. Mocan MC, Yilmaz PT, Irkec M, et al. Invivo confocal microscopy for the evaluation of corneal microstructure in keratoconus. Curr Eye Res 2008;33:933-9
  • 22. Weed KH, MacEwen CJ, Cox A, et al. et al. Quantitative analysis of corneal microstructure in keratoconus utilising in vivo confocal microscopy. Eye (Lond) 2007;21:614-23.
  • 23. Kaldawy RM, Wagner J, Ching S, Evidence of apoptotic cell death in keratoconus. Cornea 2002;21:206-9.
  • 24. Matsuda M, Suda T, Manabe R. Quantitativeanalysis of endothelial mosaic pattern changes in anterior keratoconus.Am J Ophthalmol 1984;98:43-9.
  • 25. Edmonds CR, Wung SF, Husz MJ, et al. Corneal endothelial cell count in keratoconus patients after contact lens wear. Eye Contact Lens 2004;30:54-8.
  • 26. Matsuda M, MacRae SM, Inaba M, et al. Theeffect of hard contact lens wear on the keratoconic corneal endothelium after penetrating keratoplasty. Am J Ophthalmol 1989;107:246-51.
  • 27. Schoessler JP. The corneal endothelium following 20 years of PMMA contact lens wear. CLAO J 1987;13:157-60.
  • 28. Magdum RM, Mutha N, Maheshgauri R. A study of corneal endothelial changes in soft contact lens wearers using non‑contact specular microscopy. Razmjoo H, Ghoreishi SM, Mohammadi Z, et al. Comparison of the findings of cross-linking. Adv Biomed Res 2015;4:52.
  • 29. Gokhale NS. Corneal endothelial damage after collagencross linking treatment. Cornea 2011;30:1495-8.
  • 30. Hafezi F, Mrochen M, Iseli HP, et al. Collagen crosslinking with ultraviolet A and hypoosmolar riboflavin solution in thin corneas. J Cataract Refract Surg 2009;35:621-4.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi