Determination of normal lung volume using computed tomography in children and adolescents

Aim: To determine the normal reference values for both lung inspiratory volumes in children and adolescents with routine computed tomography (CT) and compare relationships with gender and age.Material and Methods: This retrospective study evaluated 100 cases (53 males, 47 females) with normal chest CT (age range: 4-17 years). The cases were divided into three subgroups based on age as 4-7 years (preschool; n=31), 8-12 years (school-age; n=30) and 13-17 years (adolescent; n=39). Demographic data like sex and age were recorded. Right, left and total lung volumes were calculated with automatic volumetric software. Volume comparisons were made for lungs, gender and age groups. Statistical analysis used the Wilcoxon signed-ranks test, Mann-Whitney U test and Tamhane test.Results: For all cases the right lung volume was greater than the left lung (p

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1. Porcel JM, Leung CC, Restrepo MI, et al. Year in review 2012: lung cancer, respiratory infections, tuberculosis, pleural diseases, bronchoscopic intervention and imaging. Respirology 2013;18:573-83.
2. Garfield JL, Marchetti N, Gaughan JP, et al. Total lung capacity by plethysmography and high-resolution computed tomography in COPD. Int J Chron Obstruct Pulmon Dis 2012;7:119-26.
3. de Jong PA, Lindblad A, Rubin L, et al. Progression of lung disease on computed tomography and pulmonary function tests in children and adults with cystic fibrosis. Thorax 2006;61:80-5.
4. Chen F, Kubo T, Shoji T, et al. Comparison of pulmonary function test and computed tomography volumetry in living lung donors. J Heart Lung Transplant 2011;30:572-5.
5. Kauczor HU, Heussel CP, Fischer B, et al. Assessment of lung volumes using helical CT at inspiration and expiration: comparison with pulmonary function tests. AJR Am J Roentgenol 1998;171:1091-5.
6. Kendrick AH. Comparison of methods of measuring static lung volumes. Monaldi Arch Chest Dis 1996;51:431-9.
7. Haas M, Hamm B, Niehues SM. Automated lung volumetry from routine thoracic CT scans: how reliable is the result? Acad Radiol 2014;21:633-8.
8. Shin JM, Kim TH, Haam S, et al. The repeatability of computed tomography lung volume measurements:Comparisons in healthy subjects, patients with obstructive lung disease, and patients with restrictive lung disease. PLoS One 2017;12:e0182849.
9. Gruber-Rouh T, Thalhammer A, Klingebiel T, et al. Computed tomography-guided biopsies in children: accuracy, efficiency and dose usage. Ital J Pediatr 2017;43:4.
10. Gilchrist FJ, Buka R, Jones M, et al. Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. BMJ Paediatr Open 2018;2:e000367.
11. Larson DB, Molvin LZ, Wang J, et al. Pediatric CT quality management and improvement program. Pediatr Radiol 2014;44:519-24.
12. Stein JM, Walkup LL, Brody AS, et al. Quantitative CT characterization of pediatric lung development using routine clinical imaging. Pediatr Radiol 2016;46:1804-12.
13. Wen Y, Kai S, Yong-Gang Zet al. Relationship between Lung Volume and Pulmonary Function in Patients With Adolescent Idiopathic Scoliosis: Computed Tomographic-based 3-Dimensional Volumetric Reconstruction of Lung Parenchyma. Clin Spine Surg 2016;29:396-400.
14. Molho M, Shulimzon T, Benzaray S, et al. Importance of inspiratory load in the assessment of severity of airways obstruction and its correlation with CO2 retention in chronic obstructive pulmonary disease. Am Rev Respir Dis 1993;147:45-9.
15. Taube C, Kanniess F, Grönke L, et al. Reproducibility of forced inspiratory and expiratory volumes after bronchodilation in patients with COPD or asthma. Respir Med 2003;97:568-77.
16. Coxson HO, Rogers RM, Whittall KP, et al. A quantification of the lung surface area in emphysema using computed tomography. Am J Respir Crit Care Med 1999;159:851-6.
17. Brody AS, Molina PL, Klein JS, et al. High-resolution computed tomography of the chest in children with cystic fibrosis: support for use as an outcome surrogate. Pediatr Radiol 1999;29:731-5.
18. Robinson TE, Leung AN, Northway WH, et al. Spirometer-triggered high-resolution computed tomography and pulmonary function measurements during an acute exacerbation in patients with cystic fibrosis. J Pediatr 2001;138:553-9.
19. Bonnel AS, Song SM, Kesavarju K, et al. Quantitative air-trapping analysis in children with mild cystic fibrosis lung disease. Pediatr Pulmonol 2004;38:396-405.
20. Mott LS, Graniel KG, Park J, et al. Assessment of early bronchiectasis in young children with cystic fibrosis is dependent on lung volume. Chest 2013;144:1193-8.