Improved treatment of recurrent aphthous stomatitis with sodium pentaborate pentahydrate (NaB)

Aim: Chlorhexidine (CHX) and benzydamine hydrochloride (B-HCl) combination treatment (Kloroben™ spray) was compared with sodium pentaborate pentahydrate (NaB, also called boron) treatment with regard to their effects in the recovery of recurrent aphthous stomatitis (RAS). Materials and Methods: We assessed the treatment results by evaluating ulcer radius and VAS results. Seventy-one patients with clinically diagnosed minor RAS were selected for the study based on inclusion and exclusion criteria. Group 1 was treated with a 3% solution of NaB and group 2 was treated with Kloroben spray (45 mg benzydamine HCl and 36 mg chlorhexidine gluconate) for 1 week. Results: After the treatments, there were statistically significant decreases in VAS scores in both Group 1 (p

PDF

___

1. Ziaudeen S, Ravindran R. Assessment of Oxidant- Antioxidant Status and Stress Factor in Recurrent Aphthous Stomatitis Patients: Case Control Study. J Clin Diagn Res 2017;11:ZC01-ZC4.
2. 2Cardoso JA, dos Santos Junior AA, Nunes MLT, et al. Salivary Alpha-Amylase Enzyme, Psychological Disorders, and Life Quality in Patients with Recurrent Aphthous Stomatitis. Int J Dent 2017;2017:5269856.
3. Montgomery-Cranny JA, Wallace A, Rogers HJ, et al. Management of recurrent aphthous stomatitis in children. Dent Update 2015;42:564-72.
4. Preeti L, Magesh K, Rajkumar K, et al. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol 2011;15:252-6.
5. Belenguer-Guallar I, Jiménez-Soriano Y, Claramunt- Lozano A. Treatment of recurrent aphthous stomatitis. A literature review. J Clin Exp Dent 2014;6:e168-e74.
6. Torres-Lagares D, Gutierrez-Perez JL, Hita-Iglesias P, et al. Randomized, double-blind study of effectiveness of intra-alveolar application of chlorhexidine gel in reducing incidence of alveolar osteitis and bleeding complications in mandibular third molar surgery in patients with bleeding disorders. J Oral Maxillofac Surg 2010;68:1322-6.
7. Cosyn J, Wyn I, De Rouck T, et al. Subgingival chlorhexidine varnish administration as an adjunct to same-day full-mouth root planing. I. Clinical observations. J Periodontol 2007;78:430-7.
8. Edgar NR, Saleh D, Miller RA. Recurrent Aphthous Stomatitis: A Review. J Clin Aesthet Dermatol 2017;10:26-36.
9. Sanghai P, Nandgude T, Poddar S. Formulation of Bilayer Benzydamine HCl Patch Targeted For Gingivitis. J Drug Deliv 2016;2016:7598398.
10. Karavana S, Sezer B, Guneri P, et al. Efficacy of topical benzydamine hydrochloride gel on oral mucosal ulcers: an in vivo animal study. Int J Oral Maxillofac Surg 2011;40:973-8.
11. Aysan E, Idiz UO, Elmas L, et al. Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled Trial. J Invest Surg 2017;30:187-92.
12. Dogan A, Demirci S, Caglayan AB, et al. Sodium pentaborate pentahydrate and pluronic containing hydrogel increases cutaneous wound healing in vitro and in vivo. Biol Trace Elem Res 2014;162:72-9.
13. Embil J, Stephens R, Manuel F. Prevalence of recurrent herpes labialis and aphthous ulcers among young adults on six continents. CMAJ 1975;113:627-30.
14. Cingi C, Songu M, Ural A, et al. Effect of chlorhexidine gluconate and benzydamine hydrochloride mouth spray on clinical signs and quality of life of patients with streptococcal tonsillopharyngitis: multicentre, prospective, randomised, double-blinded, placebocontrolled study. J Laryngol Otol 2011;125:620-5.
15. Hunter L, Addy M. Chlorhexidine gluconate mouthwash in the management of minor aphthous ulceration. A double-blind, placebo-controlled cross-over trial. Br Dent J 1987;162:106-10.
16. Scully C, Porter S. Oral mucosal disease: recurrent aphthous stomatitis. Br J Oral Maxillofac Surg 2008;46:198-206.
17. Edres M, Scully C, Gelbier M. Use of proprietary agents to relieve recurrent aphthous stomatitis. Br Dent J 1997;182:144-6.
18. Pemberton MN. Prescribing for Mucosal Disease in Primary Dental Care. Prim Dent J 2014;3:48-53.
19. Soylu Ozler G, Okuyucu Ş, Akoğlu E. The efficacy of sucralfate and chlorhexidine as an oral rinse in patients with recurrent aphthous stomatitis. Advances in Med 2014;2014:986203.
20. Candelli M, Carloni E, Armuzzi A, et al. Role of sucralfate in gastrointestinal diseases. Panminerva Med 2000;42:55-9.
21. Masuelli L, Tumino G, Turriziani M, et al. Topical use of sucralfate in epithelial wound healing: clinical evidences and molecular mechanisms of action. Recent Pat Inflamm Allergy Drug Discov 2010;4:25- 36.
22. Matthews R, Scully C, Levers B, et al. Clinical evaluation of benzydamine, chlorhexidine, and placebo mouthwashes in the management of recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1987;63:189-91.
23. Demirci S, Dogan A, Karakus E, et al. Boron and poloxamer (F68 and F127) containing hydrogel formulation for burn wound healing. Biol Trace Elem Res 2015;168:169-80.
24. Kaymaz B, Golge UH, Ozyalvaclı G, et al. Effects of boric acid on the healing of Achilles tendons of rats. Knee Surg Sports Traumatol Arthrosc 2016;24:3738- 44.
25. Benderdour M, Hess K, Dzondo-Gadet M, et al. Boron Modulates Extracellular Matrix and TNFα Synthesis in Human Fibroblasts. Biochem Biophys Res Commun 1998;246:746-51.
26. Tepedelen BE, Soya E, Korkmaz M. Boric acid reduces the formation of DNA double strand breaks and accelerates wound healing process. Biol Trace Elem Res 2016;174:309-18.