High fructose consumption may have part in the pathophysiology of coronary artery ectasia

Aim: A coronary artery may partly become a half or one diameter larger than an adjoining normal one as observed on angiograms,which is called coronary artery ectasia (CAE). There is strong evidence that oxidative stress and inflammation may contribute to theCAE pathophysiology, potentially due to higher fructose intake. Our study aims to determine the effects of the amount of fructoseconsumed on isolated CAE.Material and Methods: The study group consists of the patients with stable angina pectoris who had coronary angiography (CAG)reports dated from December 2018 to April 2019. Based on these reports, sampling was made as follow: the patient or CAE groupof 50 patients also with isolated CAE and the control group of 50 patients with normal coronary flow pattern (NCF). A comparativeanalysis was performed using the exact data of both groups including nutrient consumption.Results: The patient group with higher high-sensitivity C-reactive protein levels (p = 0.029), greater platelet count (p = 0.015), andincreased hypertension rate (p = 0.012) were observed to have higher energy in total (p = 0.008), carbohydrate (p = 0.003), andfructose intake (p

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1. Yilmaz H, Sayar N, Yilmaz M, et al. [Coronary artery ectasia: clinical and angiographical evaluation]. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 2008;36:530-5.
2. Markis JE, Joffe CD, Cohn PF, et al. Clinical significance of coronary arterial ectasia. Am J Cardiol 1976;37: 217-22.
3. Kurum T, Dogutan H. [Nonatherosclerotic causes of coronary artery disease]. Anadolu kardiyoloji dergisi : AKD = Anatol J Cardiol 2003;3:348-52.
4. Sen N, Ozcan F, Uygur B, et al. [Elevated serum uric acid levels in patients with isolated coronary artery ectasia]. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 2009;37:467- 72.
5. Akturk E, Askin L, Nacar H, et al. Association of serum prolidase activity in patients with isolated coronary artery ectasia. Anatol J Cardiol 2018;19:110-6.
6. Gurlek A, Esenboga K, Ozcan OU, et al. Serum nitric oxide levels in patients with coronary artery ectasia. Anatol J Cardiol 2016;16:947-52.
7. Kundi H, Gok M, Cetin M, et al. Relationship between platelet-to-lymphocyte ratio and the presence and severity of coronary artery ectasia. Anatol J Cardiol 2016;16:857-62.
8. Erdogan T, Kocaman SA, Cetin M, et al. Increased YKL40 levels in patients with isolated coronary artery ectasia: an observational study. Anadolu kardiyoloji dergisi : AKD = Anatol J Cardiol 2013;13:465-70.
9. Tappy L, Le KA, Tran C, et al. Fructose and metabolic diseases: new findings, new questions. Nutrition (Burbank, Los Angeles County, Calif) 2010;26:1044-9.
10. Cirillo P, Pellegrino G, Conte S, et al. Fructose induces prothrombotic phenotype in human endothelial cells : A new role for "added sugar" in cardio-metabolic risk. J Thromb Thrombolysis 2015;40:444-51.
11. Conti FF, Brito Jde O, Bernardes N, et al. Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause. BMC Cardiovasc Disord 2014;14:185.
12. Jaiswal N, Maurya CK, Arha D, et al. Fructose induces mitochondrial dysfunction and triggers apoptosis in skeletal muscle cells by provoking oxidative stress. Apoptosis : An International J on Programmed Cell Death 2015;20:930-47.
13. Aksu T, Uygur B, Durukan Kosar M, et al. [Coronary artery ectasia: its frequency and relationship with atherosclerotic risk factors in patients undergoing cardiac catheterization]. Anadolu kardiyoloji dergisi : AKD = Anatol J Cardiol 2011;11:280-4.
14. Ozturk S, Yetkin E, Waltenberger J. Molecular and cellular insights into the pathogenesis of coronary artery ectasia. Cardiovascular pathology : The Society For Cardiovascular Pathology 2018;35:37-47.
15. Yetkin E, Waltenberger J. Novel insights into an old controversy: is coronary artery ectasia a variant of coronary atherosclerosis? Clinical research in cardiology : The German Cardiac Society 2007;96: 331-9.
16. Yetkin E, Acikgoz N, Aksoy Y, Bariskaner E, Sivri N, Akturk E, et al. Decreased carotid intima-media thickness in patients with coronary artery ectasia compared with patients with coronary artery disease. Coronary Artery Disease 2005;16:495-8.
17. Yildirim N, Tekin IO, Arasli M, et al. Further increase in the expression of activation markers on monocytederived dendritic cells in coronary artery disease patients with ectasia compared to patients with coronary artery disease alone. Mediators of Inflammation 2010;2010:748919.
18. Turhan H, Erbay AR, Yasar AS, et al.Comparison of C-reactive protein levels in patients with coronary artery ectasia versus patients with obstructive coronary artery disease. Am J Cardiol 2004;94:1303- 6.
19. Ozkan B, Orscelik O, Yildirim Yaroglu H, et al. Association between serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris. Anatol J Cardiol 2019;22:250-5.
20. Sezen Y, Bas M, Polat M, et al. The relationship between oxidative stress and coronary artery ectasia. Cardiology journal 2010;17:488-94.
21. Altiparmak IH, Kaya Z, Sezen H, et al. [The relation of serum paraoxonase-1 activity with isolated coronary artery ectasia: an observational study]. Anadolu kardiyoloji dergisi : AKD = Anatol J Cardiol 2012;12: 307-12.
22. Breda J, Jewell J, Keller A. The Importance of the World Health Organization Sugar Guidelines for Dental Health and Obesity Prevention. Caries Research 2019; 53:149-52.
23. Livesey G, Taylor R. Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies. Am J Clin Nutr 2008; 88:1419-37.
24. Delbosc S, Paizanis E, Magous R, et al. Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance, the fructose-fed rat. Atherosclerosis 2005;179:43-9.
25. Isik T, Ayhan E, Uyarel H, et al. Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasia. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 2013;41:123-30.
26. Cigliano L, Spagnuolo MS, Crescenzo R, et al. ShortTerm Fructose Feeding Induces Inflammation and Oxidative Stress in the Hippocampus of Young and Adult Rats. Molecular Neurobiology 2018;55:2869-83.
27. Velickovic N, Djordjevic A, Vasiljevic A, et al. Tissuespecific regulation of inflammation by macrophage migration inhibitory factor and glucocorticoids in fructose-fed Wistar rats. Br J Nutr 2013;110:456-65.
28. Li JM, Ge CX, Xu MX, et al. Betaine recovers hypothalamic neural injury by inhibiting astrogliosis and inflammation in fructose-fed rats. Molecular Nutrition & Food Research 2015;59:189-202.