Gastrointestinal system-derived secondary gynecologic tumors: 10 years experience at a single center
Gastrointestinal system-derived secondary gynecologic tumors: 10 years experience at a single center
Aim: To perform a retrospective review of gynecologic malignancies originating from gastrointestinal system (GİS).Material and Methods: The study included 35 patients who underwent surgery at Gaziantep University, Faculty of Medicine, Department of Gynecology and Obstetrics from January 2007 to December 2017 and were diagnosed with secondary gynecological malignancies originating from GİS. The patients’ age, primary tumor, metastatic tumor localization and size were recorded. The malignancies were classified based on origin, as those arising from the colon, appendix, pancreas, stomach, peritoneum, and those of an unknown origin.Results: The mean age of the patients was 50.8 years (min: 24, max: 98) and the mean tumor diameter was 9.8 cm (min: 2 cm, max: 23 cm). Malignancies originating from the colon were most common secondary gynecologic malignancies. The primary tumor was localized at the colon in 21 patients (60%), stomach in eight (22.8%), and in the pancreas in one patient, appendix in one patient, peritoneum in one patient (2.8%). The origin of the primary tumor could not be determined in three patients (8.5%). Of the malignancies originating from the colon (n=21), 16 (76.1%) metastasized to the ovaries, four (19%) to the vagina, one (4.7%) to the cervix, while all tumors originating from the stomach, peritoneum, pancreas, appendix and those derived from the GIS without specific origin metastasized to the ovaries. Of the ovarian metastases, 26 (86.6%) were bilateral while four (13.3%) were unilateral.Conclusion: Female genital system is among the substantial targets of metastasis of GIS-derived tumors. Metastatic tumors have a more aggressive behavior. Metastatic tumors must be distinguished from primary tumors as treatment modalities differ in these tumors. A multidisciplinary approach should be employed in the diagnosis, management and follow-up of cases, and the genital system should be screened carefully during both preoperative assessment and postoperative follow-up in patients with primary GIS malignancies
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- 1.
Güngördük K, Gülseren V, Sancı M. Current approach to metastasis of extra-genital system malignancies to the female genital tract. JCEI 2015;6:406-13.
- 2.
Karpathiou G, Chauleur C, Hathroubi S, et al. Secondary tumors of the gynecologic tract: a clinicopathologic analysis. Int J Gynecol Pathol 2018;10.
- 3.
Neto AG, Deavers MT, Silva EG, et al. Metastatic tu¬mors of the vulva: a clinicopathologic study of 66 cas¬es. Am J Surg Pathol 2003;27:799-804.
- 4.
Ren K, Ma X, Wang F,et al. Metachronous me¬tastasis from the right colon adenocarcinoma to the vulva: an unusual report and literature review. Int J Clin Exp Pathol 2015;8:1000-6.
- 5.
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009;59:225-49.
- 6.
Fu YS, Reagan JW. Pathology of the uterine cervix, vagina, and vulva. Teratology 1989;397.
- 7.
Berhili S, El Khannoussi B, Kadiri S, et al. Uterine cer¬vix metastasis from a sigmoid adenocarcinoma: a rare presentation of an uncommon tumor. Gynecol Oncol Res Pract 2014;1-6.
- 8.
William P, Abraham M. Adenocarcinoma of the cervix. Am J Obstet GynecoI 1962;84:367–74.
- 9.
Korhonen M, Stenback F. Adenocarcinoma meta¬static to the uterine cervix. Gynecol Obstet Invest 1984;17:57-65.
- 10.
Yavuz E, Çakır Ç, Akbaş N, et al. Overin primer ve metastatik karsinomlarının ayırıcıtanısında immuno histokimyanın değeri. Tü rk Patoloji Dergisi 2002;18:15-9.
- 11.
Taner CE, Elveren B, Altınboga O, Clinical Analysis of 26 Cases with non-gynecologic metastatic tumors of the ovary. Gynecol Obstet Reprod Med 2009;15:44-6.
- 12.
Gottwald L, Piekarski J, Jeziorski A. The role of cyto¬reductive surgery for non-genital tract metastases to the ovary. Transworld Research Network 2010;101-22.
- 13.
Turan T, Bozok S, Kose MK. Primer Odağı Ekstra genital Organlar olan Metastatik Over Tümörleri. TürkJin Onk Dergisi 2006;9:55-61.
- 14.
Skirnisdottir I, Garmo H, Holmberg L. Non-genital tract metastases to the ovaries presented as ovarian tumors in Sweden 1990–2003: occurrence, origin and survival compared to ovarian cancer. Gynecol Oncol 2007;105:166-71.
- 15.
Uzunlar O, Baser E, Akbay S, Overe Metastaz Yapan Düşük Dereceli Müsinöz Apendiks Neoplazisive Psödomik somaperitonei Olgusu: Jinekolojik Onkoloji Perspektifinden Yaklaşım. Türk Jin Onk Dergisi 2012;15:11-5.
- 16.
Bayar Ü, Kaya E. Metastatik Over Tümörleri. T Klin Jinekol Obst 2004;14:52-63.