Examination of pulmonary embolism in patients in a university hospital
Examination of pulmonary embolism in patients in a university hospital
Aim: Pulmonary embolism (PE) is responsible for 5-15% of hospital deaths. The rate of mortality from PE in untreated cases is about25-30%, while this rate drops down to 2-8% in treated cases. In this study, we aimed to investigate general features of the patientshospitalized in our center due to PE and the factors affecting prognosis.Material and Methods: Patients hospitalized due to PE in Harran University Medical Faculty Hospital between January 2015 andDecember 2017. Patients’ demographic data, comorbidities, hemogram outcomes at the time of admission, liver function tests, renalfunction tests, electrolytes and cardiac markers, status of the patients during follow-up (referral to intensive care unit, exitus, wardfollow-up) and PE clinical picture (massive, submassive, nonmassive) were recorded. All patients requiring hospitalization due to PEwere included in the study, while patients with chronic thromboembolic pulmonary disease, those requiring recurrent hospitalizationand patients discharged on own demand were excluded from the study.Results: The study included 40 (38.8%) male and 63 (61.2%) female patients with a mean age of 66±18.1 years. The mean duration ofhospitalization was found as 11 days. Of the patients included in this study, 7.7% (n=8) were diagnosed with massive, 10.6% (n=11)with submassive, and 81.5% (n=84) with non-massive PE. Four patients (3.8%) were accepted as in-hospital exitus, 30 (29.1%)patients were transferred to the intensive care unit and 69 (66.9%) patients were followed-up in the thoracic diseases service. Whenpatients diagnosed with non-massive PE were compared with those diagnosed with submassive and massive PE; the levels ofmagnesium (p=0.003), and troponin (p=0.000) were statistically significantly higher in the group diagnosed with submassive andmassive PE. When the groups with and without the need for intensive care were compared, platelet counts were statistically lower inthe group which required intensive care (p=0.038).Conclusion: More often hospitalization is needed in female patients due to PE. Although routine laboratory tests give a partialinformation about the prognosis of PE, cardiac markers are the most commonly used in clinical practice.
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- 1. Arseven O. Pulmoner Tromboembolizm. Özlü T (editör). Solunum Sistemi ve Hastalıkları Temel Başvuru Kitabı. Cilt I. İstanbul, İstanbul Tıp Kitapevi 2010;1185-219.
- 2. Martinez C, Cohen AT, Bamber L, et al. Epidemiology of first and recurrent venous thromboembolism: a population-based cohort study in patients without active cancer. Thromb Haemost 2014;112:255-63.
- 3. Puurunen MK, Gona PN, Larson MG, et al. Epidemiology of venous thromboembolism in the Framingham Heart Study. Thromb Res 2016;145:27-33.
- 4. Arseven O, Sevinç C, Alataş F, et al. Türk Toraks Derneği Pulmoner Trombo-embolizm Tanı ve Tedavi Uzlaşı Raporu. Türk Toraks Dergisi 2015;10:1-49.
- 5. Demir M, Erdemli B, Kurtoğlu M, et al. Ulusal Venöz Tromboembolizm Profilaksi ve Tedavi Klavuzu 2010; 1-127.
- 6. Konstantinides SV, Torbicki A, Agnelli G, et al. ESC guidelines on the diagnosis and management of acute pulmonary embolism.Eur Heart J 2014;35:3033-69.
- 7. Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). Lancet 1999;353:1386-9.
- 8. Kostadima E, Zakynthinos E. Pulmonary embolism: pathophysiology, diagnosis, treatment. Hellenic J Cardiol 2007;48:94-107.
- 9. Bateson D, Butcher BE, Donovan C, et al. Risk of venous thromboembolism in women taking the combined oral contraceptive: A systematic review and meta-analysis.Royal Australian College of General Practitioners 2016;59-67.
- 10. Johnson SA, Eleazer GP, Rondina MT. Pathogenesis, Diagnosis, and Treatment of Venous Thromboembolism in Older Adults. J Am Geriatr Soc 2016;64;1869-78.
- 11. Caprini JA. Update on Risk Factors for Venous Thromboembolism. Am J Med 2005;1-10.
- 12. Miniati M, Prediletto R, Formichi B, et al. Accuracy of clinical assessment in the diagnosis of pulmonary embolism. Am J Respir Crit Care Med 1999;159:864- 71.
- 13. Jiménez D, Escobar C, Martí D. Association of anaemia and mortality in patients with acute pulmonary embolism. Thromb Haemost 2009;102:153-8.
- 14. Donze J, Labarere J, Mean M, et al. Prognostic importance of anaemia in patients with acute pulmonary embolism. Thromb Haemost 2011;106:289-95.
- 15. Şen HS, Abakay Ö, Taylan M, et al. The importance of mean platelet volume in early mortality of pulmonary embolism. Clinical and Experimental Investigations 2013;4:298-301.
- 16. Pazarlı AC, Bekar L. Clinical Utility of Red Blood Cell Distribution Width Parameter in Patients with Hemodynamically Stable Acute Pulmonary Embolism. Eurasian J Pulmonol 2014;16:27-30.
- 17. Aslan S, Meral M, Akgun M, et al. Liver dysfunction in patients with acute pulmonary embolism. Hepatol Res 2007;37:205-13.
- 18. Vizcaychipi M, Burt C, Burnstein R. Pulmonary embolism: An Unusual Cause Of Acute Liver Failure. Internet J Emergency and Intensive Care Med 2006;10.
- 19. Chang C, Fu C, Fan P, et al. Acute kidney injury in patients with pulmonary embolism: a populationbased cohort study. Medicine 2017;96:5822.
- 20. Kuo TH, Li HY, Lin SH. Acute kidney injury and risk of deep vein thrombosis and pulmonary embolism in Taiwan: A nationwide retrospective cohort study. Thromb Res 2017;151:29-35.
- 21. Al-Dorzi HM, Al-Heijan A, Tamim HM, et al. Renal failure as a risk factor for venous thromboembolism in critically Ill patients: a cohort study. Thrombosis Res 2013;132:671-5.