Evaluation of macular thickness and retinal nerve fiber layer thickness in pediatric patients with malnutrition

Evaluation of macular thickness and retinal nerve fiber layer thickness in pediatric patients with malnutrition

Aim: To evaluate macular thickness and retinal nerve fiber layer thickness in pediatric patients with primary malnutrition.Material and Methods: Macular and peripapillary retinal nerve fiber layer thicknesses of 90 pediatric patients with primary malnutritionwere measured by spectral field optical coherence tomography. These findings were compared with the data of 50 age-matchedhealthy children.Results: There were no statistically significant differences in terms of age, gender and refractive status between the groups. In theprimary malnutrition group, 17 of 90 patients had decreased retinal nerve fiber layer values. There were no patients with decreasedretinal nerve fiber layer values in the control group and this difference was statistically significant (p

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  • 1. Li HQ. Research advance in assessment of nutritional status of children. Zhongguo Dang Dai Er Ke ZaZhi 2014;16:5-10.
  • 2. Galloway R, Bundy DAP, Silva Nd, et al. Child and Adolescent Health and Development. 3rd edition. Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2017.
  • 3. De Onis M, Blössner M, Borghi E. Prevalence and trends of stunting among pre-school children, 1990- 2020. Public Health Nutr 2012;15:142-8.
  • 4. Müller O, Krawinkel M. Malnutrition and health in developing countries. CMAJ 2005;173:279-86.
  • 5. Gladstone M, Mallewa M, Alusine Jalloh A, et al. Assessment of neurodisability and malnutrition in children in Africa. Semin Pediatr Neurol 2014;21:50-7.
  • 6. Grantham-McGregor S, Cheung YB, Cueto S, et al. International Child Development Steering Group. Developmental potential in the first 5 years for children in developing countries. Lancet 2007;369:60-70.
  • 7. Bryan J, Osendarp S, Hughes D, et al. Nutrients for cognitive development in school-aged children. Nutr Rev 2004;62:295-306.
  • 8. Algarín C, Peirano P, Garrido M, et al. Iron deficiency anemia in infancy: long-lasting effects on auditory and visual system functioning. Pediatr Res 2003;53:217- 23.
  • 9. Durmaz S, Karagol U, Deda G, et al. Brainstem auditory and visual evoked potentials in children with proteinenergy malnutrition. Pediatr Int 1999;41:615-9.
  • 10. Bonavolontà O, Ferrante P, Rosati P. Retinal and lens damages observed in young rats undergoing protein malnutrition in selected stages of their growth. Int J Vitam Nutr Res 1989;59:117-21.
  • 11. Bonavolontà O, Ferrante P, Terracciano L, et al.Further researches about retinal damages and dietary protein imbalance in growing rats. Int J Vitam Nutr Res. 1991;61:251-7.
  • 12. Age-Related Eye Disease Study Research Group. The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1. Control Clin Trials. 1999;20:573-600.
  • 13. Bhutta ZA, Berkley JA, Bandsma RHJ, et al.Severe childhood malnutrition. Nat Rev Dis Primers 2017;3:17067.
  • 14. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96:1911-30.
  • 15. Short MW, Domagalski JE. Iron deficiency anemia: evaluation and management. Am Fam Physician 2013;87:98-104.
  • 16. Sezer RG, Bozaykut A, Akoglu HA, et al. The Efficacy of Oral Vitamin B12 Replacement for Nutritional Vitamin B12 Deficiency. J Pediatr Hematol Oncol 2018;40:69- 72.
  • 17. Zeeshan F, Bari A, Farhan S, et al. Correlation between maternal and childhood VitB12, folic acid and ferritin levels. Pak J Med Sci 2017;33:162-6.
  • 18. Pacheco-Cervera J, Codoñer-Franch P, Simó-Jordá R, et al. Reduced retinal nerve fibre layer thickness in children with severe obesity. Pediatr Obes 2015;10:448-53.
  • 19. Karti O, Nalbantoglu O, Abali S, et al. The assessment of peripapillary retinal nerve fiber layer and macular ganglion cell layer changes in obese children: a crosssectional study using optical coherence tomography. Int Ophthalmol 2017;37:1031-8.
  • 20. Ozen B, Oztürk H, Catli G, et al. An assessment of retinal nerve fiber layer thickness in non-diabetic obese children and adolescents. J Clin Res Pediatr Endocrinol 2018;10:13-8.
  • 21. Moschos MM, Gonidakis F, Varsou E, et al. Anatomical and functional impairment of the retina and optic nerve in patients with anorexia nervosa without vision loss. Br J Ophthalmol 2011;95:1128-33.
  • 22. Perkins JM, Kim R, Krishna A, McGovern M, Aguayo VM, Subramanian SV. Understanding the association between stunting and child development in low- and middle-income countries: Next steps for research and intervention. Soc Sci Med 2017;193:101-9.
  • 23. Kaur C, Foulds WS, Ling EA. Hypoxia-ischemia and retinal ganglion cell damage. Clin Ophthalmol 2008;2:879-89.
  • 24. Kergoat H, Hérard ME, Lemay M. RGC sensitivity to mild systemic hypoxia. Invest Ophthalmol Vis Sci 2006;47:5423-7.
  • 25. Connor JR, Menzies SL. Relationship of iron to oligodendrocytes and myelination. Glia 1996;17:83- 93.
  • 26. DeMaman AS, Homem JM, Lachat JJ. Early iron deficiency produces persistent damage to visual tracts in Wistar rats. Nutr Neurosci 2008;11:283-9.
  • 27. Youdim MB, Ben-Shachar D, Ashkenazi R, et al. Brain iron and dopamine receptor function. Adv Biochem Psychopharmacol 1983;37:309-21.
  • 28. Masson G, Mestre D, Blin O. Dopaminergic modulation of visual sensitivity in man. Fundam Clin Pharmacol 1993;7:449-63.
  • 29. Turkyilmaz K, Oner V, Ozkasap S, et al. Peripapillary retinal nerve fiber layer thickness in children with iron deficiency anemia. Eur J Ophthalmol 2013;23:217-22.
  • 30. Aksoy A, Aslan L, Aslankurt M, et al. Retinal fiber layer thickness in children with thalessemia major and iron deficiency anemia. Semin Ophthalmol 2014;29:22-6.
  • 31. Kalueff AV, Tuohimaa P. Neurosteroid hormone vitamin D and its utility in clinical nutrition. Curr Opin Clin Nutr Metab Care 2007;10:12-9.
  • 32. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.
  • 33. Schreiner DS, Jande SS, Lawson DE. Target cells of vitamin D in the vertebrate retina. Acta Anat (Basel). 1985;121:153-62.
  • 34. Uro M, Beauchet O, Cherif M, et al. Age-related vitamin D deficiency is associated with reduced macular ganglion cell complex: A cross-sectional highdefinition optical coherence tomography study. PLoS One 2015;10:0130879.
  • 35. Graffe A, Beauchet O, Fantino B, et al. Vitamin D and macular thickness in the elderly: an optical coherence tomography study. Invest Ophthalmol Vis Sci 2014; 55: 5298-303.
Annals of Medical Research-Cover
  • Yayın Aralığı: 12
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
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