Effects of diosmin-hesperidin and low pressure compression stocking combination in superficial venous insufficiency

Aim: The main aim of the study is to investigate the efficacy and patient tolerance of Daflon 1000mg/day and low-pressure compression stocking combination in the treatment of superficial venous insufficiency. Materials and Methods: This prospective study included 112 patients diagnosed with superficial venous insufficiency and reflux in saphenofemoral junction during March 2018 and 2019 at our center. All the patients received 1000 mg micronized purified flavonoid fractions containing 90% diosmin-10% hesperidin and low-pressure venous compression stockings (15-20 mmHg) throughout the study. Patients superficial, perforator, and deep venous systems were evaluated by Doppler US at the beginning and average of 5.3 ± 3.7 months after treatment. Results: A total of 99 (88.4%) patients out of 112 eligible patients completed the investigation. The mean age was 41±12.6, the female was 66 (58.9%), the mean follow-up was 5.3±3.7 months. Pre-treatment and post-treatment diameters of SFJ were 6.27±2.9 and 5.68±1.8 mm, respectively, this was statistically significant (P=0.033). All of the patients have SFJ reflux initially, after the treatment, patients with SFJ reflux were decreased to 44 (44.4%), this was also statistically significant (P

PDF

___

1. Matić M, Matić A, Gajinov Z, et al. Major risk factors for chronic venous disease development in women: is childbirth among them?. Women Health 2019; 59:1118-27.
2. Stapler SJ, Zurales K, Mazurek A, et al. A pilot study of venous duplex ultrasound parameters in healthy children. J Vasc Surg Venous Lymphat Disord. 2018; 6:347-50.
3. Akca B, Erdil N, Cengiz Colak M, et al. Treatment of chronic venous insufficiency with great saphenous vein endovenous radiofrequency ablation and miniphlebectomy in a single session. Turk J Vasc Surg 2017;26:85-90.
4. Eberhardt RT, Raffetto JD. Chronic venous insufficiency. Circulation. 2014;130:333-46.
5. Tsukanov YT, Tsukanov AY, Levdanskiy EG. Secondary Varicose Small Pelvic Veins and Their Treatment with Micronized Purified Flavonoid Fraction. Int J Angiol 2016; 25:121-7.
6. Ramelet AA. Clinical benefits of Daflon 500 mg in the most severe stages of chronic venous insufficiency. Angiology. 2001;52:49-56.
7. Nicolaides AN. From symptoms to leg edema: efficacy of Daflon 500 mg. Angiology. 2003;54:33-44.
8. Patel SK, Surowiec SM. Venous Insufficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020.
9. Russo R, Chandradhara D, De Tommasi N. Comparative Bioavailability of Two Diosmin Formulations after Oral Administration to Healthy Volunteers. Molecules. 2018;23:2174.
10. Takase S, Pascarella L, Lerond L, et al. Venous hypertension, inflammation and valve remodeling. Eur J Vasc Endovasc Surg 2004;28:484-93.
11. Bookwalter CA, VanBuren WM, Neisen MJ, et al. Imaging Appearance and Nonsurgical Management of Pelvic Venous Congestion Syndrome. Radiographics. 2019;39:596-608.
12. Pascarella L, Lulic D, Penn AH, et al. Mechanisms in experimental venous valve failure and their modification by Daflon 500 mg. Eur J Vasc Endovasc Surg 2008; 35:102-10.
13. Malkani RH, Karia R, Thadani S. A Study of Risk Factors of Chronic Venous Insufficiency and its Association with Features Suggestive of Preceding or Present Deep Venous Thrombosis. Indian J Dermatol 2019; 64:366-71.
14. Gracia S, Miserey G, Risse J, et al. Update of the SFMV (French society of vascular medicine) guidelines on the conditions and safety measures necessary for thermal ablation of the saphenous veins and proposals for unresolved issues. J Med Vasc 2020;45:130-46.
15. Beyaz MO, Bozkurt E, Onalan MA, et al. 'Evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus DNA.' Arch Med Sci 2019;15.
16. Slíva J. Diosmin - still an important modality in the treatment of venous insufficiency. Diosmin - stále důležitá modalita v léčbě žilní nedostatečnosti. Vnitr Lek 2019;65:524-6.